Strychnine 番木鳖碱

CAS 57-24-9 MFCD00005941

化学结构图

57-24-9
SMILES: O=C1C[C@@H]2OCC=C3CN4CC[C@]56c7ccccc7N1[C@H]5[C@H]2[C@H]3C[C@H]46

化学属性

Mol. FormulaC21H22N2O2
Mol. Weight334.41
Melting Point284-286 °C(lit.)
Solubilitychloroform: clear to hazy

别名和识别编码

Chemical NameStrychnine
Synonym (-)-STRYCHNINE (-)-Strychnine (-)-番木鳖碱 2,4a,5,5a,7,8,15,15a,15b,15c-decahydro-4,6-methano-6h,14h-indolo[3,2,1-ij]oxep 2,4a,5,5a,8,15,15a,15b,15c-Decahydro-4,6-methano-14H,16H-indolo(3,2,1-ij)oxepino(2,3,4-de)pyrolo(2,3-h)chinolin-14-on 4,6-Methano-6H,14H-indolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline, strychnidin-10-one deriv. Certox Dolco mouse cereal Kwik-Kil L-STRYCHNINE Mole death Mouse-Nots Mouse-Rid Mouse-Tox Nitrate, Strychnine Pied piper mouse seed Ro-Dex STRYCHNINE STRYCHNINE ALKALOID STRYCHNINE HEMISULFATE STRYCHNINE HEMISULFATE SALT STRYCHNINE HEMISULFATE SALT CRYSTALLINE STRYCHNINE SULFATE STRYCHNINE SULFATE HYDR
MDL NumberMFCD00005941
PubChem Substance ID441071
Beilstein Registry Number52979
CAS Number57-24-9
EC Number200-319-7
Chemical Name Translation番木鳖碱
Merck Number8855
InChIInChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
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分类

  • {SNA} Analytical Standards,
  • {Chemicalbook} 生物化学品: 生化试剂: 生物碱
  • Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Avicides, Chromatography, Doping Substances, Environmental Standards, Forensic and Veterinary Standards, Pesticides, Pesticides & Metabolites, Q-Z, Rodenticides, S, SN - SZ, Stimulans
  • {uni_hamburg} no charge; oxygen heterocycle; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 5ring; 6ring; 7ring; 8ring; 9ring; 10ring; 11ring; 12ring; 13ring; 14ring; 15ring; 16ring; 17ring; 18ring; 19ring; 21ring; 22ring; spiro; amide; lactame; ether; chiral; 1fragment
  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Resolution Reagents, Chiral Resolving Reagents, GABA and Glycine Receptor Modulators

相关文献及参考

  • White, W.F., The glycine receptor in the mutant mouse spastic (spa): strychnine binding characteristics and pharmacology. Brain Res. 329 , 1, (1985)
  • Merck 14 ,8855
  • Beil. 27 ,IV,7530
  • Aldrich MSDS 1 , 1620:A / Corp MSDS 1 (2), 3180:C / FT-IR 2 (3), 4262:A / FT-IR 1 (2), 1066:B / FT-NMR 1 (3), 613:A / IR-Spectra (2), 1291:H / IR-Spectra (3), 1509:G / NMR-Reference 2 (2), 942:D / RegBook 1 (2), 2881:L / Sax 6 , 2472 / Sigma FT-IR 1 (1), 603:C / Structure Index 1 , 461:B:5
  • Short: II/27B Title: Diamagnetic Susceptibility of Organic Compounds, Oils, Paraffins and Polyethylenes Author: Kumar, M.; Gupta, R. Editor: Gupta, Radha Raman Source: Landolt-Börnstein, New Series Volume: II/27B Year: 2008 Keyword: diamagnetic susceptibility; organic compounds ISBN: 978-3-540-44359-9 (print) ISBN: 978-3-540-45860-9 (online) Internet Resource: doi:10.1007/978-3-540-45860-9 RefComment: VIII, 503 p. With CD-ROM., Hardcover RefComment: Written for: Scientists and researchers in the fields of physics, chemistry, materials science RefComment: Supplement and Revised Editon to II/16 Abstract: The volume II/27 has been divided into three subvolumes according to the classes of compounds: Subvolume A: Diamagnetic susceptibility and magnetic anisotropy of inorganic and organometallic compounds; Subvolume B: Diamagnetic susceptibility of organic compounds, oils, paraffins and polyethylenes; Subvolume C: Diamagnetic susceptibility and magnetic anisotropy of organic compounds. The data presented in this volume are based on the literature survey of the chemical abstracts up to 2005. The calculated values of diamagnetic susceptibility of organic compounds in the present subvolume II/27B are presented along with their experimental values. They have been calculated with the use of structural parameters in structural formula by using different theoretical methods avail

