2-Methylpyrazine 2-甲基吡嗪

CAS 109-08-0 MFCD00006142

化学结构图

109-08-0
SMILES: Cc1cnccn1

化学属性

Mol. FormulaC5H6N2
Mol. Weight94
Density1.026
Refractive index1.5030 to 1.5060
Boiling Point135°C
Melting Point-29 °C(lit.)
Flash Point50°C(lit.)
TSCAYes
Appearance 无色至微黄色液体,具有似牛肉加热时发生的香味和果仁及可可似香味,稀释至300 mg/kg时呈巧克力香味。沸点137℃。熔点-29℃,闪点50℃。混溶于水、乙醇、丙酮和大多数非挥发性油。

别名和识别编码

Chemical Name2-Methylpyrazine
MDL NumberMFCD00006142
CAS Number109-08-0
EC Number203-645-8
Beilstein Registry Number23,94
Synonym 2-Methyl-1,4-diazinen 2-甲基吡嗪
PubChem Substance ID7976
Reaxys-RN105778
Chemical Name Translation2-甲基吡嗪
Wiswesser Line NotationT6N DNJ B1
LabNetwork Molecule IDLN00221341
InChIInChI=1S/C5H6N2/c1-5-4-6-2-3-7-5/h2-4H,1H3
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分类

  • {Chemicalbook} 食品添加剂: 食用香料(增香剂): 天然等同香料和人造香
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, I-N, Kosher Certified Products, L-M, M-N
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, I - N, I-N, Kosher Certified Products, L-M, M-N
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products,
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Follows IFRA Guidelines,

相关文献及参考

  • Short: III/35B Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts and Coupling Constants for Fluorine-19 and Nitrogen-15 Author: Balasubramanian, M.; Gupta, R.R.; Jain, M.; Perumal, S. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35B Year: 1998 ISBN: 3-540-63275-1 ISBN: 978-3-540-63275-7 Internet Resource: DOI:10.1007/b55685 RefComment: VII, 242 pages. With CD-ROM. Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonance data. Chemical shifts and coupling constants of boron-11 and phosphorus-31 (subvol. A), fluorine-19 and nitrogen-15 (subvol. B), hydrogen-1 (subvol. C), and carbon-13 (subvol. D) compounds are tabulated together with the gross- and structure formulas and the most readily available solvents. Due to the large amount of the data merely chemical shifts are presented in the printed versions, and all the data, chemical shifts and coupling constants are provided on CO-ROM's.
  • Short: III/38B Title: Refractive Indices of Organic Liquids Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/38B Year: 1996 Keyword: organic compounds; refractive index; liquids ISBN: 3-540-60596-7 ISBN: 978-3-540-60596-6 Internet Resource: DOI:10.1007/b85533 RefComment: VII, 4210 pages, Hardcover Abstract: Volume III/38 Optical Constants provides critically evaluated data on refractive indices of inorganic and organic liquids and their wavelength dependence (dispension). Part A contains the inorganic, organometallic, and organononmetallic liquids, and the binary liquid mixtures (about 900 pure substances and their mixtures). Part B contains data of more than 7600 organic liquids.
  • Short: IV/13A1 Title: Vapor-Liquid Equilibrium in Mixtures and Solutions. Binary Liquid Systems of Nonelectrolytes. Part 1 Author: Wichterle, I.; Linek, J.; Wagner, Z.; Fontaine, J.-C.; Sosnkows

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R10 Flammable 易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P302+P352+P332+P313+P362+P364
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P370+P378
  • P241+P242+P243
  • P403+P235
RTECSUQ3675000
Packing GroupIII
UN Number 1993
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3
Hazard Class3
Storage condition Flammables area
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 3,249,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1820 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,244,1970

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2500 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,581,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 8500 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,581,1980

其他信息

  • 用途一:用于染料及制药工业,也用作食品香料添加剂
  • 使用限量:FEMA(mg/kg):软饮料10;冷饮10;糖果10;焙烤食品10;布丁类10;乳制品10;肉类、沙司、汤10;谷类10。
  • 下游产品:2,3,5,6-四甲基吡嗪 --> 2-羧基-5-甲基吡嗪
  • 上游原料:乙二胺 --> 丙酮醛 --> 2-甲基哌嗪
  • MSDS 信息:2-Methylpyrazine(109-08-0).msds
  • 检测方法:GC,NMR
  • Acros Organics:2-甲基吡嗪 2-Methylpyrazine, 99+ %(109-08-0)
  • 图谱信息:2-甲基吡嗪(109-08-0)核磁图( 1 HNMR) 2-甲基吡嗪(109-08-0)Raman光谱 2-甲基吡嗪(109-08-0)核磁图( 13 CNMR) 2-甲基吡嗪(109-08-0)红外图谱(IR1) 2-甲基吡嗪(109-08-0)质谱(MS)
  • Alfa Aesar:2-甲基哌嗪,99+% 2-Methylpyrazine, 99+%(109-08-0)
  • 方法一:由2-甲基哌嗪催化脱氢而成。 由丙酮醛与乙二胺缩合而成。
  • 海关编码:29339990
  • 用途三:该品是我国 GB2760-86规定为允许使用的食用香料。主要用来配制肉类、巧克力、花生和爆玉米花等型香精。
  • Sigma Aldrich:109-08-0(sigmaaldrich)
  • 参考质量标准:FCC,1996 含量 ≥99.0% 折射率(n D 20 ) 1.504~1.506 相对密度(d 25 25 ) 1.010~1.030 水分 ≤0.5%
  • 2-甲基吡嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0736 2-甲基吡嗪 2-Methylpyrazine 25ML 302元 2014/06/02 M0736 2-甲基吡嗪 2-Methylpyrazine 250ML 1570元 2010/06/21 127550250 2-甲基吡嗪 2-Methylpyrazine 99+ % 25 GR 236元
  • 用途二:GB 2760--1996规定为允许使用的食用香料。主要用以配制肉类、巧克力、花生和爆玉米花等型香精。
  • MOL 文件:109-08-0.mol
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/kg) 最大允许残留量(g/kg) 2-甲基吡嗪 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 含量分析:按GT-10-4中用极性柱进行气相色谱法分析。
  • FEMA:3309
  • 方法二:由2-甲基哌嗪催化脱氢或由丙酮醛与乙二胺缩合都可以制得2-甲基吡嗪。
  • 毒性:GRAS(FEMA)。 LD501800 mg/kg(大鼠,经口)。
  • TCI Shanghai:2-甲基吡嗪 2-Methylpyrazine,>;98.0%(GC)(109-08-0)

系列性分类


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