Cytosine 胞嘧啶

CAS 71-30-7 MFCD00006034

化学结构图

71-30-7
SMILES: Nc1ccnc(=O)[nH]1

化学属性

Mol. FormulaC4H5N3O
Mol. Weight111.10
Melting Point>300°C
TSCAYes
Solubility可溶
Density0.48
Appearance 白色结晶性粉末，微溶于水和醇，熔点300℃
Boiling Point208.2 °C at 760 mmHg

别名和识别编码

Chemical NameCytosine
MDL NumberMFCD00006034
CAS Number71-30-7
Synonym Cytosine {LY} Cytosine {} {LY} Cytosine {} {} {LY} Cytosine {} {} {} {LY} Cytosine {} {} {} {} {LY} Cytosine {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cytosine {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID597
Beilstein Registry Number2637
EC Number200-749-5
Merck Number2795
Alfabeta NameAMINOPYRIMIDINONE H421()---
Reaxys-RN2637
Chemical Name Translation胞嘧啶
LabNetwork Molecule IDLN00154027
InChIInChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
Canonical SMILESO=C1NC=CC(N)=N1
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分类

  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
  • {SA} Biochemicals and Reagents, Nucleosides, Nucleosides, Nucleotides, Oligonucleotides
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards G - H, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Nucleosides, 核苷，核苷酸和寡核苷酸, 生化试剂
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical S

产品应用

  • 生化研究。

相关文献及参考

  • [2]. Oh G, et, al. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Nat Commun. 2018 Feb 13;9(1):644.
  • Merck: 14,2795
  • Merck: 14,2795 Beilstein:24,314
  • [1]. Maxam AM, et, al. A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4.
  • [1]. Maxam AM, et, al. A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4.
  • [2]. Oh G, et, al. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Nat Commun. 2018 Feb 13;9(1):644.

安全信息

WGK Germany1
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSUW7350150
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Hazard Codes Xi
Warnings IRRITANT
Storage condition RT, protect from light {LY} RT, protect from light Store at RT. {} {LY} RT, protect from light {} {} {LY} RT, protect from light {} {} {} {LY} RT, protect from light {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect fr 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2222 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 207,504,1978

其他信息

  • Alfa Aesar:胞嘧啶,98+% Cytosine, 98+%(71-30-7)
  • 100℃失水,300℃时成棕色,320～325℃分解。溶于水，溶于碱和酸，微溶于乙醇、氯仿；不溶于乙醚和烃。
  • MSDS 信息:2-Oxy-4-amino pyrimidine(71-30-7).msds
  • Sigma Aldrich:71-30-7(sigmaaldrich)
  • Acros Organics:胞嘧啶 Cytosine, 99+%(71-30-7)
  • MOL 文件:71-30-7.mol
  • Hazard Note:Irritant
  • 用途一:用作药物中间体
  • 检测方法:HPLC
  • 胞嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65004533 胞嘧啶; 4-氨基-2-羟基嘧啶; 氧胞嘧啶; 胞嗪; 4-氨基-2-羟基嘧啶 10g 77元 2011/04/16 C0528 胞嘧啶 Cytosine 5G 567元 2011/04/16 C0528 胞嘧啶 Cytosine 25G 1690元
  • TCI Shanghai:胞嘧啶 Cytosine,>;98.0%(LC)(T)(71-30-7)
  • 下游产品:5-碘-2'-脱氧尿苷 --> 5-碘胞核嘧啶 --> 脑二磷胆碱 --> 西多福韦 --> 5-溴胞嘧啶 --> 4-氨基-5-溴-2-嘧啶醇

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleosides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleosides - Nucleosides, Nucleotides, Oligonucleotides
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  5. C4 to C5 - Pyrimidines
  1. C9 to C46
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. DNA / RNA Synthesis
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nucleosides, Nucleotides, Oligonucleotides
  4. Nucleoside Analogs
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)