2-Amino-3-benzyloxypyridine 2-氨基-3-苄氧基吡啶

CAS 24016-03-3 MFCD00006316

化学结构图

24016-03-3
SMILES: Nc1ncccc1OCc1ccccc1

化学属性

Mol. FormulaC12H12N2O
Mol. Weight200
Melting Point92-94
TSCANo
Density1.422

别名和识别编码

Chemical Name2-Amino-3-benzyloxypyridine
CAS Number24016-03-3
Synonym 3-(Phenylmethoxy)-2-pyridinamine 2-Pyridinamine, 3-(phenylmethoxy)- 3-Benzyloxy-2-pyridylamine 3-Benzyloxypyridin-2-amine 3-benzyloxy-2-pyridylamine NSC 298538 2-氨基-3-苄氧基吡啶 2-Amino-3-benzyloxy-pyridine 2-amino-3-benzyloxypyridine 3-Benzyloxy-2-aminopyridine [(3-(Benzyloxy)pyridin-2-yl])amine 3-Benzyloxy-pyridin-2-ylamine
MDL NumberMFCD00006316
PubChem Substance ID87560008
EC Number245-983-9
Beilstein Registry Number392674
Chemical Name Translation2-氨基-3-苄氧基吡啶
Reaxys-RN392674
InChIKeyNMCBWICNRJLKKM-UHFFFAOYSA-N
LabNetwork Molecule IDLN00009314
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分类

  • {SNA} A-AM, Bioactive Small Molecules, Building Blocks, C12, Cell Biology, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • Inhibitors
  • Heterocycles
  • Pharmaceuticals
  • Amines
  • {SNA} Building Blocks, C12, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; ether; 1fragment
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.

相关文献及参考

  • Jen, T., et al.: J. Med. Chem., 20, 1258 (1977),
  • Chung, D., et al.: Antican. Res., 11, 1373 (1991),
  • Short: III/35D3 Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Carbon-13, Part 3: Heterocycles Author: Gupta, R.R.; Jain, M.; Lechner, M.D.; Mikhova, B.M. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35D3 Year: 2007 Keyword: C-13; NMR; carbon-13; chemical shifts; coupling constants; heterocycles; nuclear magnetic resonance ISBN: 978-3-540-29731-4 ISBN: 3-540-29731-6 Internet Resource: DOI: 10.1007/978-3-540-47067-0 RefComment: VIII, 342 p., 1 illus., Hardcover RefComment: Written for Science and engineers in the fields of physics, chemistry and physical chemistry who inted to use NMR to study the structure and the binding of molecules Abstract: Nuclear Magnetic Resonance (NMR) is based on the fact that certain nuclei exhibit a magnetic moment, orient by a magnetic field, and absorb characteristic frequencies in the radiofrequency part of the spectrum. NMR is now a leading technique and a powerful tool for the investigation of the structure and interaction of molecules. The present Landolt-Börnstein volume III/35 Nuclear Magnetic Resonance (NMR) Data is therefore of major interest to all scientists and engineers who use NMR to study the structure and the binding of molecules. Volume III/35 "NMR-Data" is divided into several subvolumes and parts. Subvolume III/35A contains the nuclei B-11 and P-31, subvolume III/35B contains the nuclei F-19 and N-15, subvolume III/35C contains the nucleus H-1, subvolume III/35D contains the nucleus C-13, subvolume III/35E contains the nucleus O-17, and subvolume III/35G contains the nucleus Se-77. More nuclei are planned for future volumes.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Hazard Codes Xi

系列性分类


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