2,3,5,6-Tetramethylpyrazine 2,3,5,6-四甲基吡嗪

CAS 1124-11-4 MFCD00006146

化学结构图

1124-11-4
SMILES: CC1NC(C)C(C)NC1C

化学属性

Mol. FormulaC8H12N2
Mol. Weight136.19
Density1.08
Boiling Point190 °C at 760 mmHg
Melting Point77-80°C
TSCAYes
Flash Point190°C
Appearance 白色晶体,密度 1.08 ,熔点 82-86℃,沸点 190 ℃

别名和识别编码

Chemical Name2,3,5,6-Tetramethylpyrazine
CAS Number1124-11-4
Alfabeta NameTETRAMETHYLPYRAZINE 2356-,,,
MDL NumberMFCD00006146
Synonym Ligustrazine {LY} Ligustrazine {} {LY} Ligustrazine {} {} {LY} Ligustrazine {} {} {} {LY} Ligustrazine {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ligustrazine {} {} {} {} {} {} {} {} {} {} {}
EC Number214-391-2
Beilstein Registry Number113100
PubChem Substance ID14296
Reaxys-RN113100
Chemical Name Translation2,3,5,6-四甲基吡嗪
Wiswesser Line NotationT6N DNJ B1 C1 E1 F1
LabNetwork Molecule IDLN00174759
InChIInChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
Canonical SMILESCC1=C(C)N=C(C)C(C)=N1
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分类

  • {SNA} Alcoholic & Nonalcoholic Beverages,
  • {SNA} Alcoholic & Nonalcoholic Beverages, All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Animal Products, Beef, Chromatography, Coffee,
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Certified Natural Products, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products, O-Z,
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Certified Natural Products, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products, O - Z, O-Z, Q-Z, R-Z
  • {S

相关文献及参考

  • Has been used as a component of a buffer to control the acid-catalyzed ring-opening of epoxides: J. Chem. Soc., Perkin 2, 1309 (1972).
  • Short: III/20a
  • Short: III/31a
  • Beilstein:23,99

安全信息

Warnings IRRITANT
Signal word Danger Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSUQ3905000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 239 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMJODS Chinese Medical Journal (Beijing, English Edition).  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1975-    Adopted vol. no. 92 in 1979.  Volume(issue)/page/year: 4,319,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1910 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 3,249,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
   Volume(issue)/page/year: 23,119,1985

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • FEMA:3237
  • 用途二:GB 2760—1996:允许使用的食用香料。主要用以配制肉类和可可、花生、坚果、咖啡、巧克力等型香精。
  • MOL 文件:1124-11-4.mol
  • TCI Shanghai:2,3,5,6-四甲基吡嗪 2,3,5,6-Tetramethylpyrazine,>;98.0%(GC)(T)(1124-11-4)
  • 图谱信息:2,3,5,6-四甲基吡嗪(1124-11-4)质谱(MS) 2,3,5,6-四甲基吡嗪(1124-11-4)红外图谱(IR2) 2,3,5,6-四甲基吡嗪(1124-11-4)核磁图( 13 CNMR) 2,3,5,6-四甲基吡嗪(1124-11-4)红外图谱(IR1)
  • Acros Organics:四甲基吡嗪(川芎嗪) Tetramethylpyrazine, 98%(1124-11-4)
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/kg) 最大允许残留量(g/kg) 2,3,5,6-四甲基吡嗪 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 用途三:用于药物生产。
  • Alfa Aesar:2,3,5,6-四甲基哌嗪,98+% 2,3,5,6-Tetramethylpyrazine, 98+%(1124-11-4)
  • MSDS 信息:Tetramethylpyrazine(1124-11-4).msds
  • 海关编码:29339990
  • 用途一:用作调味剂、酒精饮料的甜味增强剂、卷烟的矫味剂和增补剂
  • 方法一:由2,3-丁二酮和2,3-丁二胺缩合而成。
  • 上游原料:亚硝酸钠 --> 乙醇溶液 --> 2,3-丁二酮 --> 二酮 --> 四亚甲基二胺 --> 亚硝酸乙酯 --> 2-甲基吡嗪
  • 方法二:由丁酮与亚硝酸乙酯缩合生成丁二酮单肟,再经还原、环合而得甲甲基吡嗪。环合反应产物进行水蒸气蒸馏,馏出物冷却、结晶、过滤,得四甲基吡嗪粗品。精制时采用水重结晶和活性炭脱色。制备其盐酸盐时,可将其在丙酮中滴加含15%-20%氯化氢的乙醇溶液成盐。
  • 2,3,5,6-四甲基吡嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw050011 2,3,5,6-四甲基吡嗪 10g 380元 2011/04/16 T0972 2,3,5,6-四甲基吡嗪 2,3,5,6-Tetramethylpyrazine 25G 582元 2010/06/21 179910050 2,3,5,6-四甲基吡嗪 Tetramethylpyrazine 98% 5 GR 385元
  • Sigma Aldrich:1124-11-4(sigmaaldrich)

系列性分类


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