3-(2-Furyl)acrylic acid 2-呋喃丙烯酸

CAS 539-47-9 MFCD00003257

化学结构图

539-47-9
SMILES:

化学属性

Mol. FormulaC7H6O3
Mol. Weight138.12
Boiling Point286°C at 760 mmHg
Melting Point140-143°C
TSCAYes
Flash Point286°C
Appearance 白色粉末或针状结晶。熔点141℃，沸点286℃，117℃（1.06kPa）。溶于乙醇、乙醚、苯和乙酸。1g该品可溶于15℃的500ml水。不溶于二硫化碳。112℃时可在高真空中升华，能随蒸气挥发。
Density1.28

别名和识别编码

Chemical Name3-(2-Furyl)acrylic acid
CAS Number539-47-9
Alfabeta NameFURYLPROPENOICACID E322(())-----
MDL NumberMFCD00003257
Synonym 3-(Furan-2-yl)acrylic acid {LY} 3-(Furan-2-yl)acrylic acid {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Furan-2-yl)acrylic acid {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID87569885
Beilstein Registry Number81048
EC Number208-718-8
Merck Number4297
Chemical Name Translation2-呋喃丙烯酸
Reaxys-RN81046
InChIKeyZCJLOOJRNPHKAV-ONEGZZNKSA-N
Wiswesser Line NotationT5OJ B1U1VQ
LabNetwork Molecule IDLN00227329
Canonical SMILESO=C(O)/C=C/C1=CC=CO1
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks

安全信息

Warnings IRRITANT
WGK Germany3
RTECSLT8560000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard Codes Xi
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 276 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 104,793,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   1,15,1978

其他信息

  • 上游原料:丙二酸 --> 丙烯醛
  • Alfa Aesar:3-(2-呋喃基)丙烯酸,99% 3-(2-Furyl)acrylic acid, 99%(539-47-9)
  • 2-呋喃丙烯酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0084 3-(2-呋喃基)丙烯酸 3-(2-Furyl)acrylic Acid 25G 701元 2014/06/02 F0084 3-(2-呋喃基)丙烯酸 3-(2-Furyl)acrylic Acid 10G 396元 2010/06/21 119841000 2-呋喃丙烯酸 Furylacrylic acid 99% 100 GR 1174元
  • 方法一:1.由糠醛与丙二酸反应而得。将糠醛、丙二酸加入吡啶中，加热回流2h，冷却，加水，在搅拌下加入浓氨水直至酸几乎全部溶解。将溶液过滤，滤饼用少量水洗涤，滤液和洗液合并，经盐酸酸化后，再于沸水浴上加热1.5-2h。将析出的沉淀滤出，用水洗涤，干燥而得成品，收率90-92%。2.由呋喃丙烯醛[623-30-3]氧化，酸析而得。将水、呋喃丙烯醛、氧化银与水的混合物加入反应锅，搅拌下在25℃左右通入氧气。10min后滴加35-50%的氢氧化钠溶液，在1h内加完1/2量，温度低于40℃，另一半氢氧化钠溶液在10min内加完后通入氧气10min，控制pH为11-12，冷却至40℃以下出料过滤。滤饼为氧化银，洗涤后套用。将洗、滤液用盐酸调节至pH为3，加热至90℃，使析出的呋喃丙烯酸结晶全部溶解，再冷却至30℃，析出结晶，甩滤，用冰水洗涤，烘干，得呋喃丙烯酸。3.由糠醛与乙酐缩合而得。在干燥的反应锅内，加入乙酐、糠醛及无水乙酸钠，在150℃搅拌回流7h，加入碎冰，过滤出粗品。将粗品混悬于热水中加热，加碱调节至pH为5.9-6。粗品全溶后加入活性炭在90℃脱色，过滤，滤液于50-60℃用盐酸调节至pH为3，析出结晶，过滤，水洗，干燥即得呋喃丙烯酸。另外，将糠醛与丙酮在氢氧化钠溶液中缩合，先制得亚糠基丙酮，再用漂白粉氧化也可得到该品，收率65%以上。
  • 下游产品:5-硝基呋喃-2-丙烯酸
  • 图谱信息:2-呋喃丙烯酸(539-47-9)Raman光谱 2-呋喃丙烯酸(539-47-9)质谱(MS) 2-呋喃丙烯酸(539-47-9)红外图谱(IR2) 2-呋喃丙烯酸(539-47-9)红外图谱(IR1) 2-呋喃丙烯酸(539-47-9)核磁图( 13 CNMR)
  • MSDS 信息:3-(2-Furyl)-2-propenoic acid(539-47-9).msds
  • Hazard Note:Irritant
  • Acros Organics:2-呋喃丙烯酸 Furylacrylic acid, 99%(539-47-9)
  • 海关编码:29321900
  • 用途一:呋喃丙烯酸是治疗血吸虫病药物呋喃丙胺的中间体。还用于制取庚酮二酸、庚二酸、乙烯呋喃及其酯类等。
  • Sigma Aldrich:539-47-9(sigmaaldrich)
  • TCI Shanghai:3-(2-呋喃基)丙烯酸 3-(2-Furyl)acrylic Acid,>;98.0%(GC)(T)(539-47-9)
  • MOL 文件:539-47-9.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  5. C4 to C7 - Furans

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