Gamma-Butyrolactone γ -丁内酯(易制毒，不能销售)
CAS 96-48-0 MFCD00005386
化学结构图
SMILES: O=C1CCCO1
化学属性
| Mol. Formula | C4H6O2 |
|---|---|
| Mol. Weight | 86 |
| Density | 1.129 |
| Refractive index | 1.4360 to 1.4380 |
| Boiling Point | 80-81 |
| Melting Point | -45 |
| Autoignition Point | 851 °F |
| Vapor Density | 3 (vs air) |
| Vapor Pressure | 1.5 mmHg ( 20 °C) |
| Flash Point | 101°C(lit.) |
| Solubility | MISCIBLE |
| Stability | 对湿度敏感,对光线敏感 |
| pH | -:A |
| Danger-Level | - |
| Redox | - |
别名和识别编码
| Chemical Name | Gamma-Butyrolactone |
|---|---|
| CAS Number | 96-48-0 |
| Synonym | γ-丁内酯 γ-羟基丁酸 1,2-Butanolide 1,4-BUTANOLIDE 1,4-Butanolide 1-Oxacyclopentan-2-one 2,3,4,5-tetrahydro-2-furanone 2-Oxotetrahydrofuran 2-oxolanone 4-BUTYROLACTONE 4-HYDROXYBUTYRIC ACID GAMMA-LACTONE 4-Hydro 4-Hydroxybutanoic acid, γ-lactone 4-Hydroxybutyric acid lactone 4-butanolyde 4-deoxytetronic acid 4-hydroxybutanoic acid lactone 4-hydroxybutyric acid lactone ?-Hydroxybutyric Acid Lactone BLO BUTYROLACTONE,GAMMA- Butyric acid, 4-hydroxy-, gamma-lactone Butyryl lactone Dihydro-2(3H)-furanone FEMA 3291 GAMA-BUTYROLACTONE GAMMA-BUTYROLACTONE NCI-C55878 NIH 10540 dihydro-2(3H)-furanone {} {} {} {} |
| EC Number | 202-509-5 |
| Beilstein Registry Number | 105248 |
| MDL Number | MFCD00005386 |
| PubChem Substance ID | 7302 |
| Reaxys-RN | 105248 |
| Merck Number | 1596 |
| Alfabeta Name | DIHYDROFURANONEBUTYROLACTONE H23(())-- |
| Chemical Name Translation | γ -丁内酯(易制毒，不能销售) |
| Wiswesser Line Notation | T5OVTJ |
| InChI | InChI=1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {Chemicalbook} 农药中间体: 植物生长调节剂中间体
- B, Bioactive Small Molecules, Building Blocks, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Lactones, Nutrition Research, Organic Building Blocks, Other Biochemical, Phytochemicals by Chemical Classification
- {SNA} A-F, A-L, Alcoholic & Nonalcoholic Beverages, Analytical Standards, Beer, Coffee, Flavor and Fragrance Standards, Food & Beverage Standards, Food and Cosmetic Component Standards, Fruits, Furan / Furanone, Guava, Herbs & Spices, Lavender,
产品应用
- 气相色谱固定液(最高使用温度30℃，溶剂为甲醇)，分离分析烃类及各种含氧化合物、永久性气体。
- γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。。此外，还可用作电池、电容器制作，彩卷成色等。
- 生化上是γ-羟丁酸（GHB）的前体。它靠抑制多巴胺能神经元的冲动流阻止多巴胺释放。用γ-丁内酯预处理，能检测到自动受体诱导的多巴胺的释放。
相关文献及参考
- Koeltzow, T.E., Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J. Neurosci. 18 , 2231, (1998) 摘要
- Rodriguez-Bencomo, J., et al.: Eur. Food Res. Technol., 230, 485 (2010),
- 2. J. Power Sources 43 , 195, (1993)
- Mahalingam, A., et al.: J. Med. Chem., 53, 607 (2010),
- Merck: 14,1596 Beilstein:17,234
- Short: II/14a
- Merck: 14,1596
- Moon, J., et al.: J. Agric. Food Chem., 58, 5465 (2010),
- Merck 14 ,1596
安全信息
GHS Symbol
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H318 Causes serious eye damage 严重伤害眼睛
- H302 Harmful if swallowed 吞食有害
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P304+P340
- P304+P340+P312
- P305+P351+P338
- P305+P351+P338+P337+P313
- P308+P311
- P309+P311
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
- R22 Harmful if swallowed 吞咽有害
- R36 Irritating to eyes 刺激眼睛
