Prednisolone 氢化波尼松

CAS 50-24-8 MFCD00003649

化学结构图

50-24-8
SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO

化学属性

Mol. FormulaC21H28O5
Mol. Weight360.44
Melting Point240 °C
Refractive index100 ° (C=1, Dioxane)
Density1.0
Stability对光敏感
Boiling Point412.46 °C at 760 mmHg

别名和识别编码

Chemical NamePrednisolone
CAS Number50-24-8
Synonym Prednisolone {LY} Prednisolone {} {LY} Prednisolone {} {} {LY} Prednisolone {} {} {} {LY} Prednisolone {} {} {} {} {LY} Prednisolone {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Prednisolone {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00003649
PubChem Substance ID5755
Beilstein Registry Number1354103
EC Number200-021-7
Chemical Name Translation氢化波尼松
Merck Number7721
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 CQ E1 FV1Q FQ
LabNetwork Molecule IDLN00839316
InChIInChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Canonical SMILESC[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C1
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分类

  • {SA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, P, Steroid Hormones
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Corticosteroid, Cytokines, Growth Factors and Hormones, Fluorination Ready Pharma-Developed Compounds, Hormones, Johnson & Johnson, PI-PZ, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Analy
  • {SNA} Additional Standards, All Doping Standards (A-Z), Analytical Standards, Application Areas and Market Segments, Biomarkers and Metabolomics Standards,

产品应用

  • 校准仪器和装置;评价方法;工作标准;质量保证/质量控制

相关文献及参考

  • [2]. Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565(1-2):89-102.
  • Ali, S.L., et al.: Anal. Profiles Drug Subs. Excip., 21, 415 (1992),
  • Beil. 8 ,IV,3467
  • Corp MSDS 1 (2), 2914:C / FT-IR 2 (3), 4233:D / FT-NMR 1 (3), 585:B / RegBook 1 (2), 2863:J / Sax 6 , 2285 / Sigma FT-IR 1 (1), 1291:A / Structure Index 1 , 458:C:7
  • Jusko, W.J., et al.: Ther. Drug Monit., 2, 169 (1980),
  • Merck 14 ,7721
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/5b Title: Structure Data of Organic Crystals: C 14 ... C 120 Author: Sc

安全信息

RTECSTU4152000
GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Danger
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADTEAS Advances in Teratology.  (New York, NY)  V.1-5, 1966-72.
   Discontinued.  Volume(issue)/page/year: 3,181,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 9 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - toxic psychosis
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 18

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1680 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,111,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 16,63,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mou

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1600 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 4560 ug/L
REFERENCE :
   EJCODS European Journal of Cancer and Clinical Oncology.  (Pergamon Press,
   c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)  V.17(7)-
   25, 1981-89.  For publisher information, see EJCAEL Volume(issue)/page/year:
   18,533,1982

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   24,219,1975

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 30 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   18,847,1969

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1450 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1200 ug/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Spe

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 23 mg/kg
SEX/DURATION            : female 1-33 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,117,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 56 mg/kg
SEX/DURATION            : female 1-40 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,117,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 14-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   CGANE7 Congenital Anomalies.  (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi,
   Osakasayama, Osaka-Fu 589 Japan)  V.27-    1987-  Volume

Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P302+P352
  • P304+P312
  • P304+P340
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 肾上腺皮质激素:泼尼松龙又称氢化泼尼松,氯泼尼松,强的松龙,去氢氢化可的松,百力特,醋酸泼尼松龙,醋酸酯为白色或几乎白色结晶性粉末,无臭,味苦。几乎不溶于水,微溶于乙醇或氯仿。属肾上腺糖皮质激素及促皮质激素用药,为中效糖皮质激素。其疗效与泼尼松相当,其抗炎作用更强,水盐代谢作用很弱。 本品为羟基化合物(羟基在11位上),局部应用疗效较好,如皮肤病和眼病,因其在局部直接有效,也适用于肝功能不全患者。口服吸收快而完全,1小时达血药浓度峰值,血浆蛋白结合率为90%~95%,半衰期约200分钟。能进入胎儿循环,出现于乳汁的药量为0.07%~0.23%。经肝内代谢,主要从肾脏排泄,其中原形药占20%以上。 泼尼松龙主要用于过敏性和炎症性疾病。由于本品潴钠作用较弱,故一般不用肾上腺皮质功能减退的替代治疗。肾上腺皮质机能亢进、高血压病、动脉粥样硬化、心力衰竭、糖尿病、精神病、癫痫、手术后病人以及胃、十二指肠溃疡、肠道疾病或慢性营养不良的病人应避免使用。一般感染不要用本类药物。急性感染中毒时,必须与足量的有效抗菌药物配合应用,对重度结核病应合并使用足量的抗结核药,并根据病情,及时减量和停用。
  • MSDS 信息:1,4-Pregnadiene-11b,17a,21-triol-3,20-dione(50-24-8).msds
  • 上游原料:氢化可的松
  • 下游产品:泼尼卡酯 --> 11Β,17Α-二羟基-21-(甲磺酰氧基)孕甾-1,4-二烯-3,20-二酮
  • Sigma Aldrich:50-24-8(sigmaaldrich)
  • 不良反应与副作用:大量或长期应用本品时,可引起肥胖、多毛、痤疮、血糖升高、高血压、眼内压升高、钠和水潴留、水肿、血钾降低、精神兴奋、胃及十二指肠溃疡甚至出血穿孔、骨质疏松、脱钙、病理性骨折、伤口愈合不良等。 局部注射或应用时,有时可引起关节损伤、局部坏死、皮肤萎缩等。
  • 图谱信息:泼尼松龙(50-24-8)质谱(MS) 泼尼松龙(50-24-8)红外图谱(IR1) 泼尼松龙(50-24-8)核磁图( 1 HNMR) 泼尼松龙(50-24-8)红外图谱(IR2)
  • 用途一:适用于类风湿关节炎、风湿热、红斑狼疮、皮肌炎、多发性骨髓瘤等,还可制取氢化泼尼松醋酸酯。
  • 方法一:可用氢化可的松经消除(生物节杆菌脱氢)制得该品。
  • MOL 文件:50-24-8.mol

系列性分类


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