• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} C-X Bond Formation (Halogen), Chemical Synthesis, Chlorination, Synthetic Reagents
• {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 5ring; amide; lactame; 1fragment

产品应用

• 有机合成中作氯化剂，抗菌素药物的中间体。

相关文献及参考

• Short: II/27C
• Source of positive chlorine in chlorination and oxidation reactions.
• Short: III/20a
• With dimethyl sulfide, forms the Corey-Kim reagent, a mild, selective oxidant for alcohols. For a review, see: Synthesis, 857 (1990); for tabulated examples, see: Org. Synth. Coll., 6, 220 (1988).
• Methyl ketones may be monochlorinated via their Li enolates: J. Org. Chem., 49, 1286 (1984). For the ɑ-chlorination of acid chlorides formed in situ, see: Tetrahedron Lett., 3235 (1974). For chlorination of deactivated anilines, see: Synthesis, 669 (1985).
• Merck: 14,2164 Beilstein:21,380
• Short: III/20c
• NCS in ether is a convenient alternative to hypochlorite for the conversion of amines to N-chloroamines, for use, e.g. in the Hofmann-Loeffler reaction, see: Chem. Ber., 88, 883 (1955).
• Primary alcohols are oxidized cleanly to aldehydes using NCS and a catalytic amount of TEMPO, A12733 under phase-transfer conditions: J. Org. Chem., 61, 7452 (1996).
• Merck: 14,2164
• In the presence of triphenylphosphine or triphenyl phosphite, converts alcohols to alkyl chlorides stereospecifically with inversion: Tetrahedron Lett., 3937 (1973). For a review, see: Org. React., 29, 1 (1983). Amides have been prepared by treatment of a carboxylic acid with NCS/PPh3 followed by an amine: Synth. Commun., 25, 959 (1995).

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 840 mg/kg/70W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   53,695,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PHRPA6 Public Health Reports.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402)  V.1-    1878-  Volume(issue)/page/year:
   59,541,1944

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHRPA6 Public Health Reports.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402)  V.1-    1878-  Volume(issue)/page/year:
   59,541,1944

其他信息

• Hazard Note:Irritant
• N-氯代丁二酰亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30196627 氯代丁二酰亚胺 250g 199.01元 2011/04/16 C0291 N-氯丁二酰亚胺 N-Chlorosuccinimide 500G 1240元 2011/04/16 C0291 N-氯丁二酰亚胺 N-Chlorosuccinimide 25G 160元
• 外观:浅黄至白色晶体.
• Sigma Aldrich:128-09-6(sigmaaldrich)
• TCI Shanghai:N-氯代丁二酰亚胺 N-Chlorosuccinimide,>;98.0%(T)(128-09-6)
• Acros Organics:N-氯化琥珀酰亚胺 N-Chlorosuccinimide, 97%(128-09-6)
• 溶解度:14 g/L水 (20°C)、1g/150ml 乙醇 和1g/50ml 苯，，稍溶于醚、氯仿和四氯化碳，溶于丙酮。1：50水溶液对石蕊呈酸性。有氯的气味
• 上游原料:氨 --> 氯 --> 次氯酸钠 --> 氯酸钠 --> 丁二酸 --> 次氯酸 --> 丁二酰亚胺
• 海关编码:29251995
• 用途三:主要应用在普通有机合成如制药,芳香剂合成,农化品中,也用于合成炔诺酮生物制药等有机合成中。N-氯代丁二酰亚胺（128-09-6）也可作为一种表面处理剂,改善有机合成纤维的性能,并使之不易褪色。
• 方法一:由丁二酸经氨化、氯化而得。将丁二酸加入的反应锅，滴加氨水，搅拌加热，在102℃蒸去水分。真空蒸馏，收集180℃以后馏分，得丁二酰亚胺。将熔化的丁二酰亚胺加至乙酸水溶液中，搅拌冷却至0-5℃，滴加次氯酸钠，控制在8℃以下反应（否则有爆炸危险）。反应液澄清时即达终点，离心，滤饼用水洗至中性，甩干，干燥，得成品。
• 存储注意事项:光敏感;湿度敏感
• 检测方法:T,NMR
• 企业检测指标参考:有效氯≥26 熔点148-153(℃) 干燥失重≤1 硫分最高0.2% 自由酸最高0.02%
• 用途二:有机合成中作氯化剂，抗菌素药物的中间体。
• MOL 文件:128-09-6.mol
• F:21
• Alfa Aesar:N-氯丁二酰胺,99% N-Chlorosuccinimide, 98%(128-09-6)
• 用途一:用作医药中间体、有机合成氯化剂，也可用于制备橡胶助剂
• MSDS 信息:Chlorosuccinimide(128-09-6).msds
• 下游产品:2-氯喹啉 --> 3-氨基-4-羟基吡啶盐酸盐 --> (+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯并吡咯烷-1-甲酸 --> 头孢克洛(一水物) --> 2-氯-4-氨基苯胺 --> 4'-溴-3'-氟乙酰苯胺 --> 2-氯-4-(三氟甲基)苯磺酰氯 --> 5-氨基-2,3-二氯吡啶 --> 5-甲基呋喃-2-硼酸 --> 3-(2,6-二氯苯基)-5-甲基异恶唑-4-甲醛 --> 5-甲基-3-苯基异恶唑-4-羧酸 --> 2-氨基-5-氯苯腈 --> 2-乙基环己酮 --> 5-硝基-2,3-二氯吡啶 --> 氟胺氰菊酯 --> 2-正丁基-4(5)-氯-5(4)-甲酰基咪唑 --> 2-氨基-4-苯基-5-噻唑甲酸乙酯 --> 5-硝基-2-羟基-3-氯吡啶
• 敏感性:Moisture Sensitive