3,3',5-Triiodo-L-thyronine 3,3',5-三碘代-L-甲腺原氨酸/T3

CAS 6893-02-3 MFCD00002593

化学结构图

6893-02-3
SMILES: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O

化学属性

Mol. FormulaC15H12I3NO4
Mol. Weight651
Melting Point234-238
TSCANo

别名和识别编码

Chemical Name3,3',5-Triiodo-L-thyronine
Synonym 3,3′,5-三碘甲状腺氨酸 (T3) 3,5,3'-Triiodothyronine L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine L-Liothyronine L-Triiodothyronine L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- Liothyronin O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine T3 T3 (Hormone) T3 (amino acid) Thyronine, 3,3',5-triiodo-, L- Tresitope Triiodo-L-thyronine
CAS Number6893-02-3
PubChem Substance ID87576399
EC Number229-999-3
Beilstein Registry Number2710227
MDL NumberMFCD00002593
Reaxys-RN2710227
Merck Number5510
Chemical Name Translation3,3',5-三碘代-L-甲腺原氨酸/T3
Wiswesser Line NotationQVYZ1R CI EI DOR DQ CI
LabNetwork Molecule IDLN00193201
InChIInChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
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分类

  • {SNA} Cytokines, Growth Factors and Hormones, Hormones, Other Protein/Peptide Hormones, Peptides and Proteins, Peptides for Cell Biology, Thyroid Hormones, Triiodo-L-Thyronine (T3), 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, T, TP - TZ
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, T, TP - TZ
  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards,

相关文献及参考

  • [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.
  • Adams, A.C., et al., Thyroid Hormone Regulates Hepatic Expression Of Fibroblast Growth Factor 21 In A PPARalpha-dependent Manner. J. Bacteriol. 285 , 14075-82, (2010) 摘要
  • Adams, A.C., et al., Thyroid Hormone Regulates Hepatic Expression Of Fibroblast Growth Factor 21 In A PPARalpha-dependent Manner. J. Bacteriol. 285 , 14078-82, (2010) 摘要
  • Adams, A.C., et al., Thyroid Hormone Regulates Hepatic Expression Of Fibroblast Growth Factor 21 In A PPARalpha-dependent Manner. J. Thorac. Cardiovasc. Surg. 285 , 14078-82, (2010) 摘要
  • Beil. 14 ,IV,2373
  • Corp MSDS 1 (2), 3467:A / FT-NMR 1 (2), 1186:A / RegBook 1 (2), 1845:C / Sigma FT-IR 1 (1), 730:B / Structure Index 1 , 295:C:8
  • Merck 14 ,5510
  • Tiefenbach, J., et al., A Live Zebrafish

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSAY6750000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Light Sensitive 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPZHAW Roczniki Panstwowego Zakladu Higieny.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issue)/page/year: 32,197,1981

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 ug/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   11,529,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 ug/kg
SEX/DURATION            : female 16-22 day(s) after concepti

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 ug/kg
SEX/DURATION            : female 19-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   DPTHDL Developmental Pharmacology and Therapeutics.  (S. Karger Pub., Inc.,
   79 Fifth Ave., New York, NY 10003)  V.1-    1980-  Volume(issue)/page/year:
   12,162,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 300 ug/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Endocrine - changes in growth hormone
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    197

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TP - TZ - T
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Unnatural Amino Acid Derivatives 人工合成氨基酸
  5. Others - Unnatural Amino Acid Derivatives
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Unnatural Amino Acid Derivatives 人工合成氨基酸
  5. Others - Unnatural Amino Acid Derivatives
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Other Protein/Peptide Hormones - Hormones
  7. Triiodo-L-Thyronine (T3) - Other Protein/Peptide Hormones
  1. Thyroid Hormones - Peptides for Cell Biology
  2. Triiodo-L-Thyronine (T3) - Thyroid Hormones
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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