Lepidine 4-甲基喹啉

CAS 491-35-0 MFCD00006784

化学结构图

491-35-0
SMILES: Cc1ccnc2ccccc12

化学属性

Mol. FormulaC10 H9 N
Mol. Weight143.19
Density1.083
Refractive index1.6170 to 1.6210
Boiling Point
Melting PointNo Data Available
Flash Point>110°C
TSCAYes
Solubility略溶于水
Stability对光敏感

别名和识别编码

Chemical NameLepidine
CAS Number491-35-0
Alfabeta NameLEPIDINE
MDL NumberMFCD00006784
Synonym 4-Methylquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number207-734-2
Beilstein Registry Number110926
PubChem Substance ID87571993
Merck Number5441
Chemical Name Translation4-甲基喹啉
Reaxys-RN110926
Wiswesser Line NotationT66 BNJ E1
LabNetwork Molecule IDLN00171532
InChIInChI=1S/C10H9N/c1-8-6-7-11-10-5-3-2-4-9(8)10/h2-7H,1H3
Canonical SMILESCC1=CC=NC2=CC=CC=C12
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; 1fragment
  • {SNA} Alphabetical Listings, Flavors and Fragrances, M-N
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines

产品应用

  • 用作染料、医药、感光材料的中间体。

相关文献及参考

  • Short: II/27B
  • Lepidine and similar compounds can be alkylated at the 2-position by free radicals generated by the action of t-butyl hydroperoxide and a salt of Fe(II) on a primary or secondary alkyl iodide: Acta Chem. Scand., 43, 995 (1989). Similarly, 2-formylation can be achieved in high yield using 1,3,5-trioxane in the presence of TFA, t-BuOOH and FeSO4 in acetonitrile: J. Org. Chem., 51, 536 (1986).
  • Merck: 14,5441 Beilstein:20,395
  • Short: III/35B
  • Merck: 14,5441

安全信息

Warnings 危化品目录(2015) IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSOH0316000
Storage condition +4°C 4 4℃ Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes Xn Xi Xi,Xn 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,335,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,217,1991

Restrict 危险品

其他信息

  • 可燃性危险特性:受热分解有毒氧化氮气体
  • 检测方法:GC,NMR
  • 敏感性:Light Sensitive
  • 用途一:用作染料、医药、感光材料的中间体。
  • 灭火剂:二氧化碳、砂土、泡沫、水
  • 类别:有毒物品
  • Sigma Aldrich:491-35-0(sigmaaldrich)
  • Alfa Aesar:4-甲基喹啉,98% Lepidine, 98%(491-35-0)
  • 方法一:从煤油中回收可得到该品。重吡啶残渣油中精馏截取的260-267℃馏分段内含4-甲基喹啉35%-56%。将此馏分在酒精中与浓度为98%的浓硫酸反应，温度控制在35℃，生成磺酸盐，经冷却、结晶、过滤后，所得结晶用3倍重量的酒精重结晶，得熔点大于220℃的结晶，再用20%的深氨水在室温下分解至pH=8，得粗制4-甲基喹啉。然后在20块理论板的蒸馏塔蒸馏，切取262.3-266.8℃馏分，得纯度大于95%的4-甲基喹啉。
  • 上游原料:乙醇 --> 乙酸乙酯 --> 硫酸 --> 乙酸 --> 三氯氧磷 --> 氢氧化铵 --> 二甲苯 --> 氨基苯 --> 锌粉 --> 五氯化磷 --> 氯化锌 --> 碘 --> 红磷 --> 六水三氯化铁 --> N-乙酰乙酰苯胺 --> 丁烯酮
  • 存储注意事项:光敏感
  • 能与乙醇、乙醚、苯混溶，微溶于水,见光变成红棕色。
  • MOL 文件:491-35-0.mol
  • 图谱信息:4-甲基喹啉(491-35-0)核磁图( 13 CNMR) 4-甲基喹啉(491-35-0)质谱(MS) 4-甲基喹啉(491-35-0)红外图谱(IR1)
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 4-甲基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 A15828303 4-甲基喹啉99％ 100g 3637元 2011/04/16 L0024 勒皮啶 Lepidine 25ML 759元 2011/04/16 L0024 勒皮啶 Lepidine 500ML 7880元
  • MSDS 信息:4-甲基喹啉(491-35-0).msds
  • 外观性质:无色油状液体，遇光变成红棕色。
  • TCI Shanghai:4-甲基喹啉 Lepidine,>;97.0%(GC)(491-35-0)
  • 下游产品:喹啉-4-羧酸 --> 4-喹啉甲醛 --> 8-氨基喹啉-4-羧酸甲酯
  • F:8-10
  • Acros Organics:4-甲基喹啉 Lepidine, 99%(491-35-0)

系列性分类

  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. M-N - Alphabetical Listings
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  5. C8 to C10 - Quinolines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quinolines 喹啉

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