Glyoxylic acid 乙醛酸

CAS 298-12-4 MFCD00006958

化学结构图

298-12-4
SMILES: O=CC(=O)O

化学属性

Mol. FormulaC2H2O3
Mol. Weight74.04
Density1.3
Melting Point-93 °C
TSCAYes
Boiling Point111 °C at 760 mmHg
Refractive indexn20/D 1.4149
SolubilityMISCIBLE
Flash Point111°C
Appearance 白色固体。 水溶液为无色透明液体。 微溶于乙醇、乙醚和苯。

别名和识别编码

Chemical NameGlyoxylic acid
CAS Number298-12-4
Alfabeta NameGLYOXYLICACIDAQUEOUSSOLUTION %50()
MDL NumberMFCD00006958
EC Number206-058-5
Synonym Glyoxalic acid {LY} Glyoxalic acid {} {LY} Glyoxalic acid {} {} {LY} Glyoxalic acid {} {} {} {LY} Glyoxalic acid {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glyoxalic acid {} {} {} {} {} {}
PubChem Substance ID125307347
Beilstein Registry Number741891
Reaxys-RN741891
Merck Number4511
Chemical Name Translation乙醛酸
InChIKeyHHLFWLYXYJOTON-UHFFFAOYSA-N
Wiswesser Line NotationVHVQ
LabNetwork Molecule IDLN00174003
InChIInChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)
Canonical SMILESO=C(O)C=O
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分类

  • {SNA} Aldehydes, Building Blocks, C1 to C5, C1 to C6, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks
  • {SNA} Aldehydes, Amino Acid, Building Blocks, C1 to C5, C1 to C6, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Lipid, Lipid Library, Metabolic Libraries, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Organic Building Blocks, TCA

相关文献及参考

  • For use in aqueous hetero Diels-Alder reactions, see: Tetrahedron, 50, 10265 (1994).
  • Reagent for the facile deprotection of oximes in aqueous medium: Tetrahedron Lett., 45, 3161 (2004).

安全信息

Warnings IRRITANT
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
UN Number 3265
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
WGK Germany1
Precautionary statements
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P333+P313
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
GHS Symbol
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Signal word Danger
Packing GroupII
Hazard Codes 8 C
RTECSMD4550000
Hazard Class8
Storage condition Solution, -20°C, 2 years {LY} Solution, -20°C, 2 years {} {LY} Solution, -20°C, 2 years {} {} {LY} Solution, -20°C, 2 years {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 36,1937,1960

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   AJCPAI American Journal of Clinical Pathology.  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1931-
   Volume(issue)/page/year: 45,46,1966

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1500 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 189,217,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/plate
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 47,2461,1983

其他信息

  • TCI Shanghai:乙醛酸(约40%的水溶液,约6.9mol/L) Glyoxylic Acid (ca. 40% in Water, ca. 6.9mol/L)(298-12-4)
  • 用途二:乙醛酸是最简单的酮酸（醛酸），兼有酸和醛的性质，用作清漆原料，香料、医药、染料、塑料和家业化学品的中间体。可
  • 乙醛酸水合物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010426 乙醛酸,一水 25g 165元 2011/08/23 K5071001 乙醛酸一水合（+4℃） 50g 530元 2010/06/21 120170250 乙醛酸水合物 Glyoxylic acid monohydrate 98%, pure 25 GR 341元
  • 防护措施:本品有毒，有腐蚀性，能刺激皮肤和粘膜。40%产品大鼠经口LD50为70mg/kg。操作人员要注意穿戴好劳保用品，沾及皮肤时要用大量清水冲洗。
  • 上游原料:硝酸 --> 甲醇钠 --> 乙二醛 --> 草酸 --> 二氯乙酸 --> 甲氧基乙酸
  • 用途一:用作化妆品的调香剂和定香剂、用于制药
  • Acros Organics:乙醛酸(50%水溶液) Glyoxylic acid, 50% in water(298-12-4)
  • F:3
  • 下游产品:1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚,98%
  • 常规方法:玻璃瓶或透明塑料桶装。净重2kg、5kg、10kg、25kg和50kg。按有毒化学品规定贮运。
  • 用途二:乙醛酸是最简单的酮酸（醛酸），兼有酸和
  • 下游产品:香兰素 --> 对羟
  • 方法一:1.草酸电解法草酸水溶液经电解还原，生成乙醛酸稀溶液，然后经蒸发、浓缩、冷冻、过滤逐渐提浓，最后得合格品包装。2.乙二醛氧化法乙二醛在催化剂作用下经空气或氧气氧化，生成乙醛酸，然后经精制提纯得成品。另外，二氯乙酸与甲醇钠缩合得到二甲氧基乙酸钠，再用盐酸水解就生成乙醛酸。
  • MOL 文件:563-96-2.mol
  • MOL 文件:298-12-4.mol
  • 下游产品:香兰素 --> 对羟基苯甲醛 --> 乙基香兰素 --> N-甲基吗啡啉 --> 对羟基苯乙酸 --> 十八烷基二甲基叔胺 --> 舒林酸 --> 香草粉 --> 2-羟基喹喔啉 --> 缩节胺 --> D(-)-对羟基苯甘氨酸 --> DL-异丝氨酸 --> 尿囊素 --> 对羟基扁桃酸 --> 头孢唑肟 --> 2-氨基-2-苯基乙酸 --> 高香草酸 --> 胍立莫司 --> 4－羟基－3－甲氧基苦杏仁酸 --
  • Alfa Aesar:乙醛酸,50%w/w水溶液 Glyoxylic acid, 50% w/w aq. soln.(298-12-4)
  • Alfa Aesar:单水合乙醛酸,97% Glyoxylic acid monohydrate, 97%(563-96-2)
  • 乙醛酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 G0366 乙醛酸（约50%水溶液,约9mol/L） Glyoxylic Acid (ca. 50% in Water, ca. 9mol/L) 25ML 137元 2014/06/02 G0366 乙醛酸（约50%水溶液,约9mol/L） Glyoxylic Acid (ca. 50% in Water, ca. 9mol/L) 500ML 462元 2010/06/21 411060025 乙醛酸 Glyoxylic acid , 50% in water 2.5 KG 2321元
  • 乙醛
  • Sigma Aldrich:298-12-4(sigmaaldrich)
  • 用途二:乙醛酸是最简单的酮酸（醛酸），兼有酸和醛的性质，用作清漆原料，香料、医药、染料、塑料和家业化学品的中间体。可用于生产口服青霉素香兰素、乙基香兰素和尿囊素（见01320）。尿囊素是抗溃疡药

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Lipid Library - Metabolic Libraries
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Libraries
  5. Carbohydrate Library
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Libraries
  6. Carbohydrate Library
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Cofactor
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Porphyrin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  7. Cholesterol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  7. Porphyrin
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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