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分类

• {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Drugs, Additional Standards, Analytical Standards, Chromatography, Clofibrate Metabolites, Pharmaceutical Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
• {SA} Analytical Standards, Analytical/Chromatography, Building Blocks, C10, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
• Analytical Standards, Analytical/Chromatography, Building Blocks,
• {SNA} Building Blocks, C10, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building

产品应用

• A hypolipidemic compound

相关文献及参考

• [2]. Salgado R, et, al. Biodegradation of clofibric acid and identification of its metabolites. J Hazard Mater. 2012 Nov 30;241-242:182-9.
• [3]. Kawashima Y, et, al. Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid. Biochim Biophys Acta. 1982 Dec 13;713(3):622-8.
• FT-IR 2 (2), 2614:D / FT-IR 1 (2), 165:A / FT-NMR 1 (2), 1025:C / IR-Spectra (3), 945:E / NMR-Reference 2 (2), 160:B / RegBook 1 (2), 1761:H / Sax 6 , 798 / Sigma FT-IR 1 (2), 388:B / Structure Index 1 , 281:C:5
• Merck 14 ,2378
• [1]. Forman BM, et, al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl
• [1]. Forman BM, et, al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7.

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human
DOSE/DURATION           : 260 mg/kg/91D
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   ATHSBL Atherosclerosis (Shannon, Ireland).  (Elsevier Scientific Pub.
   Ireland Ltd., POB 85, Limerick, Ireland)  V.11-    1970-
   Volume(issue)/page/year: 36,159,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 727 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSPMA6 Travaux de la Societe de Pharmacie de Montpellier. (Soc. de Pharmacie
   de Montpellier, Faculte de Pharmacie de Montpellier, Ave. Ch.-Flahault,
   34060 Montpellier, France)  V.1-    1942- Volume(issue)/page/year:
   34,121,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 683 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 3

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 683 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 33,150,1970

TYPE OF TEST

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2100 mg/kg/1W (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,1557,1991

其他信息

• MOL 文件:882-09-7.mol
• Alfa Aesar:2-(4-氯苯氧基)异丁酸,98% 2-(4-Chlorophenoxy)isobutyric acid, 98%(882-09-7)
• TCI Shanghai:2-(4-氯苯氧基)异丁酸 2-(4-Chlorophenoxy)isobutyric Acid,>;97.0%(T)(882-09-7)
• Clofibric acid 是PPARα激动剂，是一种降血脂剂。
• Acros Organics:2-(4-氯苯氧基)-2-甲基丙酸 2-(4-Chlorophenoxy)-2-methylpropionic acid, 99%(882-09-7)
• Sigma Aldrich:882-09-7(sigmaaldrich)
• 下游产品:氯贝特
• Hazard Note:Irritant
• 图谱信息:4-氯苯氧异丁酸(882-09-7)红外图谱(IR2) 4-氯苯氧异丁酸(882-09-7)质谱(MS) 4-氯苯氧异丁酸(882-09-7)红外图谱(IR1)
• 用途一:用于医药安妥明中间体
• 4-氯苯氧异丁酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0940 2-(4-氯苯氧基)异丁酸 2-(4-Chlorophenoxy)isobutyric Acid 500G 1980元 2014/06/02 C0940 2-(4-氯苯氧基)异丁酸 2-(4-Chlorophenoxy)isobutyric Acid 25G 273元 2010/06/21 189092500 4-氯苯氧异丁酸 2-(4-Chlorophenoxy)-2-methylpropionic acid 99% 250 GR 1346元
• 方法一:由对氯苯酚经缩合而得。将对氯苯酚和丙酮加入反应锅，搅拌下加入氢氧化钠，在20℃左右滴加氯仿，反应温度控制在25-30℃，此时反应激烈，当反应缓和后加热回流3h。蒸馏回收丙酮，加水，加热至70℃使溶解，加入盐酸至pH为2-3，冷却析出结晶。冷至10℃以下，甩滤，用水洗涤至无油状物，干燥，得成品。收率约为80%。
• 用途二:制药中间体，用于安妥明、安妥明铝盐、安妥明丙二酸酯等。