2,2,6,6-Tetramethylpiperidine 2,2,6,6-四甲基哌啶

CAS 768-66-1 MFCD00005985

化学结构图

768-66-1
SMILES: CC1(C)CCCC(C)(C)N1

化学属性

Mol. FormulaC9H19N
Mol. Weight141.26
Boiling Point152°C at 760 mmHg
Density0.837
Refractive index1.4440 to 1.4460
Flash Point24°C
TSCAYes
Melting Point-59 °C
SolubilityMISCIBLE
Appearance 无色或淡黄色液体。
Danger-Level乙类

别名和识别编码

Chemical Name2,2,6,6-Tetramethylpiperidine
CAS Number768-66-1
Alfabeta NameTETRAMETHYLPIPERIDINE 2266-,,,
MDL NumberMFCD00005985
Synonym 2,2,6,6-Tetramethylpiperidine {LY} 2,2,6,6-Tetramethylpiperidine {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,6,6-Tetramethylpiperidine {} {} {} {} {} {} {} {} {}
EC Number212-199-3
Beilstein Registry Number103296
PubChem Substance ID13035
Reaxys-RN103296
Chemical Name Translation2,2,6,6-四甲基哌啶
Wiswesser Line NotationT6MTJ B1 B1 F1 F1
LabNetwork Molecule IDLN00130136
InChIInChI=1S/C9H19N/c1-8(2)6-5-7-9(3,4)10-8/h10H,5-7H2,1-4H3
Canonical SMILESCC1(NC(CCC1)(C)C)C
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分类

  • {SNA} Building Blocks, C9, Chemical Synthesis, Heterocyclic Building Blocks, Organic Bases, Piperidines, Synthetic Reagents
  • {SNA} Acids & Bases, Bases, Building Blocks, C9, Chemical Synthesis, Heterocyclic Building Blocks, Organic Bases, Piperidines, Synthetic Reagents
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; 1fragment

相关文献及参考

  • Lithiation gives a highly-hindered, non-nucleophilic strong base; see, e.g. Org. Synth. Coll., 6, 571 (1988); 9, 426 (1998); Tetrahedron, 50, 3099 (1994). For use in selective isomerization of epoxides to aldehydes, see: J. Chem. Soc., Chem. Commun., 2103 (1994). For a study of the influence of TMEDA and related chelating ligands on the solution structure of the lithiated base, see: J. Org. Chem., 62, 5748 (1997). The Mg derivative, obtained by reaction with n-BuMgCl, is also an effective strong base which has been used in the regioselective ortho-metallation of pyridine carbamates and carboxamides: J. Org. Chem., 60, 8414 (1995).
  • Short: III/35D3
  • Short: III/38B

安全信息

Warnings FLAMMABLE
Signal word
GHS Symbol
WGK Germany2
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R10 Flammable 易燃
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312
  • P301+P316
  • P301+P317
  • P301+P330+P331
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P302+P361+P354
  • P303+P361+P353
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSTN4220000
Packing GroupIII
UN Number
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes
Storage condition 2-8°C {LY} 2-8°C Air Sensitive Flammables area {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class3/6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 184,1707,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 184,1707,1959

其他信息

  • MOL 文件:768-66-1.mol
  • 2,2,6,6-四甲基哌啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1051 2,2,6,6-四甲基哌啶 2,2,6,6-Tetramethylpiperidine 25ML 290元 2014/06/02 T1051 2,2,6,6-四甲基哌啶 2,2,6,6-Tetramethylpiperidine 250ML 1320元 2010/06/21 151950100 2,2,6,6-四甲基哌啶 2,2,6,6-Tetramethylpiperidine 98% 10 GR 624元
  • Acros Organics:2,2,6,6-四甲基哌啶 2,2,6,6-Tetramethylpiperidine, 98%(768-66-1)
  • Alfa Aesar:2,2,6,6-四甲基哌啶,98+% 2,2,6,6-Tetramethylpiperidine, 98+%(768-66-1)
  • 图谱信息:2,2,6,6-四甲基哌啶(768-66-1)核磁图( 13 CNMR) 2,2,6,6-四甲基哌啶(768-66-1)红外图谱(IR1) 2,2,6,6-四甲基哌啶(768-66-1)Raman光谱 2,2,6,6-四甲基哌啶(768-66-1)质谱(MS) 2,2,6,6-四甲基哌啶(768-66-1)核磁图( 1 HNMR)
  • Sigma Aldrich:768-66-1(sigmaaldrich)
  • 海关编码:29333999
  • 检测方法:GC,NMR
  • 下游产品:5-氟-2-吡啶羧酸 --> 2-氯吡啶-3,4-二羧酸 --> 2,2,6,6-四甲基哌啶氧化物 --> 2-氰基-5-溴-苯硼酸新戊二醇环酯 --> (E)-5-(2-羰基乙烯)-2,4-二甲氧基嘧啶 --> 2,4-二甲氧基5-嘧啶-甲醛 --> 3-氰嘧啶-4-硼酸,95% --> 4-氰基吡啶-3-硼酸 --> 2-氰吡啶-3-硼酸,95%
  • MSDS 信息:HTMP(768-66-1).msds
  • TCI Shanghai:2,2,6,6-四甲基哌啶 2,2,6,6-Tetramethylpiperidine,>;98.0%(GC)(T)(768-66-1)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Bases - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  5. C9 - Piperidines