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 191 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - adrenal cortex tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-406,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 gm/kg/42W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,41,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Behavioral - general anesthetic Lungs, Thorax, or Respiration - other changes REFERENCE : AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 13,70,1965
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5100 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534527
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1720 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GAFCC* GAF Material Safety Data Sheet. (
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Kidney DOSE/DURATION : 25 mg/L REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,638,1981
TYPE OF TEST : DNA damage TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 20 uL/disc REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,175,1981
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 2580 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,60,1989
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 4940 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,60,1989
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 25 gm/kg SEX/DURATION : male 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 10,239,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 500 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 62,57,1988
其他信息
- 类别:易燃物质
- 方法二:1.顺酐加氢法该法是70年代发展的先进工艺，用一段加氢反应，能以任意比例生产四氢呋喃和γ-丁内酯，通常的比例是四氯呋喃：γ-丁内酯=3-4：1。生产企业较多，但规模小，平均300t/a。该法产能占国内总产能的30%。2.1,4-丁二醇脱氢法反应器为列管式，装填片状的铜催化剂（以氧化锌为载体）。反应温度控制在230-240℃。反应产物粗γ-丁内酯经减压蒸馏而得成品，收率77%以上。
- 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） γ-丁内酯 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
- 海关编码:29322980
- 用途五:气相色谱固定液(最高使用温度30℃，溶剂为甲醇)，分离分析烃类及各种含氧化合物、永久性气体。重要的有机合成原料和优良溶剂。该产品可用于制造a-吡咯烷酮、N-甲基吡咯烷酮、聚乙烯吡咯烷酮，也是理想的抗氧剂、增塑剂、萃取剂、吸收剂、分散剂、固色剂、凝固剂；在医药行业可用作麻醉剂及镇静剂，可合成环丙沙星和干扰素等。是维生素、环丙胺等的中间体；在农林业方面也有广泛的用途，是生产植物生长剂、杀虫剂等的中间体。此外，还可用作电池、电容器制作，彩卷成色等。
- 毒性分级:中毒
- 用途四:γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。在有机合成中，GBL也有广泛的用途，它是合成α-吡咯烷酮、N-甲基吡咯烷酮、乙烯基吡咯烷酮、乙酰基-γ-丁内酯、环丙胺等的原料，是
- Acros Organics:gamma-丁内酯 gamma-Butyrolactone, 99+%(96-48-0)
- 图谱信息:gamma-丁内酯(96-48-0)红外图谱(IR1) gamma-丁内酯(96-48-0)核磁图
- 下游产品:四氢呋喃 --> N-甲基吡咯烷酮 --> 3-(2,2-二氯乙烯基)-2,2-二甲基环丙基羧酸甲基酯 --> 山梨酸 --> 环丙胺 --> 戊二酸 --> 二氯
- 急性毒性:口服-大鼠 LD50: 1540 毫克/公斤; 口服-小鼠 LD50: 1720 毫克/公斤
- gamma-丁内酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30032727 1，4-丁内酯;γ-丁内酯;4-羟基丁酸内酯 250ml 23元 2011/08/23 40006160 1，
- 下游产品:四氢呋喃 --> N-甲基吡咯烷酮 --> 3-(2,2-二氯乙烯基)-2,2-二甲基环丙基羧酸甲基酯 --> 山梨酸 --> 环丙胺 --> 戊二酸 --> 二氯菊酸乙酯 --> 环丙甲酸 --> 苯丁酸 --> 4-氯苯丁酮 --> 5-羟基-2-戊酮 --> 1-四氢萘酮 --> 2-吡咯烷酮 --> 3,3,4,4-二苯基砜四羧酸二酸酐 --> alpa-乙酰基-gama-丁酯 --> 泛酸钙 --> 3-吲哚丁酸 --> 2,6-二氟苯腈 --> ALPHA,ALPHA-二甲基-GAMMA-丁内酯 --> 4
- 蒸气压:1.5 mm Hg ( 20 °C)
- 和水完全可以互溶，可溶于乙醇、乙醚、 苯和丙酮，能溶解许多有机和无机化合物。在热碱溶液中分解。是一种沸点高、溶解性强、电性能及稳定性好的溶剂。使用安全、简便。有芳香气味。有吸湿性。能随水蒸气挥发。
- {C
- 用途四:γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。在有机合成中，GBL也有广泛的用途，它是合成α-吡咯烷酮、N-甲基吡咯烷酮、乙烯基吡咯烷酮、乙酰基-γ-丁内酯、环丙胺等的原料，是合成杀虫剂、除草剂、药物脑复康、环丙氟哌酸、维生素B1，叶绿素等的中间体。还用于合成氯苯氧基丁酸类除莠剂，植物生长调节剂。
- {Chemic
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