• 原料直供
• 试剂商城
• 直接询价

分类

• {Chemicalbook} 生物化学品: 生化试剂: 激素
• {SNA} Bioactive Small Molecules, CI-CY, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones, 细胞生物学
• {SNA} Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
• Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
• {SNA} Analytical Standards, Analytic

产品应用

• Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461

相关文献及参考

• [2]. McCue RE, et, al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation. 1978 Jun;3(2):159-76.
• [3]. Seleem D, et, al. In Vivo Antifungal Activity of Monolaurin against Candida albicans Biofilms. Biol Pharm Bull. 2018;41(8):1299-1302.
• [4]. Rusu VM, et, al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115(5):1370-4.
• Beil. 8 ,IV,3481
• Colburn, W. et al.: J. Clin. Pharmacol., 20, 428 (1980); Bailey, J.M. et al.: Atherosclerosis, 17, 515 (1973);
• FT-IR 2 (3), 4251:B / FT-NMR 1 (3), 602:B / RegBook 1 (2), 2873:F / Sigma FT-IR 1 (1), 1224:B / Structure Index 1 , 460:C:5
• Merck 14 ,2539
• [1]. Hirano T, et, al. Cortisone counteracts
• [1]. Hirano T, et, al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1(12):2109-15.

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Vascular - tumors
   Musculoskeletal - tumors
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 33,1640,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,19,1977

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,19,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 30 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   DEVPED Development (Cambridge, UK). (Biochemical society Book Depot, POB 32,
   Commerce Way, Colchester, Essex CO2 8HP, UK) V.99-   1987-
   Volume(issue)/page/year: 100,611,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 1-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 28,464,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 56 mg/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,27,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocul

其他信息

• 用途二:泼尼松醋酸酯的中间体。本身为抗炎剂。用于治疗肾上腺皮质低功能症、类风湿性关节炎、风湿病、红斑狼疮等病。
• 醋酸可的松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0389 醋酸可的松 Cortisone Acetate 1G 421元 2014/06/02 C0389 醋酸可的松 Cortisone Acetate 5G 1240元 2010/06/16 C0389 乙酸可的松 Cortisone Acetate 25G 3410元
• TCI Shanghai:乙酸可的松 Cortisone Acetate,>;99.0%(LC)(50-04-4)
• 醋酸可的松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 C0389 醋酸可的松 Cortisone Acetate 1G 332元 2011/04/16 C0389 醋酸可的松 Cortisone Acetate 5G 971元 2010/06/16 C0389 乙酸可的松 Cortisone Acetate 25G 3410元
• 用途一:生化研究，肾上腺皮质激素类药物，具有抗炎、抗过敏等作用。
• 方法一:以醋酸孕甾双烯醇酮为原料，依次经过氧化氢氧化、沃氏氧化、黑根菌生物氧化、铬酐氧化得11-酮基-16，17α环氧黄体酮，经氢溴酸开环，氢化脱溴得可的松，后者与碘反应，再与熔融醋酸钾作用得粗品，最后重结晶而得。
• Sigma Aldrich:50-04-4(sigmaaldrich)
• 上游原料:过氧化氢 --> 镍 --> 三氧化铬 --> 醋酸妊娠双烯醇酮酯 --> 乙酸钾 --> 16,17-环氧黄体酮 --> 铬酸 --> 皂素 --> 可的松 --> 16-妊娠双烯醇酮
• 方法二:用妊娠双烯醇酮经环氧化、沃氏氧化、霉菌氧化、铬酸氧化、溴化氢开环，雷尼镍催化脱溴、碘化并乙酰氧基置换制得。
• MOL 文件:50-04-4.mol
• 下游产品:氢化可的松 --> 泼尼松 --> 醋酸泼尼松
• 图谱信息:醋酸可的松(50-04-4)红外图谱(IR2) 醋酸可的松(50-04-4)质谱(MS) 醋酸可的松(50-04-4)红外图谱(IR1) 醋酸可的松(50-04-4)核磁图( 13 CNMR)
• 参考质量标准:含量达97.0%-103.0%，mp≥238C，比旋光度[α] 20 D +208°- +217°，检测干燥失重及灼烧残渣等杂质含量。