4-Chloro-2-Phenylquinazoline 4-氯-2-苯基喹唑啉

CAS 6484-25-9 MFCD00006713

化学结构图

6484-25-9
SMILES: Clc1nc(-c2ccccc2)nc2ccccc12

化学属性

Mol. FormulaC14H9ClN2
Mol. Weight240.69
Melting Point124-126 °C
Boiling Point383.11 °C at 760 mmHg

别名和识别编码

Chemical Name4-Chloro-2-Phenylquinazoline
Synonym 4-Chloro-2-phenylquinazoline {LY} 4-Chloro-2-phenylquinazoline {} {LY} 4-Chloro-2-phenylquinazoline {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {}
MDL NumberMFCD00006713
PubChem Substance ID80977
CAS Number6484-25-9
EC Number229-346-2
Chemical Name Translation4-氯-2-苯基喹唑啉
InChIKeyOBHKONRNYCDRKM-UHFFFAOYSA-N
LabNetwork Molecule IDLN00239862
InChIInChI=1S/C14H9ClN2/c15-13-11-8-4-5-9-12(11)16-14(17-13)10-6-2-1-3-7-10/h1-9H
Canonical SMILESClC=1N=C(N=C2C=CC=CC12)C=3C=CC=CC3
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分类

  • Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinazolines
  • {SA} Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinazolines

相关文献及参考

  • 1. M. V. Papadopoulou, et al., Novel 3-nitro-1 H -1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents J. Med. Chem. 54 , 8214-8223, (2011)
  • 2. H. M. Shallal and W. A. Russu, Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives Eur. J. Med. Chem. 46 , 2043-2057, (2011)
  • 3. M. Nilsson, et al., Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents Bioorg. Med. Chem. Lett. 20 , 4004-4011, (2010)
  • 4. P. M. Chandrika, et al., Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines Indian J. Chem. B 48B , 840-847, (2009)
  • 5. D. Bebbington, et al., The discovery of the potent aurora inhibitor MK-0457 (VX-680) Bioorg. Med. Chem. Lett. 19 , 3586-3592, (2009)
  • 6. B. Sreedhar, et al., Nanocrystalline Titania-Supported Palladium(0) Nanoparticles for Suzuki-Miyaura Cross-Coupling of Aryl and Heteroaryl Halides Adv. Synth. Catal. 353 , 2823-2836, (2011)
  • 7. B. Sreedhar, et al., Catalyst-free and base-free water-promoted SNAr reaction of heteroaryl halides with thiols Synthesis 10 , 1732-1738, (2009)
  • J. Org. Chem. 37 , 1681, (1972)
  • J. Org. Chem. 29 , 1893, (1964)
  • Fieser 4 ,86
  • FT-IR 2 (3), 3948:A / FT-IR 1 (2), 881:C / FT-NMR 1 (3), 466:B / IR-Spectra (3), 1405:C / IR-Spectra (2), 1225:H / NMR-Reference 2 (2), 757:B / RegBook 1 (2), 2647:A / Structure Index 1 , 417:A:1

安全信息

WGK Germany3
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Warning
Storage condition -20°C, sealed storage, away from moisture {LY} -20°C, sealed storage, away from moisture {} {LY} -20°C, sealed storage, away from moisture {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, seal

其他信息

  • MOL 文件:6484-25-9.mol
  • 上游原料:甲醇 --> N,N-二甲基甲酰胺 --> 三氯氧磷 --> 碳酸钾 --> 铜 --> 苄脒盐酸盐 --> 2-溴苯甲酸
  • 4-氯-2-苯基喹唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 171931000 4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline 97% 100 GR 5443元 2010/06/21 171930050 4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline 97% 5 GR 530元 2010/06/21 171930250 4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline 97% 25 GR 2221元
  • Acros Organics:4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline, 97%(6484-25-9)
  • Sigma Aldrich:6484-25-9(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Quinazolines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Quinazolines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrrolidines

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