3-Hydroxy-4-Methoxycinnamic Acid,Trans 3-羟基-4-甲氧基肉桂酸(反式)

CAS 537-73-5 MFCD00004391

化学结构图

537-73-5
SMILES: COc1ccc(C=CC(=O)O)cc1O

化学属性

Mol. FormulaC10H10O4
Mol. Weight194
Melting Point230
Density1.316
TSCANo

别名和识别编码

Chemical Name3-Hydroxy-4-Methoxycinnamic Acid,Trans
CAS Number537-73-5
Synonym 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)- 3-HYDROXY-4-METHOXYCINNAMIC ACID 3-HYDROXY-4-METHOXYCINNAMIC ACID, 97%, P REDOMINANTLY TRANS 3-Hydroxy-4-methoxycinnamic acid 3-hydroxy-4-methoxycinnamic acid 3-羟基-4-甲氧基肉桂酸，主要为反式 3-羟基-4-甲氧基肉桂酸/异阿魏酸 3-羟基-4-甲氧基肉桂酸; 3-羟基-4-甲氧基肉桂酸;3-羟基-4-甲氧基苯乙烯酸;3-羟-4-甲氧桂皮酸 4-Methoxy-3-hydroxycinnamic acid AKOS BBS-00006960 Cinnamic acid, 3-hydroxy-4-methoxy- Hesperetic acid ISOFERULIC ACID Isoferulic Isoferulic Acid RARECHEM BK HW 0093 isoferulic acid trans-3-Hydroxy-4-methoxycinnamic acid 橘皮酸
MDL NumberMFCD00004391
PubChem Substance ID736186
EC Number208-676-0
Beilstein Registry Number2212760
Reaxys-RN2212760
Chemical Name Translation3-羟基-4-甲氧基肉桂酸(反式)
LabNetwork Molecule IDLN02139342
InChIInChI=1S/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
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分类

  • Alphabetical, Analytical Standards, Analytical/Chromatography, Chromatography, Cimicifuga, I - M, Lavandula, Life Sciences Standards, Natural Compounds, Phenylpropanes, Phytopharma Standards, Salvia, Scrophularia, Standards by Plant Genus, Substance Classification, Valeriana
  • {SNA} Building Blocks, C10, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks

产品应用

  • 3-Hydroxy-4-methoxycinnamic acid was used in the synthesis of tranilast and various tranilast analogs (cinnamoyl anthranilates) by genetically engineered Saccharomyces cerevisiae yeast strain.

相关文献及参考

  • [2]. Sakai S, et al. Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice. Mediators Inflamm. 2001 Apr;10(2):93-6.
  • Beilstein:10,437
  • Liu, I.-M., et al.: J. Pharmacol. Exp. Ther., 307, 1196 (2003),
  • [1]. Liu IM, et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204.
  • [1]. Liu IM, et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204.
  • [2]. Sakai S, et al. Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice. Mediators Inflamm. 2001 Apr;10(2):93-6.

安全信息

WGK Germany2
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSUD3365400
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 储存温度2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7900 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 95,539,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 95,539,1975

其他信息

  • Sigma Aldrich:537-73-5(sigmaaldrich)
  • MSDS 信息:3-Hydroxy-4-methoxycinnamic acid(537-73-5).msds
  • TCI Shanghai:3-羟基-4-甲氧基肉桂酸 3-Hydroxy-4-methoxycinnamic Acid,>;98.0%(LC)(T)(537-73-5)
  • 海关编码:29189090
  • 植物来源 升麻根茎
  • Alfa Aesar:3-羟基-4-甲氧基苯乙烯酸,predominantlytrans,98+% 3-Hydroxy-4-methoxycinnamic acid, predominantly trans, 98+%(537-73-5)
  • 3-羟基-4-甲氧基肉桂酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0524 3-羟基-4-甲氧基肉桂酸 3-Hydroxy-4-methoxycinnamic Acid 5G 1620元 2014/06/02 H0524 3-羟基-4-甲氧基肉桂酸 3-Hydroxy-4-methoxycinnamic Acid 1G 474元 2010/06/21 146890050 3-羟基-4-甲氧基肉桂酸 3-Hydroxy-4-methoxycinnamic acid 97%, predominantly trans 5 GR 1579元
  • 图谱信息:3-羟基-4-甲氧基肉桂酸(537-73-5)核磁图( 1 HNMR) 3-羟基-4-甲氧基肉桂酸(537-73-5)红外图谱(IR2) 3-羟基-4-甲氧基肉桂酸(537-73-5)质谱(MS) 3-羟基-4-甲氧基肉桂酸(537-73-5)红外图谱(IR1) 3-羟基-4-甲氧基肉桂酸(537-73-5)核磁图( 13 CNMR)
  • Acros Organics:3-羟基-4-甲氧基肉桂酸/异阿魏酸 3-Hydroxy-4-methoxycinnamic acid, predominantly trans, 97%(537-73-5)
  • Hazard Note:Irritant
  • MOL 文件:537-73-5.mol

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C10 - Carboxylic Acids
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Alphabetical - Phytopharma Standards
  7. I - M - Alphabetical
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids
  6. C1 to C5
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)