2-Hydroxyisoindoline-1,3-dione N-羟基邻苯二甲酰亚胺

CAS 524-38-9 MFCD00005891

化学结构图

524-38-9
SMILES: O=C1c2ccccc2C(=O)N1O

化学属性

Mol. FormulaC8H5NO3
Mol. Weight163.13
Density1.638
Melting Point233°C
TSCAYes
Boiling Point370.3°C at 760 mmHg

别名和识别编码

Chemical Name2-Hydroxyisoindoline-1,3-dione
CAS Number524-38-9
Alfabeta NameHYDROXYISOINDOLEDIONE HH21132()-----,
MDL NumberMFCD00005891
Synonym N-Hydroxyphthalimide {LY} N-Hydroxyphthalimide {} {LY} N-Hydroxyphthalimide {} {} {LY} N-Hydroxyphthalimide {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Hydroxyphthalimide {} {} {} {} {} {} {} {} {} {} {}
EC Number208-358-1
Beilstein Registry Number131208
PubChem Substance ID10665
Merck Number14,4838
Reaxys-RN131208
Chemical Name TranslationN-羟基邻苯二甲酰亚胺
Wiswesser Line NotationT56 BVNVJ CQ
LabNetwork Molecule IDLN00159434
InChIInChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)8(11)9(7)12/h1-4,12H
Canonical SMILESO=C1C2=C(C(N1O)=O)C=CC=C2
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 5ring; 6ring; 9ring; amide; lactame; 1fragment
  • {SNA} Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Synthetic Reagents

产品应用

  • 用作阿米卡星等药物中间体。

相关文献及参考

  • O-Alkylation followed by hydrazinolysis gives O-alkylhydroxylamines: Bull. Soc. Chim. Fr., 833 (1976). Copper-promoted coupling with arylboronic acids, followed by hydrazinolysis, affords O-arylhydroxylamines: Org. Lett., 3, 139 (2001).
  • Merck: 14,4838
  • O-Alkylation followed by hydrazinolysis gives O-alkylhydroxylamines: Bull. Soc. Chim. Fr., 833 (1976). Copper-promoted coupling with arylboronic acids, followed by hydrazinolysis, affords O-arylhydroxylamines: Org. Lett., 3,
  • Short: EINECS
  • Short: III/31a
  • Merck: 14,4838 Beilstein:21,500
  • Efficient electron carrier for electrochemical oxidation of alcohols: J. Chem. Soc., Chem. Commun., 479 (1983). Has also been found to be an efficient catalyst for non-electrochemical oxidation of benzylic groups in benzonitrile solution with atmospheric pressure oxygen: J. Org. Chem., 60, 3934 (1995). The method can be extended to alkanes by the use of a catalyst such as 0.5-1 mol% Co(acac)2. Thus cyclohexane is oxidized to cyclohexanone and adipic acid; adamantane gives mainly 1-adamantanol with minor amounts of 2-adamantanone and 1,3-adamantanediol: J. Org. Chem., 61, 4520 (1996). Under similar conditions alkynes can be oxygenated to ɑß-acetylenic ketones in good yields: Chem. Commun., 2037 (1998).
  • Additive in the carbodiimide method of peptide coupling, leading to decreased racemization: J. Am. Chem. Soc., 89, 7151 (1967). For alternative reagents, see N,N'-Dicyclohexyl­carbodiimide, A10973, and Appendix 6.

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSTI5200000
Hazard Codes Xi
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00747

其他信息

  • 下游产品:邻-(2，3，4，5，6-全氟苯基)羟基氨，盐酸盐 --> 1,3-金刚烷二醇 --> 1-金刚烷醇 --> 合成鞣剂HV --> 合成鞣剂742号 --> 5-羟基对萘醌
  • Acros Organics:N-羟基邻苯二甲酰亚胺 N-Hydroxyphthalimide, 98%(524-38-9)
  • TCI Shanghai:N-羟基苯邻二甲酰亚胺 N-Hydroxyphthalimide,>;99.0%(T)(524-38-9)
  • 海关编码:29251995
  • Sigma Aldrich:524-38-9(sigmaaldrich)
  • 用途一:用作阿米卡星等药物中间体，也用作烷基氧化剂、催化剂、选矿捕收剂
  • 外观性质:白色至淡黄色针状结晶粉末。熔点:233-235 °C
  • N-羟基邻苯二甲酰亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010092 N-羟基邻苯二甲酰亚胺（NOP） 100g 220元 2011/04/16 H0395 N-羟基苯邻二甲酰亚胺 N-Hydroxyphthalimide 500G 1460元 2011/04/16 H0395 N-羟基苯邻二甲酰亚胺 N-Hydroxyphthalimide 25G 182元
  • Alfa Aesar:N-羟基邻苯二甲酰亚胺,98+% N-Hydroxyphthalimide, 98+%(524-38-9)
  • 用途二:用作阿米卡星等药物中间体。
  • 图谱信息:N-羟基邻苯二甲酰亚胺(524-38-9)红外图谱(IR1) N-羟基邻苯二甲酰亚胺(524-38-9)质谱(MS) N-羟基邻苯二甲酰亚胺(524-38-9)红外图谱(IR2)
  • 检测方法:HPLC,NMR
  • MOL 文件:524-38-9.mol
  • MSDS 信息:N-Hydroxyphthalimide(524-38-9).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indolines 吲哚啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Active Esters/Additives - Coupling
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Active Esters/Additives - Peptide Coupling
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Condensation & Active Esterification
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Oxidation - Synthetic Reagents
  4. Environmentally-friendly Oxidation
  1. Functional Group 官能团索引
  2. hydroxamic acid
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Peptide Synthesis

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