12-Crown-4 12-冠醚-4

CAS 294-93-9 MFCD00005103

化学结构图

294-93-9
SMILES: C1COCCOCCOCCO1

化学属性

Mol. FormulaC8H16O4
Mol. Weight176.21
Density1.089
Refractive indexn20/D 1.463(lit.)
Flash Point>109°(228°F)
TSCAYes
Boiling Point61-70 °C at 0.5 mmHg
Melting Point16 °C
SolubilityMISCIBLE
Stability对空气敏感;对光敏感

别名和识别编码

Chemical Name12-Crown-4
MDL NumberMFCD00005103
Synonym 1,4,7,10-Tetraoxacyclododecane {LY} 1,4,7,10-Tetraoxacyclododecane {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4,7,10-Tetraoxacyclododecane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number206-036-5
CAS Number294-93-9
Beilstein Registry Number1363064
PubChem Substance ID9269
Reaxys-RN1363064
Chemical Name Translation12-冠醚-4
Wiswesser Line NotationT-12-O DO GO JOTJ
LabNetwork Molecule IDLN01363684
InChIInChI=1S/C8H16O4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h1-8H2
Canonical SMILESO1CCOCCOCCOCC1
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分类

  • {uni_hamburg} no charge; oxygen heterocycle; alicycle; large ring; 12ring; ether; 1fragment
  • {SNA} Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Synthetic Reagents

产品应用

  • An aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent

相关文献及参考

  • Short: EINECS
  • Short: III/35E
  • Crown ether suited to complexing lithium ions.

安全信息

RTECSXF0550000
UN Number 2810 UN 2810 UN2810
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R26 Very toxic by inhalation 吸入极毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S4 Keep away from living quarters 远离生活区；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Storage condition Air Sensitive Light & Air Sensitive & Hygroscopic 密封保存。 对空气敏感，密封保存。
GHS Symbol
WGK Germany3
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Packing GroupIII
Hazard Codes 6.1 T+ T+,Xn Xn
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3150 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,263,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1290 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 8,451,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2830 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 1,339,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4530 uL/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0536186

TYPE OF TEST

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 ppb/7H
SEX/DURATION            : male 15 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,342,1974

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 ppm/7H
SEX/DURATION            : male 15 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,342,1974

其他信息

  • Alfa Aesar:12-冠-4,98% 12-Crown-4, 98%(294-93-9)
  • MSDS 信息:1,4,7,10-Tetraoxacyclododecane(294-93-9).msds
  • Sigma Aldrich:294-93-9(sigmaaldrich)
  • Acros Organics:12-冠醚-4 12-Crown-4, 97%(294-93-9)
  • 图谱信息:12-冠醚-4(294-93-9)质谱(MS) 12-冠醚-4(294-93-9)Raman光谱 12-冠醚-4(294-93-9)核磁图( 13 CNMR) 12-冠醚-4(294-93-9)核磁图( 1 HNMR) 12-冠醚-4(294-93-9)红外图谱(IR1)
  • 敏感性:Air Sensitive
  • MOL 文件:294-93-9.mol
  • 海关编码:29329995
  • TCI Shanghai:12-冠4-醚 12-Crown 4-Ether,>;95.0%(GC)(294-93-9)
  • F:3-9-23
  • 12-Crown-4 is a Phase transfer catalyst, complexing-agent for lithium. Aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.
  • 12-冠醚-4价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0858 12-冠4-醚 12-Crown 4-Ether 1ML 293元 2014/06/02 C0858 12-冠4-醚 12-Crown 4-Ether 5ML 865元 2010/06/21 187020050 12-冠醚-4 12-Crown-4 97% 5 GR 942元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Chelation/Complexation Compounds - Synthetic Reagents
  4. Crown Ethers 环状冠醚
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Chelation/Complexation Compounds
  4. Calixarenes 杯芳烃
  1. Materials Science 材料科学
  2. Macrocycles for Host-Guest Chemistry