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• 试剂商城
• 直接询价

分类

• {SA} Alternative Energy, Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, CHROMASOLV Plus, Chromatography Reagents & Solvents, Electrolytes, HPLC & UHPLC Solvents (CHROMASOLV), HPLC Plus Grade Solvents (CHROMASOLV), HPLC/UHPLC Solvents (CHROMASOLV), Materials Science, NOWPak Products, Organic Solvents, Semi-Bulk Solvents,
• {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Environmental Standards, Heterocyclics,
• {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical
• {SNA}

产品应用

• 用作溶剂及萃取剂。
• NMP是一种极性的非质子传递溶剂，具有毒性小，沸点高，溶解能力出众，选择性强和稳定性好的优点。广泛用于芳烃萃取；乙炔、烯烃、二烯烃的纯化。也用于聚合物的溶剂及聚合反应的介质要。如聚酰胺、聚酰亚胺、聚苯硫醚等工程塑料及芳纶纤维。另外还用于绝缘材料、农药、颜料及清洁剂等方面。

相关文献及参考

• Short: III/35B
• Merck: 14,6117
• Nucleophilic displacement reactions with CN-: J. Chem. Soc., 954 (1962). Preparation of thiophenols from unactivated aryl chlorides and Na alkanethiolates: J. Org. Chem., 56, 3728 (1991). Reaction of thiophenol and potassium carbonate in uncatalyzed substitution reactions of chloroanilines and chloroanilides: J. Org. Chem., 56, 862 (1991). Synthesis of alkylaryl and alkylheteroaryl ethers, catalyzed by Cu(I): Tetrahedron, 48, 3633 (1992).
• Water-miscible, high-boiling dipolar aprotic solvent, compare N,N-Dimethyl­formamide, A13547 and Dimethyl­ sulfoxide, A13280, used in a wide variety of reactions, e.g.:
• Short: III/35D3
• Merck: 14,6117 Beilstein:21,237

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 18,922,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2472 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-1087-0695

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,408,1969

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 154 mmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,31,1988

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 ppm/6H
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   16,241,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 166 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BIRUAA Biologische Rundschau.  (VEB Gustav Fischer Verlag, Postfach 176,
   Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1963-  Volume(issue)/page/year:
   14,38,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 116 ppm/6H
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 18,271,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
S

其他信息

• MOL 文件:872-50-4.mol
• 微有胺的气味。能与水、醇、醚、酯、酮、卤代烃、芳烃和蓖麻油互溶。挥发度低，热稳定性
• 图谱信息:N-甲基吡咯烷酮(872-50-4)质谱(MS) N-甲基吡
• N-甲基吡咯烷酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30121590 1-甲基-2-吡咯烷酮;N-甲基-2-吡咯烷酮 500ml 150元
• 毒性分级:中毒
• Alfa Aesar:无水1-甲基-2-吡咯烷酮,99.5%,packagedunderArgoninrese
• 防护措施:对皮肤有轻度刺激作用，但未见吸收作用。由于蒸气压低，一次吸入的危险性很小。但慢性作用可致中枢神经系统机能障碍，引起呼吸器官、肾脏、血管系统的病变。小鼠吸入本品蒸气2小时，浓度为0.18～0.20mg/L，可对上呼吸道及眼睛产生轻度的刺激。小鼠灌胃LD50为5200 mg/kg，大鼠灌胃LD50为7900mg/kg。 工作场所最高容许浓度100mg/m3。 现场操作人员应戴口罩、防护眼镜及手套。
• color:≤20(APHA)
• 存储注意事项:氮气保护;湿度敏感
• 1-Methyl-2-pyrrolidinone is a pyrrolidinone compound solvent that has been documented to act a cosolvent and a complexing agent at the same time. The compound has been used in gel filtration of protected peptides, as well as utilized as a cryoprotective chemical for the freeze fracture technique.
• 上游原料:丙酮 --> 一甲胺 --> gamma-丁内酯 --> 丁酰胺
• 急性毒性:口服- 大鼠 LD50: 3914 毫克/ 公斤; 口服- 小鼠 LD50: 5130 毫克/ 公斤
• 类别:易燃液体
• 下游产品:2-(4-氯喹唑啉-7-氧基)乙酸乙酯 --> 三甲基氰硅烷 --> 6-三氟甲基吡啶-3-醛 --> 4-氨基丁酸 --> 1-苯并呋
• 微有胺的气味。能与水、醇、醚、酯、酮、卤代烃、芳烃和蓖麻油互溶。挥发度低，热稳定性、化学稳定性均佳，能随水蒸气挥发。有吸湿性。对光敏感。半数致死量（大鼠，经口）3.8ml/kg。
• Sigma Aldrich:872-50-4(sigmaaldrich)
• 用途:N-甲基吡咯烷酮(NMP)是一种极性的非质子传递溶剂。具有毒性小、沸点高、溶解力出众。选择性强和稳定性好的优点。广泛用于芳烃萃取、乙炔、烯烃、二烯烃的纯化，聚偏二氟乙烯的溶剂,锂离子电池的电极辅助材料,合成气脱硫、润滑油精制、润滑油抗冻剂、烯烃萃取剂、、难溶工程塑料聚合时的溶剂，农用除草剂，绝缘材料、集成电路制作，半导体行业精密仪器、线路板的洗净,PVC尾气回收，清洗剂、染料助剂、分散剂等。 也用于聚合物的溶剂及聚合反应的介质，如工程塑料及芳纶纤维。另外还可用在农药、医药和清洁剂等方面。
• Acros Organics:超干N-甲基吡咯烷酮 1-Methyl-2-pyrrolidinone, AcroSeal?, Extra Dry, 99.5%(872-50-4)
• 下游产品:2-(4-氯喹唑啉-7-氧基)乙酸乙酯 --> 三甲基氰硅烷 --> 6-三氟甲基吡啶-3-醛 --> 4-氨基丁酸 --> 1-苯并呋喃-5-甲腈 --> 3-氨基-6-氯吡啶-2-羧酸 --> 2-氯-6-三氟甲基烟酸 --> 4-三氟甲基烟酸 --> 5-三氟甲基吡啶-2-羧酸 --> (3,5-二甲氧基苯基)乙酸 --> 4-二甲基氨基丁酸盐酸盐 --> 6-(三氟甲基)吡啶-2-甲酸 --> N-(3'-丙胺基)-2-吡咯烷酮 --> 2-（二苯基羟亚膦基）乙基三乙氧基硅烷 --> 3-氨基-2-氰基吡啶 -->