Sulfisoxazole, 99%, reference material 磺胺异恶唑

CAS 127-69-5 MFCD00003150

化学结构图

127-69-5
SMILES: Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C

化学属性

Mol. FormulaC11H13N3O3S
Mol. Weight267.30
Melting Point195°C
Solubility<0.1 G/100 ML AT 22.5 ºC
Appearance 磺胺二甲异唑(127-69-5)为白色或微黄色结晶性粉末，无臭，味苦。在甲醇中溶解，在乙醇中略溶，在水中几乎不溶，在稀盐酸或氢氧化钠溶液中溶解。熔点192～197℃，熔融时同时分解。
Density1.411

别名和识别编码

Chemical NameSulfisoxazole, 99%, reference material
CAS Number127-69-5
Alfabeta NameAMINODIMETHYLISOXAZOLYLBENZENESULFONAMIDE N4345()-------,
MDL NumberMFCD00003150
Synonym Sulfisoxazole {Chemicalbook} AKOS B020058 Ammonium Salt Sulfisoxazole Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazol Cosoxazole Diolamine, Sulfisoxazole Dorsulfan W {} {uni_hamburg} 5-Sulfanilamido-3,4-dimethylisoxazole {} {} {hazard_com} 5-(p-Aminobenzenesulphonamide)-3,4-dimethylisoxazole {} {} {} {uni_hamburg} 5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole {} {} {} {} { {} {} {} {} {Chemicalbook} 4-amino-n-(3,4-dimethyl-5-isoxazolyl)-benzenesulfonamid {} {} {} {} {} {uni_hamburg} 4-amino-N-(3,4-dimethyl-5-isoxazole)benzenesulfonamide {} {} {} {} {} {} {Chemicalbook} 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide {} {} {} {} {} {} {} {Chemicalbook} 4-AMINO-N-(3,4-DIMETHYL-5-ISOXAZOLYL)BENZENESULFONAMIDE {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {Chemicalbook} 3,4-dimethylisoxazole-5-sulfanilamide {} {} {} {} {} {} {} {} {} {Chemicalbook} 3,4-
PubChem Substance ID5344
Beilstein Registry Number6737262
EC Number204-858-9
Chemical Name Translation磺胺异恶唑
Merck Number8952
Wiswesser Line NotationT5NOJ CMSWR DZ& D1 E1
LabNetwork Molecule IDLN00166740
Reaxys-RN263871
InChIInChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
Canonical SMILESO=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O
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分类

  • {SNA} Analytical Standards, Antibiotics Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • {SNA} Bioactive Small Molecules,
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Endothelin - Receptor Antagonists, Endothelins, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Peptides and Proteins, Peptides for Cell Biology, Roche, S, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents,

相关文献及参考

  • [2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998
  • [3]. Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.
  • Merck: 14,8952
  • Short: EINECS
  • Short: IV/8A
  • [1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.
  • [1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.
  • [2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998
  • [3]. Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.

安全信息

Warnings IRRITANT
RTECSWO9100000
GHS Symbol
Precautionary statements
  • P362+P364
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P405 Store locked up. 上锁保管。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P403+P233
  • P337+P317
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P319
  • P305+P351+P338
  • P332+P317
  • P264+P265
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany2
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C 2-8℃ {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {TCI} 0-10°C 储存温度2-8℃ 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,1441,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
R

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,391,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,391,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,391,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 750 mg/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,59,1996

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 mg/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973

其他信息

  • 用途一:用于尿路感染流行性脊髓膜炎、菌痢、慢性胆囊炎、慢性前列腺炎、化脓性扁桃体炎等
  • MOL 文件:127-69-5.mol
  • Sigma Aldrich:127-69-5(sigmaaldrich)
  • 无臭，味苦。在甲醇中溶解，在乙醇中略溶，在水中几乎不溶，在稀盐酸或氢氧化钠溶液中溶解。熔融时同时分解。
  • MSDS 信息:Sulfafurazole(127-69-5).msds

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. S - Bioactive Small Molecules
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Endothelin Receptor  (内皮素受体)

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