10,11-Dihydro-5H-Dibenz[b,f]Azepine 亚氨基二苄

CAS 494-19-9 MFCD00005070

化学结构图

494-19-9
SMILES: c1ccc2c(c1)CCc1ccccc1N2

化学属性

Mol. FormulaC14H13N
Mol. Weight195.26
Density1.422
Melting Point105-108 °C
TSCAYes
Appearance 浅黄色结晶。熔点109-110℃。
Boiling Point327.7 °C at 760 mmHg

别名和识别编码

Chemical Name10,11-Dihydro-5H-Dibenz[b,f]Azepine
CAS Number494-19-9
Alfabeta NameDIHYDRODIBENZOAZEPINE HBF10115[]---,,
MDL NumberMFCD00005070
Synonym Iminodibenzyl {LY} Iminodibenzyl {} {LY} Iminodibenzyl {} {} {LY} Iminodibenzyl {} {} {} {LY} Iminodibenzyl {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Iminodibenzyl {} {} {} {} {} {} {} {} {} {} {}
EC Number207-787-1
Beilstein Registry Number152732
PubChem Substance ID10308
Chemical Name Translation亚氨基二苄
Reaxys-RN152732
Wiswesser Line NotationT C676 BM&T&J
LabNetwork Molecule IDLN00159363
InChIInChI=1S/C14H13N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-8,15H,9-10H2
Canonical SMILESC12=CC=CC=C1CCC3=CC=CC=C3N2
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分类

  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards I - K
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Homopiperidines
  • Heterocycles
  • Enzyme substrates
  • {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards I - K, 分析/色谱
  • Aromatics
  • Metabolites & Impurities

产品应用

  • 10,11-Dihydro-5H-dibenzo[b,f]azepine is a metabolite of the tricyclic antidepressant, Imipramine (I465980). 10,11-Dihydro-5H-dibenzo[b,f]azepine can be used as a chromogenic probe for the quantificati

相关文献及参考

  • Crammer, J.L. et al.: Psychopharmacologia, 18, 26 (1970); Christiansen, J. et al.: J. Pharm. Pharmacol., 25, 604 (1973); Hackett, A.M. et al.: Xenobiotica, 14, 491 (1984); Nagaraja, P. et al.: Anal. B

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R36 Irritating to eyes 刺激眼睛
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P305+P351+P338
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P333+P313
  • P337+P313
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSHN8950000
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H320 Causes eye irritation 刺激眼睛
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes Xi 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01352

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 图谱信息:亚氨基二苄(494-19-9)核磁图( 1 HNMR) 亚氨基二苄(494-19-9)红外图谱(IR2) 亚氨基二苄(494-19-9)核磁图( 13 CNMR) 亚氨基二苄(494-19-9)质谱(MS) 亚氨基二苄(494-19-9)红外图谱(IR1)
  • TCI Shanghai:亚氨基二苄 10,11-Dihydro-5H-dibenzo[b,f]azepine,>;95.0%(T)(494-19-9)
  • MSDS 信息:10,11-Dihydro-5H-dibenz[b,f]azepine(494-19-9).msds
  • 海关编码:29339930
  • 上游原料:2-硝基甲苯
  • Sigma Aldrich:494-19-9(sigmaaldrich)
  • Acros Organics:亚胺联苄 Iminodibenzyl, 97%(494-19-9)
  • 用途一:用作抗癫痫药卡马西平中间体
  • 方法一:由邻硝基甲苯经缩合、还原、环合而得。
  • 亚氨基二苄价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D0269 10,11-二氢-5H-二苯并[b,f]氮杂卓 10,11-Dihydro-5H-dibenzo[b,f]azepine 25G 292元 2010/06/21 122071000 亚氨基二苄 Iminodibenzyl 97% 100 GR 692元 2010/06/21 122070250 亚氨基二苄 Iminodibenzyl 97% 25 GR 212元
  • MOL 文件:494-19-9.mol
  • 用途二:该品为医药中间体，用于生产镇痛抗痉挛药酰胺咪嗪。也用于合成润滑油，高温抗氧剂。
  • Alfa Aesar:二苯基亚胺,97% Iminodibenzyl, 97%(494-19-9)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  5. N-Containing - Others
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Azepine 阿西平
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Triazines

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