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分类

• {SA} Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Anti
• {
• {SNA} Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), Ion Channels, Ionophores, Mechanism of Action, Monovalent Ion Channels, Peptides, V, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
• {SNA} Antibacterial, Antibiotic Ready Made Solutions,
• {SNA} Antibiotics A to Z, Antibiotics

产品应用

• A potassium ionophore shown to induce cell death;Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes.
• Valinomycin is an apoptosis inducer. It is used as a tool in membrane research

相关文献及参考

• Merck: 14,9910
• Furlong, I.J., et al., Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification. Cell Death Differ. 5 , 214-221, (1998)
• Short: III/5b
• Merck 14 ,9910
• Short: EINECS
• Ivanov, et al.: Biochem. Biophys. Res. Commun., 34, 803 (1969),
• Merck: 14,9910 Beilstein: 27,IV,9728
• Duax, et al.: Science, 176, 911 (1972),

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 8,451,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 1,325,19

TYPE OF TEST            : LD50 - Lethal dose, 50 pe

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 390 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 390 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

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其他信息

• 是一种由12个氨基酸组成的环形小肽，它是一种脂溶性的抗生素。将缬氨霉素插入脂质体后，通过环的疏水面与脂双层相连, 极性的内部能精确地固定K+。它在一侧结合K+,然后向内侧移动通过脂双层, 在另一侧将K+释放到细胞内。缬氨酶素可使K+的扩散速率提高100，000倍，但是它不能有效地提高Na+的扩散速度。 结构 缬氨霉素的化学结构含有重复三次的D-缬氨酸、L-乳酸、L-缬氨酸和D-羟基异戊酸盐序列的环状肽。 水中溶解度:1 g/L (20°C)，溶于石油醚、醚、苯、氯仿、冰乙酸、丁酸和丙酮。
• Valinomycin is a cyclodepsipeptide and potassium ionophore that has been shown to induce cell death. The compound has been shown to have antibabesial activity and reported to promote hemolysis in HK erythrocytes, and decrease the intracellular ATP concentration. CHO cell studies demonstrate that cells exposed to Valinomycin display caspase-3 activation, phosphatidylserine membrane translocation, and mitochondrial membrane depolarization. Can be used as a biosensor to detect potassium efflux as well.