N-Cbz-L-proline N-苄氧羰基-L-脯氨酸

CAS 1148-11-4 MFCD00003170

化学结构图

1148-11-4
SMILES: O=C(O)C1CCCN1C(=O)OCc1ccccc1

化学属性

Mol. FormulaC13
Mol. Weight249
Melting Point76.0 to 78.0 deg-C
TSCANo
Refractive index-40 ° (C=2, EtOH)
Density1.309

别名和识别编码

Chemical NameN-Cbz-L-proline
Synonym N-羰苄氧基-L-嘌呤 N-Benzyloxycarbonylproline 1-(Benzyloxycarbonyl)proline N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE N-Cbz-L-Proline L-CBZ-PROLINE N-苄氧羰基-L-脯氨酸, 98+% CBZ-L-脯氨酸 Z-PROLINE N-CARBOBENZOXY-L-PROLINE 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- N-CARBOBENZYLOXY-L-PROLINE N-Carbobenzoxy-L-proline (2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID Carbobenzoxy-S-proline CARBOBENZYLOXY-L-PROLINE L-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID Benzyloxycarbonyl-L-proline Carbobenzyloxy-L-proline Z-L-脯氨酸 Z-L-PRO-OH
MDL NumberMFCD00003170
PubChem Substance ID87565795
Beilstein Registry Number88579
CAS Number1148-11-4
EC Number214-557-4
Chemical Name TranslationN-苄氧羰基-L-脯氨酸
Reaxys-RN88579
LabNetwork Molecule IDLN00239651
InChIInChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
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分类

  • {SNA} Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Proline
  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Proline

产品应用

  • 用于生化试剂，缩宫素,增血压素的合成及其它多肽合成。

相关文献及参考

  • Beilstein: 22,V,1,84

安全信息

WGK Germany3
RTECSUY0745000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
GHS Symbol
Precautionary statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 ug/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 68,696,1979

其他信息

  • TCI Shanghai:N-苄氧羰基 -L-脯氨酸 N-Carbobenzoxy-L-proline,>;98.0%(T)(1148-11-4)
  • MSDS 信息:Z-Pro-OH(1148-11-4).msds
  • Alfa Aesar:N-苄氧羰基-L-脯氨酸,98+% N-Benzyloxycarbonyl-L-proline, 98+%(1148-11-4)
  • Sigma Aldrich:1148-11-4(sigmaaldrich)
  • 用途一:用于生化试剂，缩宫素,增血压素的合成及其它多肽合成。
  • MOL 文件:1148-11-4.mol
  • N-苄氧羰基-L-脯氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xp620057 N-苄氧羰基-L-脯氨酸 25g 84.4元 2011/04/16 C0713 N-苄氧羰基 -L-脯氨酸 N-Carbobenzoxy-L-proline 5G 206元 2011/04/16 C0713 N-苄氧羰基 -L-脯氨酸 N-Carbobenzoxy-L-proline 25G 663元
  • 图谱信息:N-苄氧羰基-L-脯氨酸(1148-11-4)红外图谱(IR2) N-苄氧羰基-L-脯氨酸(1148-11-4)质谱(MS) N-苄氧羰基-L-脯氨酸(1148-11-4)Raman光谱 N-苄氧羰基-L-脯氨酸(1148-11-4)红外图谱(IR1)
  • Acros Organics:N-羰苄氧基-L-脯氨酸 N-Carbobenzyloxy-L-proline, 99%(1148-11-4)
  • 外观性质:白色粉末状晶体。熔点：75～77℃
  • 比旋光度:-60 ° (c=2,AcOH)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Proline 脯氨酸
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Proline 脯氨酸
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Modified Amino Acids - Amino Acids
  5. Cbz-amino Acids
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Protected & Labeled Amino Acids

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