D-Glucose, 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]- 链脲菌素
CAS 18883-66-4 MFCD00006607
化学结构图
SMILES: CN(N=O)C(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O
化学属性
| Mol. Formula | C8H15N3O7 |
|---|---|
| Mol. Weight | 265 |
| Melting Point | 121 |
| Solubility | 可溶 |
| TSCA | No |
别名和识别编码
| Chemical Name | D-Glucose, 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]- |
|---|---|
| Synonym | 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose 2-Deoxy-2-(3-methyl-3-nitrosoureido)-alpha(and beta)-D-glucopyranose 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)- D-Glucose, 2-deoxy-2-(3-methyl-3-nitrosoureido)- N-(Methylnitrosocarbamoyl)--D-glucosamine N-(Methylnitrosocarbamoyl)-α-D-glucosamine N-d-Glucosyl(2)-N'-nitrosomethylharnstoff NSC-85598 NSC-85998 RCRA waste number U206 STRZ Streptozocin Streptozotocin Streptozotocin 链脲霉素 U-9889 Zanosar 链脲佐菌素 |
| PubChem Substance ID | 57654595 |
| EC Number | 242-646-8 |
| Beilstein Registry Number | 2060675 |
| MDL Number | MFCD00006607 |
| CAS Number | 18883-66-4 |
| Merck Number | 14,8832 |
| Wiswesser Line Notation | T6OTJ BQ CMVN1&NO DQ EQ F1Q -D,GLU |
| Chemical Name Translation | 链脲菌素 |
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分类
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Interferes with DNA Synthesis, Mechanism of Action, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Pfizer Compounds, S, 一氧化氮代谢, 一氧化氮和细胞应激, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学,
- {SNA} Antibiotics A to Z,
- {SNA} Antibiotics A to Z,
安全信息
GHS Symbol
- H350 May cause cancer 可能致癌
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P308+P313
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R22 Harmful if swallowed 吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R45 May cause cancer 可能致癌
- R46 May cause inheritable genetic damage 可能引起遗传基因损害
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 100 mg/kg/I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 51,1287,1973
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,563,1968
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors REFERENCE : CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 59,891,1975
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors REFERENCE : NNGZAZ Nippon Naibumpi Gakkai Zasshi. Journal of the Japan Endocrine Society. (Nippon Naibumpi Gakkai, c/o Kyoto-Furitsu Ika Daigaku, Kojinbashi Nis
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 1044 mg/kg/5D TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 34,993,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 13513 ug/kg TOXIC EFFECTS : Behavioral - toxic psychosis Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - body temperature increase REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 311,798,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,918,1976
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 440 mg/kg/65W-I TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from duodenum Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - changes in potassium REFERENCE : GUTTAK Gut. (British M
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 20 ng/plate REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 7500 mg/L REFERENCE : MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967- Volume(issue)/page/year: 174,39,1979
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 500 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,82,1979
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 20 mg/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3485,1987
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 200 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,3100,1988
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Scien
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 40 mg/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED Volume(issue)/page/year: 41,93,
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 35 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 14,373,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 40 mg/kg SEX/DURATION : female 5 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952- Volume(issue)/page/year: 19,610,1970
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