N-Benzyloxycarbonylglycine N-苄氧羰基-甘氨酸

CAS 1138-80-3 MFCD00002691

化学结构图

1138-80-3
SMILES: O=C(O)CNC(=O)OCc1ccccc1

化学属性

Mol. FormulaC10H11NO4
Mol. Weight209.20
Density1.289
Melting Point118-122°C
TSCAYes
Appearance 白色结晶或结晶性粉末；溶于甲醇和氯仿，不溶于冷水；mp为119-120℃。
Solubilitymethanol: 0.1 g/mL, clear
Boiling Point424°C at 760 mmHg
pH:A

别名和识别编码

Chemical NameN-Carbobenzoxyglycine
MDL NumberMFCD00002691
CAS Number1138-80-3
EC Number214-516-0
Beilstein Registry Number526877
Synonym Z-Glycine {LY} Z-Glycine {} {LY} Z-Glycine {} {} {LY} Z-Glycine {} {} {} {LY} Z-Glycine {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Z-Gly {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} N-carbobenzoxyglycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} N-benzyloxycarbonylglycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Cbz-Gly {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Z-Glycine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID14349
Reaxys-RN526877
Chemical Name TranslationN-苄氧羰基-甘氨酸
Wiswesser Line NotationQVN1R&1VQ
InChIKeyCJUMAFVKTCBCJK-UHFFFAOYSA-N
InChIInChI=1S/C10H11NO4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13)
LabNetwork Molecule IDLN00223153
Canonical SMILESO=C(O)CNC(OCC1=CC=CC=C1)=O
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分类

  • {Chemicalbook} 生物化学品: 生化试剂: 氨基酸及其衍生物
  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Glycine, Peptide Chemistry
  • {SNA} Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Glycine, Peptide Chemistry

产品应用

  • 用于生化试剂，地拉普利,氟地西泮,甲磺酸氯普唑仑和其它多肽合成。

相关文献及参考

  • Beilstein: 6,IV,2286

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P317
  • P337+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSMB9129000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C Store at RT. Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 70,60,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 70,60,1981

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • 毒性分级:中毒
  • 储运特性:库房低温通风干燥
  • 图谱信息:N-CBZ-L-丙氨酸(1138-80-3)核磁图( 1 HNMR) N-CBZ-L-丙氨酸(1138-80-3)质谱(MS) N-CBZ-L-丙氨酸(1138-80-3)红外图谱(IR1) N-CBZ-L-丙氨酸(1138-80-3)红外图谱(IR2)
  • 用途一:用作多肽试剂
  • 用途三:有机中间体。
  • 方法二:在冷却下，将氯甲酸苄酯和氢氧化钠溶液滴加到甘氨酸和氢氧化钠溶液的混合物中，同时激烈搅拌。反应毕，静置分出油层。水层用乙醚提取后冷却酸化至刚果红酸性，滤了沉淀，水洗、干燥，得产品苄氧羰基甘氨酸。产率86-91%。
  • 上游原料:甘氨酸 --> 氯甲酸苄酯 --> 直接红 28
  • 可燃性危险特性:热分解排出有毒氮氧化物烟雾
  • Alfa Aesar:N-苄氧羰基甘氨酸,98+% N-Benzyloxycarbonylglycine, 98+%(1138-80-3)
  • 急性毒性:叶鞘-小鼠 LD50: 380 毫克/公斤
  • MOL 文件:1138-80-3.mol
  • 用途四:用于生化试剂，地拉普利,氟地西泮,甲磺酸氯普唑仑和其它多肽合成。
  • N-CBZ-L-丙氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0575 N-苄氧羰基甘氨酸 N-Carbobenzoxyglycine 25G 279元 2014/06/02 C0575 N-苄氧羰基甘氨酸 N-Carbobenzoxyglycine 500G 2480元 2010/06/21 108355000 N-CBZ-L-丙氨酸 N-Carbobenzyloxyglycine 98.5% 500 GR 3923元
  • 类别:有毒物质
  • 方法一:以苄氧羰基叠氮和甘氨酸为原料，碱性条件下反应得粗品，再经乙醚提取、重结晶得纯品。
  • 用途二:用于多肽合成，用作氨基酸保护单体。
  • Acros Organics:N-苄氧羰酰甘氨酸 N-Carbobenzyloxyglycine, 98.50%(1138-80-3)
  • TCI Shanghai:N-苄氧羰基氨基乙酸 N-Carbobenzoxyglycine,>;98.0%(LC)(T)(1138-80-3)
  • MSDS 信息:Benzyloxycarbonyl glycine(1138-80-3).msds
  • 参考质量标准:含量不少于98%；mp118-120℃；乙醇溶解试验薄层层析试验合格。
  • 灭火剂:水, 干粉, 二氧化碳, 泡沫
  • 海关编码:29242995

系列性分类

  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Glycine - Amino Acid Derivatives
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Glycine - Amino Acid Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Modified Amino Acids - Amino Acids
  5. Cbz-amino Acids
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Protected & Labeled Amino Acids

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