Propiolic Acidd 丙炔酸

CAS 471-25-0 MFCD00004360

化学结构图

471-25-0
SMILES: C#CC(=O)O

化学属性

Mol. FormulaC3H2O2
Mol. Weight70
Density1.138
Refractive index1.4290 to 1.4350
Flash Point-
TSCAYes
Boiling Point-
Melting Point16-18
SolubilityMISCIBLE
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NamePropiolic Acidd
Synonym (Z)-2-Propynoic Acid 2-PROPYNOIC ACID Acetylencarbonsäure Acetylenecarboxylic acid Acetylenecarboxylic acid~Propargylic acid~Propynoic acid Carboxyacetylene HCequivCCOOH Propargylic acid Propiolic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number-
CAS Number471-25-0
EC Number207-437-8
Beilstein Registry Number2,477
Merck Number7821
PubChem Substance ID10110
Reaxys-RN878176
Chemical Name Translation丙炔酸
LabNetwork Molecule IDLN00221630
InChIInChI=1S/C3H2O2/c1-2-3(4)5/h1H,(H,4,5)
Canonical SMILES-
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信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks
  • {uni_hamburg} no charge; carboxylic acid; 1fragment

产品应用

  • 用于有机合成。

相关文献及参考

  • Short: II/19b
  • Short: II/14a
  • Merck: 14,7821 Beilstein:2,477
  • Merck: 14,7821
  • Alkylation of the dilithio-derivative leads to higher 2-alkynoic acids. Reaction with epoxides, partial reduction (Lindlar) of the triple bond and cyclization has been used in the synthesis of unsaturated lactones: Tetrahedron Lett., 2615 (1974); J. Org. Chem., 40, 1610 (1975).
  • Short: II/22a

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P350
  • P302+P352
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSUD9300000
Packing GroupII
UN Number 2920
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H310 Fatal in contact with skin 皮肤接触致命
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes T
Storage condition +4 +4°C 2-8°C 4 4°C 4℃ 储存温度2-8℃
Hazard Class8/3
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty

Restrict -

其他信息

  • 海关编码:29161980
  • 具有炔烃和羧酸的双重特性,能进行还原、加成、氧化、酯化和环化以及生成盐和酰氯等反应。溶于水。
  • 丙炔酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0497 丙炔酸 Propiolic Acid 5G 214元 2014/06/02 P0497 丙炔酸 Propiolic Acid 25G 604元 2010/06/21 131500100 丙炔酸 Propiolic acid 98% 10 ML 662元
  • 灭火剂:水、二氧化碳、砂土
  • MSDS 信息:丙炔酸(471-25-0).msds
  • TCI Shanghai:丙炔酸 Propiolic Acid,>;97.0%(GC)(T)(471-25-0)
  • Acros Organics:2-丙炔酸 Propiolic acid, 98%(471-25-0)
  • 外观性质:无色粘稠液体。
  • 用途二:用于有机合成。可用于制取丙酸、均苯三甲酸、卤代丙烯酸、二卤代丙烯酸、二乙炔二羧酸、丙炔酸乙酯、吡唑啉酮、二溴巴豆酸,乙氧基巴豆酸等。丙炔酸与硫酸、甲醇加热回流可制得丙炔酸甲酯(C4H4O2,[922-67-8]),是抗病毒药物碘苷的原料。
  • F:3-8
  • 下游产品:3-氨基异恶唑 --> 3Β,17Β-二羟基孕甾-5-烯-21-羧酸-Γ-内酯 --> 3Β,17Β-二羟基孕甾-5-烯-21-羧酸
  • 急性毒性:口服-大鼠 LC50: 100 毫克/公斤; 口服-小鼠 LD50: 100 毫克/公斤
  • 类别:腐蚀物品
  • Alfa Aesar:丙炔酸,98+% Propiolic acid, 98+%(471-25-0)
  • 方法一:1.由丙炔醇氧化而得。将丙炔醇加入丙酮中搅拌,于20℃滴加铬酐的硫酸溶液,加毕,室温搅拌14h,即生成丙炔酸。2.以乙炔钠和CO2在3.55-7.09MPa和90℃以下温度反应,即得。
  • MOL 文件:471-25-0.mol
  • 图谱信息:丙炔酸(471-25-0)红外图谱(IR1) 丙炔酸(471-25-0)质谱(MS)
  • 可燃性危险特性:遇热可燃
  • 上游原料:发烟硫酸 --> 三氧化铬 --> 2-丙炔-1-醇 --> 乙炔钠
  • 毒性分级:高毒
  • Sigma Aldrich:471-25-0(sigmaaldrich)
  • 用途一:用作有机合成中间体,可与甲醇在硫酸催化下生成丙炔酸甲酯,是生产抗病毒药物碘苷的原料
  • 储运特性:库房通风低温干燥; 与氧化剂、碱分开存放

系列性分类