安全信息

RTECSWL2275000
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P302+P350
  • P307+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Hazard Codes T+,N T+;N
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S13 Keep away from food, drink and animal foodstuffs 远离食品、饮料和动物饲料保存；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
Risk Statements
  • R50/53
  • R27/28 Very toxic in contact with skin and if swallowed 皮肤接触及吞食都有剧毒
  • R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
UN Number 1692 UN 1692 6.1/PG 1
Packing GroupI
Hazard Class6.1(a)
Storage condition Poison room
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品

其他信息

  • 中毒症状:通过对中枢神经系统细胞的直接作用，主要是对脊髓的直接兴奋作用而引起强烈的癫痫样惊厥最终引起肺功能障碍死亡。
  • TCI Shanghai:硫酸马钱子碱五水化合物 Strychnine Sulfate Pentahydrate,>;97.0%(T)(60-41-3)
  • 马钱子碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80119734 番木鳖碱（剧毒） 6g 129.9元 2010/06/21 158950250 马钱子碱 (-)-Strychnine 98% 25 GR 569元 2010/06/21 158951000 马钱子碱 (-)-Strychnine 98% 100 GR 1743元
  • MSDS 信息:马钱子碱(57-24-9).msds
  • 储运特性:库房通风低温干燥; 与食品分开储运
  • 图谱信息:马钱子碱(57-24-9)核磁图( 1 HNMR) 马钱子碱(57-24-9)质谱(MS) 马钱子碱(57-24-9)红外图谱(IR2) 马钱子碱(57-24-9)核磁图( 13 CNMR) 马钱子碱(57-24-9)红外图谱(IR1)
  • MOL 文件:57-24-9.mol
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • Sigma Aldrich:60-41-3(sigmaaldrich)
  • 可燃性危险特性:可燃;火场释放有毒氮氧化物烟雾
  • 类别:有毒物品
  • 毒性分级:剧毒
  • 参考质量标准:含量≥98%；比旋光度[α] 20 D -105°；并检测马钱子碱、灼烧残渣等杂质含量。
  • 用途一:拆分试剂，锑、砷、溴、铈、汞、锇、氯酸盐及硝酸盐的分析；临床用于巴比妥类药物的解毒作用。
  • 急性毒性:口服- 大鼠 LD50 2.35 毫克/ 公斤; 口服- 小鼠 LD50: 2 毫克/公斤
  • 外观性质:无色粉末。
  • 可燃性危险特性:不易燃; 燃烧产生有毒氧化氮气体
  • 类别:有毒物质
  • 方法一:将番木鳖(马钱子)磨成细粉，苯回流，盐酸提取得粗品，再精制而成。
  • MOL 文件:60-41-3.mol
  • 灭火剂:水, 泡沫, 二氧化碳, 砂土
  • 急救治疗:若病人清醒，可服用活性炭。病人出现迟钝状或已开始出现惊厥，则要尽可能快地保护气管，控制惊厥，有效的抗惊厥剂为苯并二氮杂卓类药物
  • 急性毒性:口服-大鼠 LD50: 2.6 毫克/公斤; 口服-小鼠 LDL0: 8 毫克/公斤
  • Acros Organics:马钱子碱 (-)-Strychnine,98%(57-24-9)
  • 职业标准:STEL 0.15 毫克/立方米
  • 图谱信息:马钱子碱硫酸盐(60-41-3)红外图谱(IR2) 马钱子碱硫酸盐(60-41-3)红外图谱(IR1)
  • Sigma Aldrich:57-24-9(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Resolution Reagents - Asymmetric Synthesis
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Resolution Reagents - Asymmetric Synthesis
  4. Chiral Resolving Reagents - Chiral Resolution Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Alpha sort - Pesticides & Metabolites
  7. Q-Z - Alpha sort
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Optical Resolution
  1. Functional Group 官能团索引
  2. sulfuric acid
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Ion Channels
  5. Ligand-Gated Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Ion Channels
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Neuroscience
  5. Neurotransmission
  6. Neurotransmitters

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