4-(Dimethylamino)benzaldehyde 4-(二甲基氨基)苯甲醛

CAS 100-10-7 MFCD00003381

化学结构图

100-10-7
SMILES: CN(C)c1ccc(C=O)cc1

化学属性

Mol. FormulaC9H11NO
Mol. Weight149
Melting Point72-75
Refractive indexn20/D 1.417
Density1.10 g/mL at 20 °C
Flash Point164°(327°F)
Solubility水中溶解度:0.3 g/l (20°C),溶于乙酸、醇、醚和氯仿。
TSCAYes
Boiling Point176
Stability易吸潮,对光敏感

别名和识别编码

Chemical Name4-(Dimethylamino)benzaldehyde
Synonym 4-(DIMETHYLAMINO)B 4-(Dimethylamino)benzaldehyde 4-(Dimethylamino)benzenecarbonal 4-Formyl-N,N-dimethylaniline 4-N,N-二甲氨基苯甲醛 p-D p-Dimethylaminobenzaldehyd p-N,N-dimethylaminobenzaldehyde Benzaldehyde, 4-(dimethylamino)- EHRICH'S REAGENT EHRLICH'S REAGENT ERLICH'S REAGENT Ehrlich's Reagent Ehrlich’s reagent Kovac 吲哚试剂 N,N-DIMETHYL-P-AMINO BENZALDEHYDE N,N-二甲基-4-氨基苯甲醛 p-Dimethylaminobenzaldehyde DMAB Ehrlich 试剂 p-Formyldimethylaniline {} {} {Chemi {} {} {Chemicalbook} {} {} {uni_ha 对(N,N-二甲基)苯甲醛 对二甲氨基苯甲醛 溶液 对二甲氨基苯甲醛 溶液 按照 Kovac 方法的吲哚试剂
Beilstein Registry Number606802
PubChem Substance ID87567986
CAS Number100-10-7
EC Number202-819-0
MDL NumberMFCD00003381
Reaxys-RN606802
Merck Number3230
Chemical Name Translation4-(二甲基氨基)苯甲醛
Wiswesser Line NotationVHR DN1&1
LabNetwork Molecule IDLN00199569
InChIInChI=1S/C9H11NO/c1-10(2)9-5-3-8(7-11)4-6-9/h3-7H,1-2H3
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分类

  • {SNA} Aldehydes, Building Blocks, C9, Carbonyl Compounds, Cell Biology, Chemical Synthesis, D, Hematology and Histology, Organic Building Blocks, Stains & Dyes, A to Z, Stains and Dyes
  • {SNA} Aldehydes,
  • {SNA} Aldehydes, Biochemical Reagents for Identification, Building Blocks, C9, Carbonyl Compounds, Chemical Synthesis, Identification Tests & Reagents, Microbiology, Organic Building Blocks
  • {SNA} Aldehydes, Building Blocks, C9, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SNA} Aldeh

产品应用

  • 测定吲哚、粪臭素、尿蓝母、色氨酸、白蛋白、过氧化氢、胂凡钠明、邻氨基苯甲酸、安替比林麦角碱等,还用以区别血清发疹和腥红热。制造染料。

相关文献及参考

  • Reagent for conversion of Grignard reagents to the corresponding aldehydes via the carbinol which is cleaved by an aryldiazonium salt to give the aldehyde and the 4-(dimethylamino)azo compound: J. Org. Chem., 25, 1691 (1960); 27, 279 (1962); Org. Synth. Coll., 5, 46 (1973).
  • Color reagent for pyrroles and amines: J. Am. Chem. Soc., 86, 2441 (1964); F. Feigl, Spot Tests, vol. 2, Elsevier, Amsterdam (1954), p. 198.
  • Short: III/20a
  • Short: III/35B
  • Merck:14,3230
  • Reagent for determination of amino acids and peptides.

