4-Amino-1,8-naphthalimide 4-氨基-1,8-萘二胺

CAS 1742-95-6 MFCD00006921

化学结构图

1742-95-6
SMILES: Nc1ccc2c3c(cccc13)C(=O)NC2=O

化学属性

Mol. FormulaC12H8N2O2
Mol. Weight212.20
Density1.105 g/mL at 25 °C(lit.)
Melting Point>360 °C
Boiling Point352.04 °C at 760 mmHg

别名和识别编码

Chemical Name4-Amino-1,8-Naphthalimide
MDL NumberMFCD00006921
PubChem Substance ID1720
CAS Number1742-95-6
EC Number217-110-1
Synonym 4-Aminonaphthalimide {LY} 4-Aminonaphthalimide 4-amino-1,8-naphthalimide 4-amino1,8-naphthalimide {} {LY} 4-Aminonaphthalimide {} {} {LY} 4-Aminonaphthalimide {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Aminonaphthalimide {} {} {} {} {} {} {} {} {} {} {
Chemical Name Translation4-氨基-1,8-萘二胺
InChIKeySSMIFVHARFVINF-UHFFFAOYSA-N
Beilstein Registry Number0177185
LabNetwork Molecule IDLN00844112
InChIInChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
Canonical SMILESO=C1NC(C2=CC=C(N)C3=CC=CC1=C23)=O
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分类

  • A-AM, Antitumor Agents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q, PARP (Poly(ADP-Ribose) polymerase), PARP Inhibitors, PARP Poly(ADP-ribose) Polymerase, Therapy Adjuncts
  • {SNA} Apoptos
  • {SNA} Apoptosis and Cell Cycle,
  • {SNA} Antitumor Agents, Apoptosis and Cell Cycle, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, P to Q, PARP (Poly(ADP-Ribose) polymerase), PARP Inhibitors, PARP Poly(ADP-ribose) Polymerase,

相关文献及参考

  • Bernges, F., and Zeller, W.J., Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin. J. Cancer Res. Clin. Oncol. 122 , 665-670, (1996) 摘要
  • Schlicker, A., et al., 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int. J. Radiat. Biol. 75 , 91-100, (1999) 摘要
  • Banasik, M., et al., Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J. Biol. Chem. 267 , 1569-1575, (1992) 摘要
  • RegBook 1 (2), 2079:K

安全信息

RTECSDE4081000
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P333+P313
  • P333+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes T Xi
GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R45 May cause cancer 可能致癌
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition -20°C, protect from light {LY} -20°C, protect from light 2-8°C, protect from light {} {LY} -20°C, protect from light {} {} {LY} -20°C, protect from light {} {} {} {LY} -20°C, protect from light {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, pr 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 42(1),111,1977

其他信息

  • Sigma Aldrich:6492-86-0(sigmaaldrich)
  • MOL 文件:6492-86-0.mol

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Antitumor Agents - Cancer Research
  4. Therapy Adjuncts - Antitumor Agents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Benzoxazines 苯恶嗪
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. PARP (Poly(ADP-Ribose) polymerase) - Apoptosis and Cell Cycle
  6. PARP Inhibitors - PARP (Poly(ADP-Ribose) polymerase)
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. PARP (Poly(ADP-Ribose) polymerase) - Apoptosis and Cell Cycle
  6. PARP Inhibitors - PARP (Poly(ADP-Ribose) polymerase)
  1. Functional Group 官能团索引
  2. carboxylic acid imide, N-unsubstituted
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Apoptosis and Cell Cycle
  5. PARP (Poly(ADP-Ribose) polymerase)
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Apoptosis and Cell Cycle Proteins
  6. PARP (Poly(ADP-Ribose) polymerase)
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Apoptosis Enzymes
  6. PARP (Poly(ADP-Ribose) polymerase)
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Papain
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Apoptosis and Cell Cycle Proteins
  6. PARP (Poly(ADP-Ribose) polymerase)

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