D-Serine D-丝氨酸

CAS 312-84-5 MFCD00004269

化学结构图

312-84-5
SMILES: N[C@H](CO)C(=O)O

化学属性

Mol. FormulaC3H7NO3
Mol. Weight105.09
Melting Point220°C
TSCAYes
Density1.415
Solubility346 G/L (20 ºC)
Boiling Point394.8°C at 760 mmHg

别名和识别编码

Chemical NameD-Serine
CAS Number312-84-5
Alfabeta NameSERINE D-
MDL NumberMFCD00004269
Synonym D-Serine {LY} D-Serine {} {LY} D-Serine {} {} {LY} D-Serine {} {} {} {LY} D-Serine {} {} {} {} {LY} D-Serine {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Serine {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID71077
Beilstein Registry Number1721403
EC Number206-229-4
Reaxys-RN1721403
Merck Number14,8460
Chemical Name TranslationD-丝氨酸
LabNetwork Molecule IDLN00008527
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
Canonical SMILESN[C@H](CO)C(O)=O
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分类

  • Amino Acid Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Biology, Chemical Synthesis, GABA and Glycine Receptor Modulators, Glycinergics, Ion Channels, Ligand-Gated
  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis,

产品应用

  • A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.

相关文献及参考

  • [2]. MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25.
  • [3]. Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.
  • [4]. Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.
  • Brugger, et al., Modulation of NMDA receptor by D-serine in the cortex and the spinal cordin vitro. Eur. J. Pharmacol. 191 , 29, (1990) 摘要
  • Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);
  • Merck 14 ,8460
  • Merck: 14,8460
  • Merck: 14,8460 Beilstein:4,505
  • [1]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric
  • [1]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.

安全信息

Warnings IRRITANT
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSVT8200000
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • 水中溶解度: 346 G/L (20°C)，不溶于乙醇、乙醚和苯；不溶于有机溶剂。
  • MOL 文件:312-84-5.mol
  • 所属类别一:生物化学品: 生化试剂: 氨基酸及其衍生物
  • TCI Shanghai:D-丝氨酸 D-Serine,>;98.5%(T)(312-84-5)
  • 方法一:在碱性条件下以DL-丝氨酸和氯乙酰氯为原料反应，减压蒸干后用乙酸乙酯萃取，经活性炭处理、酰化酶I拆分后得产品。
  • Sigma Aldrich:312-84-5(sigmaaldrich)
  • 图谱信息:D-丝氨酸(312-84-5)红外图谱(IR2) D-丝氨酸(312-84-5)Raman光谱 D-丝氨酸(312-84-5)红外图谱(IR1)
  • Acros Organics:D-丝氨酸 D-Serine, 98%(312-84-5)
  • 所属类别二:生物化学品: 多肽及蛋白质类: 促皮质素及其衍生物
  • D-丝氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xp620058 D-丝氨酸;D-蚕丝氨基酸;D-2-氨基-3-羟基丙酸;D-β-羟基丙氨酸 5g 52.5元 2011/04/16 S0033 D-丝氨酸 D-Serine 25G 1200元 2011/04/16 S0033 D-丝氨酸 D-Serine 5G 437元
  • 上游原料:氯乙酰氯 --> 2-甲基-2-丙烯酸-2-丁氧基乙酯 --> 丝氨酸 --> 酰化氨基酸水解酶
  • 用途二:对颞颥动脉炎、多发性风湿病等炎症性患者有效。
  • 用途一:用作医药中间体，生化试剂
  • 用途三:用于生化研究，组织培养基的制备，医药上用作氨基酸类营养药。
  • Alfa Aesar:丝氨酸,99% D-Serine, 99%(312-84-5)
  • MSDS 信息:D-Serine(312-84-5).msds
  • 比旋光度:-14.75 ° (c=10 2 N HCl)
  • 参考质量标准:比旋光度[α] 20 D -13.5°--15.5°(0.5-2.0 mg/ml，HCl)，纸层析合格。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Serine - Amino Acid Derivatives
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Glycinergics - Neurotransmitters
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Ligand-Gated Ion Channels - Ion Channels
  6. GABA and Glycine Receptor Modulators - Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Modified Amino Acids - Amino Acids
  5. Cbz-amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Ion Channels
  5. Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Neurotransmission
  6. Neurotransmitters
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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