2,4,6-Collidine 2,4,6-三甲基吡啶

CAS 108-75-8 MFCD00006338

化学结构图

108-75-8
SMILES: Cc1cc(C)nc(C)c1

化学属性

Mol. FormulaC8H11N
Mol. Weight121.18
Refractive index1.4970 to 1.4990
Boiling Point171-172°C at 760 mmHg
Density0.916
Melting Point-43°C
Flash Point55°C
TSCAYes
Solubility溶于乙醇,可混溶于乙醚。
Stability对光敏感
pH:A

别名和识别编码

Chemical Name2,4,6-Collidine
Synonym 2,4,6-Trimethylpyridine {LY} 2,4,6-Trimethylpyridine {} {LY} 2,4,6-Trimethylpyridine {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4,6-Trimethylpyridine {} {} {} {} {} {} {} {} {}
CAS Number108-75-8
PubChem Substance ID7953
EC Number203-613-3
Beilstein Registry Number107283
MDL NumberMFCD00006338
Reaxys-RN107283
Merck Number9718
Chemical Name Translation2,4,6-三甲基吡啶
LabNetwork Molecule IDLN00155919
InChIInChI=1S/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H3
Canonical SMILESCC1=CC(C)=CC(C)=N1
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分类

  • {SNA} Building Blocks, C8, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography, Fixation Reagents, Fixatives, Hematology and Histology, Microscopy Reagents, Puriss p.a.,

产品应用

  • 无水碘化锂裂解位阻酯的有效溶剂。
  • 用作电子显微镜的组织固定剂。

相关文献及参考

  • Hindered base. For use in the dehydrochlorination of ɑ-chloroketones to enones, see: Org. Synth. Coll., 4, 162 (1963). For use in combination with Trifluoromethanesulfonic anhydride, A11767 for the generation of ketenimines from olefins, see N,N-Dimethyl­acetamide, A10924.
  • Merck:14,9718 Beilstein:20,250
  • Short: II/27B
  • Solvent for various O-alkyl cleavage reaction by LiI, including hindered esters: J. Org. Chem., 28, 2184 (1963), and methyl ethers of phenols: Chem. Commun., 616 (1969).
  • Merck 14 ,9718
  • Merck:14,9718
  • Superior base for peptide coupling reactions, causing less racemization than the more commonly used N-ethyldiisopropylamine or N-methylmorpholine: J. Org. Chem., 59, 695 (1994). For comparison with other hindered bases, see: J. Org. Chem., 61, 2460 (1996). For peptide reagents, see Appendix 6.

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 3 Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302+H332
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUU0970000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+
  • P302+P352+P312+P361+P364
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P337+P313
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 1992
Risk Statements
  • R10 Flammable 易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Packing GroupIII
Hazard Class3/6.1
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 ppm/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,847,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,847,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,847,1986

其他信息

  • 2,4,6-三甲基吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K2769201 2.4.6-三甲基吡啶 100ml 740元 2011/04/16 T0716 2,4,6-三甲基吡啶 2,4,6-Trimethylpyridine 25ML 175元 2011/04/16 T0716 2,4,6-三甲基吡啶 2,4,6-Trimethylpyridine 500ML 1210元
  • 用途一:用于有机合成
  • 用途三:主要用于制造口服避孕药(甲地孕酮),维生素A、维生素D3,氢化可的松及染料和植物生长激素等。
  • MOL 文件:108-75-8.mol
  • 具有弱碱性,微溶于水,溶于醇或醚。
  • Sigma Aldrich:108-75-8(sigmaaldrich)
  • 用途二:用作色谱分析标准物质,也用作溶剂,有机合成。
  • 上游原料:硫酸 --> 丙酮 --> 氨 --> 苯 --> 尿素 --> 氯化锌 --> 五氧化二磷
  • TCI Shanghai:2,4,6-三甲基吡啶 2,4,6-Trimethylpyridine,>;98.0%(GC)(108-75-8)
  • 外观性质:无色液体。
  • Acros Organics:2,4,6-三甲基吡啶 2,4,6-Collidine, 99%(108-75-8)
  • 图谱信息:2,4,6-三甲基吡啶(108-75-8)红外图谱(IR1) 2,4,6-三甲基吡啶(108-75-8)核磁图( 13 CNMR) 2,4,6-三甲基吡啶(108-75-8)质谱(MS) 2,4,6-三甲基吡啶(108-75-8)核磁图( 1 HNMR) 2,4,6-三甲基吡啶(108-75-8)红外图谱(IR2)
  • 下游产品:雌酚酮 --> 2-环戊烯酮
  • 检测方法:GC,NMR
  • Alfa Aesar:2,4,6-三甲基吡啶,99% 2,4,6-Collidine, 99%(108-75-8)
  • MSDS 信息:2,4,6-三甲基吡啶(108-75-8).msds
  • 海关编码:29333999
  • 敏感性:Hygroscopic

系列性分类