• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Analytical Standards, EP Standards, EP Standards L - M, Pharmacopeia Metrological Institutes Standards,
• {SA} Bile acids and Derivatives, Biochemicals and Reagents,
• {SNA} Analytical Standards,
• {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards
• {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 13ring; 14ring; 17ring; carboxylic acid; alcohol; chiral; 1fragment
• {SNA} Bile acids and Derivatives, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, L, Lipids, Sterol Lipids
• Steroids
• Pharmaceuticals
• Intermediates & Fine Chemicals
• {SNA} Bile acids and Derivatives, Sterol Lipids, 生化试剂, 脂类

产品应用

• A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.

相关文献及参考

• [2]. Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.
• [3]. Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2(10): p. 761-82.
• [4]. Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707.
• Brindle, J., et al.: Nat. Med., 12, 1439
• Merck: 14,5545 Beilstein:10(3)687
• Short: EINECS
• Short: III/35E
• [1]. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21
• [1]. Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21-6.

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 5 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 8 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 83300 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,447,1984

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   52,311,1985

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 75 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   24,181,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8800 mg/kg
SEX/DURATION            : female 0-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 43,355,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16 gm/kg
SEX/DURATION            : female 0-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 43,355,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30160 ug/kg
SEX/DURATION            : female 12-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 42,215,1990

TYPE OF TEST            : TDLo - Low

其他信息

• Sigma Aldrich:434-13-9(sigmaaldrich)
• TCI Shanghai:石胆酸 Lithocholic Acid,>;97.0%(GC)(T)(434-13-9)
• 石胆酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 69015080 石胆酸;3-羟基胆基酸;石胆甾酸;胆石酸 10g 107.8元 2011/08/23 SL625001 石胆酸;3-羟基胆基酸;石胆甾酸;胆石酸 10g 605元 2011/04/16 L0089 石胆酸 Lithocholic Acid 5G 495元
• Acros Organics:石胆酸 Lithocholic acid, 98%(434-13-9)
• 外观性质:胆汁酸之一。不是由胆甾醇在肝中直接生物合成的，而是由鹅脱氧胆酸在肠内通过细菌代谢产生的物质。在肠内生成的这种物质大部分与粪便一起排出，极少一部分被吸收，在肝中发生结合反应，以牛磺石胆酸（taurolithocholic acid）或甘氨石胆酸（glyclithocholic acid）形态出现于胆汁中。比其它胆汁酸毒性强，大量饲实验动物能引起肝胆道系统的种种障害。熔点: 183-188 °C
• MOL 文件:434-13-9.mol
• 图谱信息:石胆酸(434-13-9)质谱(MS) 石胆酸(434-13-9)红外图谱(IR2) 石胆酸(434-13-9)红外图谱(IR1) 石胆酸(434-13-9)核磁图( 13 CNMR)
• 胆汁酸之一。不是由胆甾醇在肝中直接生物合成的，而是由鹅脱氧胆酸在肠内通过细菌代谢产生的物质。在肠内生成的这种物质大部分与粪便一起排出，极少一部分被吸收，在肝中发生结合反应，以牛磺石胆酸（taurolithocholic acid）或甘氨石胆酸（glyclithocholic acid）形态出现于胆汁中。比其它胆汁酸毒性强，大量饲实验动物能引起肝胆道系统的种种障害。