• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Bioactive Small Molecules, E,
• {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Core Bioreagents, Enzyme Inhibitors, Research Essentials, 细胞信号转导和神经科学, 细胞生物学
• {SNA} Core Bioreagents, Enzyme Inhibitors, Research Essentials
• Heterocycles
• {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents, E, Enzyme Inhibitors, Research Essentials
• {SNA} A to C, Apoptosis Enzymes, Apoptosis Inhibitors, Apoptosis and Cell Cycle, Application Index, Broa

产品应用

• 1、蛋白质半胱氨酸残基的共价修饰试剂。
• 2、巯基烷化试剂，使依赖于NADP的异柠檬酸脱氢酶和许多的内切酶失活。
• 3、在交感神经元中增加来自于M-通道的电流，并作为KCNQ2, KCNQ4 和 KCNQ5通道的开放者（opener）行施作用。

相关文献及参考

• [2]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.
• [3]. Choo YS, et al. Detection of protein ubiquitination. J Vis Exp. 2009;(30):1293. Published 2009 Aug 19. doi:10.3791/1293
• Merck: 14,3822
• Merck: 14,3822 Beilstein:21,399
• Reactive dienophile and dipolarophile. Reagent for modification of sulfhydryl groups of cysteine residues in proteins: Methods Enzymol., 25, 449 (1972); Eur. J. Biochem., 145, 245 (1984).
• Sheehan, M., et al.: J. Cell Biol., 106, 1
• [1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;2
• [1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9.

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1669 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,534,1972

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,534,1972

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 2 umol
REFERENCE :
   MAGDA3 Mechanisms of Ageing and Development.  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.1-    1972-
   Volume(issue)/page/year: 8,363,1978

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 300 umol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 106,1448,1982

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 750 nmol/L
REFERENCE :
   32YWA5 "Radiation Research, Biomedical, Chemical, and Physical Perspectives,
   Proceedings of the International Congress of Radiation Research, 5th,
   Seattle, 1974,"  Nygaard, O.F., et al., eds., New York, Academic Press,
   Inc., 1975  Volume(issue)/page/year: -,742,1975

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 30 umol/L
REFERENCE :

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 6 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1414,1980

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 6 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1414,1980

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其他信息

• MOL 文件:128-53-0.mol
• F:19
• 外观性质:无色结晶，易溶于醇及醚，微溶于水。有刺激性，催泪。 溶解度:1 g/l 水(20°C)，1115 g/l 甲苯(20°C)。熔点：46℃ 沸点: 210℃ 乙醇中溶解度：50 mg/ml. 水中溶解度：>50 mg /4 ml；然而，水溶液不稳定。水解速率准一级，并且显著依赖于pH值。
• Acros Organics:N-乙基马来酰亚胺 N-Ethylmaleimide, 99+%(128-53-0)
• 易溶于醇及醚，微溶于水。有刺激性，催泪。
• 存储注意事项:氮气保护
• 用途一:1、蛋白质半胱氨酸残基的共价修饰试剂。2、巯基烷化试剂，使依赖于NADP的异柠檬酸脱氢酶和许多的内切酶失活。3、在交感神经元中增加来自于M-通道的电流，并作为KCNQ2, KCNQ4 和 KCNQ5通道的开放者（opener）行施作用。
• TCI Shanghai:N-乙基顺丁烯二酰亚胺 N-Ethylmaleimide,>;98.0%(N)(128-53-0)
• Alfa Aesar:N-乙基马来酰亚胺,99+% N-Ethylmaleimide, 99+%(128-53-0)
• N-乙基马来酰亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30087232 N-乙基顺丁烯二酰亚胺(+4℃) 5g 165元 2011/04/16 E0136 N-乙基顺丁烯二酰亚胺 N-Ethylmaleimide 1G 187元 2011/04/16 E0136 N-乙基顺丁烯二酰亚胺 N-Ethylmaleimide 25G 1020元
• Sigma Aldrich:128-53-0(sigmaaldrich)
• 上游原料:马来酸酐 --> 乙胺 --> 石蜡油