• 原料直供
• 试剂商城
• 直接询价

分类

• {SA} Analytical Reagents, Analytical/Chromatography, Chemical Biology, Chemical Synthesis, Coupling, Derivatization Reagents, Derivatization Reagents HPLC, Others, Peptide Chemistry, Peptide Coupling, Synthetic Reagents, UV-VIS
• {SNA} Analytical Reagents,
• {SNA} Analytical Reagents, Analytical/Chromatography, Chemical Biology, Chemical Synthesis, Chromophores, Coupling, Derivatization Reagents, Derivatization Reagents HPLC, Glycan Labeling, Glycan Labeling and Analysis, Glycobiology, Others, Peptide Chemistry,
• {SNA} Chemical Biology,

产品应用

• 用ESI/MALDI -MS检测还原性碳水化合物的试剂。环保试剂

相关文献及参考

• [2]. Okamura, K., et al. Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. Neurol Res, 2013.
• [3]. Garcia CA, et al. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. Childs Nerv Syst. 2016 Dec 17. [Epub ahead of print]
• [4]. Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10.
• Merck: 14,6713
• Merck: 14,6713 Beilstein:24(2)9
• Undergoes lithiation with n-BuLi at the methylene group; see, e.g.: Synth. Commun., 20, 477 (1990).
• [1]. Yoshida, H., et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug R
• [1]. Yoshida, H., et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev, 2006. 12(1): p. 9-20.

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2012 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 36,27,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland
   Volume(issue)/page/year: 08FEB1979

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 31 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 300 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   17,196,1991

其他信息

• 下游产品:吡唑 --> 野燕枯硫酸二甲酯 --> 弱酸嫩黄G --> 3,5-二苯基吡唑 --> 酸性黄17 --> 媒介红 7 --> [2,4-二氢-4-[(2-羟基-5-硝基苯基)偶氮]-5-甲基-2-苯基-3H-吡唑-3-氧根合(2-)][1-[(2-羟基-4-硝基苯基)偶氮]-2-萘酚根合(2-)]钴酸(1-)钠 --> 中性枣红D-BN
• 用途二:用于合成安替匹林、氨基比林、安乃近等药物，制备酸性媒介枣红BN、永固黄G、皮革喷涂红G等染料
• 依达拉奉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30144826 1-苯基-3-甲基-5-吡唑酮 100g 51.5元 2011/04/16 M0687 3-甲基-1-苯基-5-吡唑啉酮 3-Methyl-1-phenyl-5-pyrazolone 25G 175元 2011/04/16 M0687 3-甲基-1-苯基-5-吡唑啉酮 3-Methyl-1-phenyl-5-pyrazolone 500G 611元
• TCI Shanghai:3-甲基-1-苯基-5-吡唑啉酮 3-Methyl-1-phenyl-5-pyrazolone,>;98.0%(T)(89-25-8)
• 上游原料:乙醇 --> 盐酸 --> 硫酸 --> 碳酸钠 --> 亚硝酸钠 --> 氢氧化铵 --> 氨 --> 甲醛 --> 硫酸二甲酯 --> 氨基苯 --> 甲酸 --> 焦亚硫酸钠 --> 二乙烯酮 --> 对甲苯胺 --> 甲烷 --> 乙酰氧基乙酸 --> 亚硫酸氢铵 --> 1,3-丁二酮胺 --> 亚硝酸铵
• 方法一:苯肼与乙酰乙酸乙酯反应而得。将苯肼和乙醇加热至50℃左右，开始加入乙酰乙酸乙酯，加完后回流4h。稍冷后放置过夜析出黄色结晶，过滤，将粗品用乙醇重结晶即为成品。另一种制法是由苯肼与丁酮酰胺反应。将苯肼与丁酮酰胺在50℃左右反应，反应结束后过滤、水洗、干燥而得成品。原料消耗定额：苯胺（98%）560kg/t、液氨1100kg/t、盐酸（30%）1280kg/t、醋酸1060kg/t、硫酸（93%）840kg/t、硫磺850kg/t、亚硝酸铵（95%）440kg/t。
• 图谱信息:依达拉奉(89-25-8)核磁图( 1 HNMR) 依达拉奉(89-25-8)核磁图( 13 CNMR) 依达拉奉(89-25-8)红外图谱(IR2) 依达拉奉(89-25-8)质谱(MS) 依达拉奉(89-25-8)红外图谱(IR1)
• 用途四:主要用于合成吡唑酮类解热镇痛药如安乃近、安替比林、氨基比林；也是吡唑酮类酸性染料如酸性媒介枣红BN、永固黄G以及彩色胶片染料、农药及及其他一些精细化学品的中间体。
• 溶于水，水中溶解度:3 g/l (20°C)。微溶于乙醇和苯，不溶于醚，溶于酸。
• Sigma Aldrich:89-25-8(sigmaaldrich)
• Acros Organics:3-甲基-1-苯基-吡唑啉-5-酮(别名:1,3,5-吡唑酮) 3-Methyl-1-phenyl-2-pyrazolin-5-one, 99%(89-25-8)
• 用途五:用ESI/MALDI -MS检测还原性碳水化合物的试剂。
• MSDS 信息:Edaravone(89-25-8).msds
• 用途三:用作测定钴、铜、铁、镍、银和维生素B12的试剂，也用于染料合成
• Alfa Aesar:3-甲基-1-苯基-2-吡唑啉-5-酮,98+% 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%(89-25-8)
• 海关编码:29331990
• 用途一:用于制备吡唑啉酮染料和药物等的中间体
• MOL 文件:89-25-8.mol