安全信息

WGK Germany1
RTECSCU5775000
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Symbol
Hazard Codes C Xn C,Xn,Xi F,Xi Xi
Hazard statements
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H332 Harmful if inhaled 吸入有害
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H318 Causes serious eye damage 严重伤害眼睛
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger Warning
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37 Wear suitable gloves 戴适当手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
Risk Statements
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
  • R10 Flammable 易燃
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R22 Harmful if swallowed 吞咽有害
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R11 Highly flammable 非常易燃
  • R36 Irritating to eyes 刺激眼睛
  • R20 Harmful by inhalation 吸入有害
  • R37 Irritating to respiratory system 刺激呼吸道
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R52/53
Storage condition 充氩保存 易吸潮,密封避光保存。 充氩储存 Air & Light Sensitive Air Sensitive 2-8°C
UN Number UN 2920 8/PG 2
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 90,260,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533441

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINEL* Hine Laboratories Reports.  (San Francisco, CA)
   Volume(issue)/page/year: AF33(657)-11756,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533441

其他信息

  • 水中溶解度:0.3 g/l (20°C),溶于乙酸、醇、醚和氯仿。
  • Alfa Aesar:4-二甲氨基苯甲醛,ACS 4-Dimethylaminobenzaldehyde, ACS(100-10-7)
  • 下游产品:4-二甲氨基苄胺 --> 4-二甲氨基苯甲酸
  • MSDS 信息:对二甲基氨基苯醛(100-10-7).msds
  • 敏感性:Air Sensitive
  • 用途一:用作染料中间体
  • Sigma Aldrich:100-10-7(sigmaaldrich)
  • 用途四:测定吲哚、粪臭素、尿蓝母、色氨酸、白蛋白、过氧化氢、胂凡钠明、邻氨基苯甲酸、安替比林麦角碱等,还用以区别血清发疹和腥红热。制造染料。
  • MOL 文件:100-10-7.mol
  • 用途二:用作测定尿胆素、吲哚、生物碱等的试剂及色谱分析试剂
  • 海关编码:29223900
  • Acros Organics:二甲氨基苯甲醛,检测氨基酸和多肽用TLC高效喷显剂 Dimethylaminobenzaldehyde, ozone friendly ready to use spray for TLC(100-10-7)
  • 对二甲胺基苯甲醛价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 10008714 4-(二甲氨基)苯甲醛;4-二甲氨基苯甲醛;对二甲替氨基苯甲醛;N,N-二甲基-4-氨基苯甲醛;对二甲胺基苯甲醛 25g 21元 2011/04/16 D1495 4-二甲氨基苯甲醛 4-Dimethylaminobenzaldehyde 25G 229元 2011/04/16 D1495 4-二甲氨基苯甲醛 4-Dimethylaminobenzaldehyde 500G 1600元
  • TCI Shanghai:4-二甲基氨基苯甲醛 4-Dimethylaminobenzaldehyde,>;99.0%(T)(100-10-7)
  • 图谱信息:对二甲胺基苯甲醛(100-10-7)核磁图( 13 CNMR) 对二甲胺基苯甲醛(100-10-7)质谱(MS) 对二甲胺基苯甲醛(100-10-7)红外图谱(IR3) 对二甲胺基苯甲醛(100-10-7)红外图谱(IR2) 对二甲胺基苯甲醛(100-10-7)核磁图( 1 HNMR) 对二甲胺基苯甲醛(100-10-7)红外图谱(IR1)
  • F:8
  • 方法一:以N,N-二甲基苯胺为原料,可采用两种方法生产。(1)以乌洛托品反应生成亚甲基-N,N-二甲氨基苄胺,转位生成N,N-二甲基亚苄甲胺,然后水解得产品。(2)与二甲基甲酰胺在三氯氧磷存在下反应。另外,还有一种实验室制备方法是,以N,N-二甲基苯胺、亚硝酸钠、甲醛为原料制备。
  • 用途三:染料中间体和分析试剂。该品用于测定吲哚、粪臭素、尿蓝母、色氨酸和麦角碱等,还用以区别血清发疹和猩红热。在染料方面,可用来合成压热敏染料。也用于生产阳离子艳红G(C.I.Basic Red 52)。
  • 外观性质:灰白色的结晶粉末。
  • 上游原料:乙酸 --> 三氯氧磷 --> 氨 --> 甲醛 --> 乌洛托品 --> 苄胺 --> N-甲基苯胺 --> 二甲代苯胺 (异构体混合物)

系列性分类


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