Mandelonitrile 扁桃腈

CAS 532-28-5 MFCD00004487

化学结构图

532-28-5
SMILES: N#CC(O)c1ccccc1

化学属性

Mol. FormulaC8H7NO
Mol. Weight133
Refractive index1.5300 to 1.5370
Boiling Point102°C/14mmHg(lit.)
Density1.117
Flash Point97°C(lit.)
TSCAYes
Melting Point-10°
Solubility不溶于水,易溶于醇、醚、氯仿。

别名和识别编码

Chemical NameMandelonitrile
Synonym α-Cyanobenzyl alcohol Mandelsäurenitril Benzaldehyde, cyanohydrin Benzaldehydkyanhydrin alpha-Hydroxyphenylacetonitrile ALPHA-氰基苄醇 Hydroxyphenylacetonitrile MANDELONITRILE Nitril kyseliny mandlove α-氰基苄醇 Benzeneacetonitrile, α-hydroxy-, (±)- alpha-hydroxy-benzeneacetonitril (±)-Mandelonitrile Benzaldehyde cyanohydrin DL-Mandelsäurenitril Phenylglycolonitrile Phenylglykolsäurenitril (±)-2-hydroxy-2-phenyl-acetonitrile α-Hydroxybenzeneacetonitrile Benzaldehydecaanohydrin 苯乙醇腈, TECH A-Hydroxyphenylacetonitril 苦杏仁腈 Mandelic acid nitrile MANDELIC ACID NITRILE 马来腈 Amygdalonitrile BENZALDEHYDE CYANOHYDRIN nitrilkyselinymandlove ALPHA-HYDROXYPHENYLACETONITRILE alpha-Hydroxybenzeneacetonitrile benzaldehyde cyanohydrin Acetonitrile, hydroxyphenyl- 苯乙醇腈 2-Hydroxy-2-phenylacetonitrile α-Hydroxyphenylacetonitrile -Hydroxybenzeneacetonitrile Benzaldehydcyanhydrin DL-ALPHA-HYDROXYPHENYLACETONITRILE hydroxyphenyl-acetonitril 苯甲氰醇 dl-Mandelonitrile α-氰基苄醇 杏仁腈 苯甲氰醇 Glycolonitrile, phenyl- Benzeneacetonitrile, α-hydroxy- 杏仁腈 ALPHA-CYANOBENZYL ALCOHOL -Cyanobenzylalcohol DL-MANDELIC ACID NITRILE 扁桃腈
MDL NumberMFCD00004487
CAS Number532-28-5
PubChem Substance ID87572597
EC Number208-532-7
Beilstein Registry Number10,193
Merck Number5719
Reaxys-RN2207122
Chemical Name Translation扁桃腈
Wiswesser Line NotationQYR&CN
LabNetwork Molecule IDLN00195845
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; alcohol; racemate; 1fragment
  • {SNA} Building Blocks, C8 to C9, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks

相关文献及参考

  • Short: EINECS
  • Short: IV/16

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311+H331
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H318 Causes serious eye damage 严重伤害眼睛
  • H331 Toxic if inhaled 吸入中毒
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSOO8400000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Packing GroupIII
UN Number 3276 UN 3276 6.1/PG 3 UN3276
Risk Statements
  • R50/53
  • R25 Toxic if swallowed 吞咽有毒
  • R38 Irritating to skin 刺激皮肤
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S22 Do not breathe dust 不要吸入粉尘;
Storage condition Moisture Sensitive
Hazard Codes T
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 12,447,1904

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 600 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 5,161,1899

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 5,161,1899

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Resea

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 225 nmol/plate
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   198,625,1977

Restrict 危险品

其他信息

  • 用途一:有机中间体。
  • 毒性分级:剧毒
  • F:21
  • 灭火剂:干粉, 砂土, 泡沫, 二氧化碳
  • MSDS 信息:苯乙醇腈(532-28-5).msds
  • 急性毒性:皮下-小鼠 LDL0 1.16 毫克/公斤
  • 可燃性危险特性:可燃; 受热放出有毒氰化氢和氮氧化物气体
  • 类别:有毒物品
  • 方法一:由苯甲醛与氰化钠加成而得。将氰化钠溶于水,搅拌冷却,在-5~5℃滴加苯甲醛,加完后再加入盐酸,温度保持在10℃左右,静置。分取油层,水洗,得成品。
  • 外观性质:黄色粘稠液体,具有特殊臭味。
  • 图谱信息:扁桃腈(532-28-5)红外图谱(IR2) 扁桃腈(532-28-5)核磁图( 1 HNMR) 扁桃腈(532-28-5)红外图谱(IR1) 扁桃腈(532-28-5)核磁图( 13 CNMR) 扁桃腈(532-28-5)质谱(MS)
  • 储运特性:库房通风低温干燥; 与氧化剂, 酸类, 食品分开储运
  • Acros Organics:扁桃腈 Mandelonitrile, tech.(532-28-5)
  • 上游原料:氰化钠
  • TCI Shanghai:扁桃腈 Mandelonitrile,>;97.0%(GC)(532-28-5)
  • Sigma Aldrich:532-28-5(sigmaaldrich)
  • 刺激数据:眼睛-兔子 0.25 毫克/24小时 重度
  • Alfa Aesar:苯乙醇腈,tech.80% Mandelonitrile, tech. 80%(532-28-5)
  • 敏感性:Moisture Sensitive
  • MOL 文件:532-28-5.mol
  • 扁桃腈价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0566 扁桃腈 Mandelonitrile 25G 357元 2014/06/02 M0566 扁桃腈 Mandelonitrile 500G 3310元 2010/06/21 152090250 扁桃腈 Mandelonitrile , tech. 25 ML 265元

系列性分类


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