Bemegride 4-乙基-4-甲基哌啶-2,6-二酮

CAS 64-65-3 MFCD00006673

化学结构图

64-65-3
SMILES: CCC1(C)CC(=O)NC(=O)C1

化学属性

Mol. FormulaC8H13NO2
Mol. Weight155.20
Melting Point125.0 to 129.0 deg-C
Appearance powder 白色结晶性粉末或片状结晶，无臭、味苦。熔点127℃。在100℃、0.267kPa升华，溶于水、丙酮，略溶于乙醇。
SolubilityDMSO;Ethanol

别名和识别编码

Chemical NameBemegride
MDL NumberMFCD00006673
CAS Number64-65-3
Synonym 3-ETHYL-3-METHYLGLUTARIMIDE Eukraton 4-ETHYL-4-METHYL-2,6-PIPERIDINEDIONE 3-Ethyl-3-methylglutarimide 3-ethyl-3-methyl-glutarimid EUKRATON Bemegride Antibarbi NP13 贝美格 Agipnon Bemigride 4-Ethyl-4-methyl-2,6-dioxopiperidine 3-乙基-3-甲基戊二酰亚胺 METHETHARIMIDE Mikedimide 3,3-Methylethylilotarimide 2,6-Piperidinedione, 4-ethyl-4-methyl- BEMEGRIDE 美解眠 beta-Ethyl-beta-methylglutarimide 3-METHYL-3-ETHYLGLUTARIMIDE 贝美格;乙甲哌啶二酮;3-乙基-3-甲基戊二酰亚胺;美解眠;Np 13 NP-13 BETA-ETHYL-BETA-METHYLGLUTARIMIDE Bemegrid 2,6-Dioxo-4-methyl-4-ethylpiperidine Megimid 4-Ethyl-4-methyl-2,6-piperidinedione Megimide 2,6-DIOXO-4-METHYL-4-ETHYLPIPERIDINE Benegrid beta-Methyl-beta-ethylglutarimide Ahypnon B-METHYL-B-ETHYLGLUTARIMIDE 贝美格;乙甲哌啶二酮;3-乙基-3-甲基戊二酰亚胺 4-ethyl-4-methyl-6-piperidinedione 3-Methyl-3-ethylglutarimide 4-Methyl-4-ethyl-2,6-dioxopiperidine Malysol 乙甲哌啶二酮
PubChem Substance ID2310
EC Number200-588-0
Beilstein Registry Number21(1)335
Reaxys-RN116672
Merck Number1027
Chemical Name Translation4-乙基-4-甲基哌啶-2,6-二酮
Wiswesser Line NotationT6VMVTJ E2 E1
LabNetwork Molecule IDLN01343866
InChIInChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)
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品牌质保精细包装    现货库存    一流品牌服务   

产品应用

  • 中枢兴奋药。现主要用于解除巴比妥类、导眠能和水合氯醛等药的中毒，亦用于减少硫喷妥纳的麻醉的深度以加速其恢复

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P304+P340+P310
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P302+P350
  • P403+P233
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Hazard statements
  • H300+H310+H330
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H300 Fatal if swallowed 吞食致命
RTECSMA4550000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
UN Number UN 2811 6.1/PG 2 2811
Packing GroupII
Hazard Class6.1
Hazard Codes T
Storage condition -20°C 储存温度-20°C
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - gerbil
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 225,88,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 128,176,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,763,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - gerbil
DOSE/DURATION           : 22500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 227,106,1977

TYPE OF TEST            : L

其他信息

  • 贝美格价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0284 3-乙基-3-甲基戊二酰亚胺 3-Ethyl-3-methylglutarimide 10G 764元
  • Sigma Aldrich:64-65-3(sigmaaldrich)
  • 用途二:中枢兴奋药。现主要用于解除巴比妥类、导眠能和水合氯醛等药的中毒，亦用于减少硫喷妥纳的麻醉的深度以加速其恢复
  • 用途一:中枢兴奋药。现主要用于解除巴比妥类、导眠能和水合氯醛等药的中毒，亦用于减少硫喷妥纳的麻醉的深度以加速其恢复。
  • TCI Shanghai:3-乙基-3-甲基戊二酰亚胺 3-Ethyl-3-methylglutarimide,>;98.0%(T)(64-65-3)
  • color:white
  • Bemegride是一种中枢神经系统兴奋剂，及Barbiturate中毒的解毒剂。
  • MOL 文件:64-65-3.mol
  • 图谱信息:贝美格(64-65-3)Raman光谱 贝美格(64-65-3)核磁图( 1 HNMR) 贝美格(64-65-3)红外图谱(IR2) 贝美格(64-65-3)红外图谱(IR1) 贝美格(64-65-3)质谱(MS) 贝美格(64-65-3)核磁图( 13 CNMR)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Functional Group 官能团索引
  2. carboxylic acid imide, N-unsubstituted

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