4-Acetylmorpholine 4-乙酰基吗啉

CAS 1696-20-4 MFCD00006171

化学结构图

1696-20-4
SMILES: CC(=O)N1CCOCC1

化学属性

Mol. FormulaC6H11NO2
Mol. Weight129.16
Density1.116
Refractive index1.4810 to 1.4850
Boiling Point255.9°C at 760 mmHg
Melting Point14°C
Flash Point>110°C
TSCAYes
SolubilityMISCIBLE

别名和识别编码

Chemical Name4-Acetylmorpholine
Synonym 1-Morpholinoethanone {LY} 1-Morpholinoethanone {} {LY} 1-Morpholinoethanone {} {} {LY} 1-Morpholinoethanone {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1-Morpholinoethanone {} {} {} {} {} {} {} {} {} {
CAS Number1696-20-4
EC Number216-913-4
Beilstein Registry Number111971
MDL NumberMFCD00006171
PubChem Substance ID87561797
Reaxys-RN111971
Chemical Name Translation4-乙酰基吗啉
InChIKeyKYWXRBNOYGGPIZ-UHFFFAOYSA-N
Wiswesser Line NotationT6N DOTJ AV1
LabNetwork Molecule IDLN00221413
Canonical SMILESCC(=O)N1CCOCC1
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分类

  • {uni_hamburg} no charge; oxygen heterocycle; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; amide; ether; 1fragment
  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 吗啉类杀菌剂
  • {SNA} Building Blocks, C4 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Morpholines/Thiomorpholines

产品应用

  • N-乙酰吗啉是非常重要农药中间体,是合成农用杀菌剂烯酰吗啉、氟吗啉的主要原料之一。N-乙酰吗啉和N-甲酰吗啉的混合物是优良的天然气和合成气酸性气体脱除剂。低品质的天然气或合成气的提取需要去除CO2和H2S等微量组分,对于CO2和H2S含量高的气体使用物理溶剂特别有利。

相关文献及参考

  • Beilstein: 27,IV,274
  • Short: EINECS
  • Short: III/38B
  • Short: IV/1a

安全信息

Signal word
GHS Symbol
WGK Germany1
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
  • P302+P352+P332+P313+P362+P364
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H315 Causes skin irritation 会刺激皮肤
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSQD7000000
Hazard Codes Xn Xi
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 7500 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CBCCT* "Summary Tables of Biological Tests," National Research Council
   Chemical-Biological Coordination Center.  (National Academy of Science
   Library, 2101 Constitution Ave., NW, Washington, DC 20418)
   Volume(issue)/page/year: 5,287,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CBCCT* "Summary Tables of Biological Tests," National Research Council
   Chemical-Biological Coordination Center.  (National Academy of Science
   Library, 2101 Constitution Ave., NW, Wash

其他信息

  • 无毒、无腐蚀。可以与水、低级醇混溶,易溶于一般的有机溶剂。N－乙酰吗啉在一般条件下化学性质稳定,热分解温度大于230℃ 。在热和强酸的作用下,可以发生酸解反应,生成吗啉盐和醋酸。
  • 毒性分级:中毒
  • 用途二:4-乙酰吗啉是杀菌剂烯酰吗啉、氟吗啉的中间体。
  • 4-乙酰基吗啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0102 4-乙酰基吗啉 4-Acetylmorpholine 25G 321元 2014/06/02 A0102 4-乙酰基吗啉 4-Acetylmorpholine 500G 2300元 2010/06/21 257200250 4-乙酰基吗啉 N-Acetylmorpholine 98% 25 ML 297元
  • 可燃性危险特性:可燃; 加热分解释放有毒氮氧化物烟雾
  • 类别:有毒物品
  • 爆炸物危险特性:与氧化剂反应激烈
  • Alfa Aesar:N-乙酰基吗啉,98% N-Acetylmorpholine, 98%(1696-20-4)
  • 用途三:N-乙酰吗啉是非常重要农药中间体,是合成农用杀菌剂烯酰吗啉、氟吗啉的主要原料之一。N-乙酰吗啉和N-甲酰吗啉的混合物是优良的天然气和合成气酸性气体脱除剂。低品质的天然气或合成气的提取需要去除CO2和H2S等微量组分,对于CO2和H2S含量高的气体使用物理溶剂特别有利。
  • Acros Organics:N-乙酰基吗啉 N-Acetylmorpholine, 98%(1696-20-4)
  • 刺激数据:皮肤-兔子 500 毫克/24小时 轻度; 眼睛-兔子 500 毫克 中度
  • 储运特性:库房通风低温干燥
  • 方法一:其制备方法是用吗啉与乙酰氯或乙酸酐反应而制得。
  • 用途一:是非常重要的农药中间体，是合成农用杀菌剂烯酰吗啉、氟吗啉的主要原料之一
  • Sigma Aldrich:1696-20-4(sigmaaldrich)
  • MOL 文件:1696-20-4.mol
  • 急性毒性:口服-大鼠 LD50: 6130 毫克/公斤; 非肠-小鼠 LDL0:2400 毫克/公斤
  • MSDS 信息:4-乙酰基吗啉(1696-20-4).msds
  • TCI Shanghai:4-乙酰基吗啉 4-Acetylmorpholine,>;99.0%(GC)(1696-20-4)
  • 上游原料:乙酐
  • 外观性质:黄色液体。
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  5. C4 to C10 - Morpholines/Thiomorpholines

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