Epibromhydrin 环氧溴丙烷

CAS 3132-64-7 MFCD00005130

化学结构图

3132-64-7
SMILES: BrCC1CO1

化学属性

Mol. FormulaC3H5BrO
Mol. Weight136.98
Refractive index1.4790 to 1.4840
Boiling Point
Density1.601
Melting PointN/A
Stability对光敏感
Flash Point-
Solubility不溶于水，溶于热乙醇、乙醚、苯、氯仿。

别名和识别编码

Chemical NameEpibromhydrin
CAS Number3132-64-7
Synonym ######## (±)-(Brommethyl)oxiran (±)-(Bromomethyl)oxirane (±)-3-Bromo-1,2-epoxypropane (±)-Epibromohydrin 1,2-Epoxy-3-bromopropane 1,2-環氧-3-溴丙烷 1-bromo-2,3-epoxy-propan 1-bromo-2,3-epoxy-propane 2-(Bromomethyl)oxirane 3-BROMOPROPYLENE OXIDE 3-Bromopropylene oxide 3-bromo-1,2-epoxy-propan 3-溴-1,2-环氧丙烷 BROMOMETHYLOXIRANE Epibromhydrin Epibromohydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID18430
EC Number221-525-3
Beilstein Registry Number79786
MDL Number-
Reaxys-RN79786
Chemical Name Translation环氧溴丙烷
Wiswesser Line NotationT3OTJ B1E
LabNetwork Molecule IDLN00239728
InChIInChI=1S/C3H5BrO/c4-1-3-2-5-3/h3H,1-2H2
Canonical SMILES-
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分类

  • Building Blocks, Chemical Synthesis, Epoxides, Organic Building Blocks, Oxygen Compounds
  • {uni_hamburg} no charge; oxygen heterocycle; alicycle; 3ring; ether; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Epoxides, Organic Building Blocks, Oxygen Compounds

产品应用

  • Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies.

相关文献及参考

  • Short: II/25C
  • Weng, W., et al.: J. Clin. Oncol., 21, 3940 (2003); Shields, R., et al.: J. Biol. Chem., 277, 26733 (2002),
  • Sicard, H., et al.: J. Immunol. 175, 5471 (2005),
  • Beilstein:17,9
  • Short: II/14a

安全信息

GHS Symbol
WGK Germany2
Hazard Codes 6.1 Xn
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTX4115000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312
  • P301+P316
  • P301+P317
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning {} {} {} {} {} {} {} {} {TCI}
UN Number 2558
Storage condition 2-8°C 4 4°C 4°C, Inert atmosphere 密封避光保存
Packing GroupI
Hazard Class6.1/3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,145,1967

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 249,55,1991

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 231,205,1990

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   46,277,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 172,105,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,269,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 92,427,1982

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Restrict 危险品

其他信息

  • 方法一:将1000ml1，3-二溴-2-丙醇和1500ml水混匀，分次加入400g氢氧化钙（88%），边加边搅拌。然后再一次加入400g氢氧化钙，减压蒸出环氧溴丙烷，馏出物经无水硫酸钠干燥，蒸馏，收集134-136℃馏分为成品，得1130-1200g，收率84-89%。
  • 储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂分开存放
  • TCI Shanghai:环氧溴丙烷 Epibromohydrin,>;97.0%(GC)(3132-64-7)
  • 毒性分级:高毒
  • 外观性质:无色或淡黄色透明液体, 易挥发。
  • 环氧溴丙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0011 环氧溴丙烷 Epibromohydrin 500G 824元 2014/06/02 E0011 环氧溴丙烷 Epibromohydrin 25G 291元
  • 可燃性危险特性:遇明火、高温、强氧化剂易燃; 受热分解有毒溴化氢气体
  • 用途二:有机合成中间体，溶剂。
  • 灭火剂:泡沫、二氧化碳、干粉、砂土、1211
  • MSDS 信息:环氧溴丙烷(3132-64-7).msds
  • 图谱信息:环氧溴丙烷(3132-64-7)红外图谱(IR1) 环氧溴丙烷(3132-64-7)质谱(MS) 环氧溴丙烷(3132-64-7)核磁图( 13 CNMR) 环氧溴丙烷(3132-64-7)Raman光谱 环氧溴丙烷(3132-64-7)红外图谱(IR2) 环氧溴丙烷(3132-64-7)核磁图( 1 HNMR)
  • MOL 文件:3132-64-7.mol
  • 上游原料:二溴
  • 急性毒性:腹腔- 大鼠 LD50: 300 毫克/ 公斤
  • 类别:易燃液体
  • Sigma Aldrich:3132-64-7(sigmaaldrich)
  • 用途一:用作有机合成中间体

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Epoxides - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Simple 3-Membered Ring Compounds 简单三元环化合物

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