3-Methoxysalicylaldehyde 邻香草醛

CAS 148-53-8 MFCD00003322

化学结构图

148-53-8
SMILES: COc1cccc(C=O)c1O

化学属性

Mol. FormulaC8H8O3
Mol. Weight152.15
Boiling Point265.5°C at 760 mmHg
Melting Point40-42°C
Density1.231
TSCAYes
Solubility略溶于水
Stability对空气敏感
Flash Point113°C

别名和识别编码

Chemical Name3-Methoxysalicylaldehyde
CAS Number148-53-8
Alfabeta NameMETHOXYSALICYLALDEHYDE 3-
MDL NumberMFCD00003322
Synonym o-Vanillin {LY} o-Vanillin {} {LY} o-Vanillin {} {} {LY} o-Vanillin {} {} {} {LY} o-Vanillin {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Vanillin
PubChem Substance ID8991
EC Number205-715-3
Beilstein Registry Number471913
Reaxys-RN471913
Chemical Name Translation邻香草醛
Wiswesser Line NotationVHR BQ CO1
LabNetwork Molecule IDLN00173477
InChIInChI=1S/C8H8O3/c1-11-7-4-2-3-6(5-9)8(7)10/h2-5,10H,1H3
Canonical SMILESO=CC1=CC=CC(OC)=C1O
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分类

  • Aldehydes, Building Blocks, C8, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SNA} Aldehydes, Building Blocks, C8, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; aldehyde; alcohol; ether; 1fragment

产品应用

  • 用于制药及电镀等工业。

相关文献及参考

  • Tamai, K., et al.: Mutat. Res., 268, 231 (1992),
  • Davies, M., et al.: Biochem. J., 255, 513 (1988),
  • Beilstein:8,240
  • Short: EINECS
  • Short: IV/20B
  • Wang, M., et al.: J. Agric. Food Chem., 47, 3974 (1999),

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xn,Xi Xi
RTECSCU6530000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P333+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen Air Sensitive {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under ni
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 238,2576,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJANDP International Journal of Andrology.  (Scriptor Publisher ApS, 15
   Gasvaerksvej, DK-1656 Copenhagen V, Denmark)  V.1-    1978-
   Volume(issue)/page/year: 10,741,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 238,2576,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris

其他信息

  • 海关编码:29124900
  • 下游产品:3,4-二甲氧基-5-羟基苯甲醛 --> 2-乙酰基-7-甲氧基苯并呋喃 --> 7-甲氧基苯并呋喃-2-甲酸乙酯 --> 7-甲氧基苯并呋喃-2-甲酸 --> 5-溴-2-羟基-3-甲氧基苯甲醛 --> 2-羟基-3-甲氧基苄醇 --> 3-甲氧基儿茶酚
  • 图谱信息:邻香草醛(148-53-8)红外图谱(IR2) 邻香草醛(148-53-8)红外图谱(IR1) 邻香草醛(148-53-8)核磁图( 1 HNMR) 邻香草醛(148-53-8)核磁图( 13 CNMR) 邻香草醛(148-53-8)质谱(MS)
  • 用途一:用作医药中间体,是合成多种原料药和香料的重要起始原料
  • 敏感性:Air Sensitive
  • 用途二:用于制药及电镀等工业。
  • MSDS 信息:3-Methoxysalicylaldehyde(148-53-8).msds
  • 邻香草醛价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0262 邻香草醛 o-Vanillin 25G 218元 2014/06/02 H0262 邻香草醛 o-Vanillin 500G 1710元 2010/06/21 153075000 邻香草醛 o-Vanillin 99% 500 GR 2329元
  • MOL 文件:148-53-8.mol
  • Alfa Aesar:2-羟基-3-甲氧基苯甲醛,99% 2-Hydroxy-3-methoxybenzaldehyde, 99%(148-53-8)
  • F:10-23
  • 微溶于水。
  • Acros Organics:邻香草醛/2-羟基-3-甲氧基苯甲醛 o-Vanillin, 99%(148-53-8)
  • 上游原料:香兰素
  • TCI Shanghai:邻香草醛 o-Vanillin,>;99.0%(GC)(148-53-8)
  • Sigma Aldrich:148-53-8(sigmaaldrich)

系列性分类


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