Pentachloronitrobenzene 五氯硝基苯

CAS 82-68-8 MFCD00007065

化学结构图

82-68-8
SMILES: O=[N+]([O-])c1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

化学属性

Mol. FormulaC6Cl5NO2
Mol. Weight295.33
Melting Point140-143 °C(lit.)
Boiling Point328°C
Density1.718 g/cm3 at 25 °C
Solubility不溶
Flash Point11 °C
Appearance powder

别名和识别编码

Chemical NamePentachloronitrobenzene
Synonym Marisan forte Q Fungiclor Folosan PCNB KOBUTOL FOLOSAN(R) RTU 1010 KP 2 NCI-C004 TRITISAN(R) Quinosan Avicol (pesticide) 掘地坐 Quintocene Pentachoronitrobenzene Batrilex Tri-pcnb {Ch GC 3944-3-4 { Terrazan F Tritisan Sa Fomac 2 Terrachlor PKhNb Fartox 硝基五氯苯 PCNB 五氯硝基苯 土粒散 Terrafun PCNB(R) RCRA waste number U185 {C pentachloronitrobenzene {Chemical Phomasan Terraclor Terraclor 30 G Quintozene {Chemicalb 五氯硝基苯原粉 Quintozen 'LGC' (1125) PCNB 土粒散 Brassico 五氯硝基苯 Brassicol super Brassicol PENT Pentachloronitrobenzene 硝基五氯苯,土粒散 Liro-PCNB avicol(pesticide) QUINTOZEN 土粒散 quintozin Earthcide 硝基五氯苯,土粒散;PCNB Tilcarex Chinozan 五氯硝基苯粉剂 Nitropentachlorobenzene Botrilex TERRACLOR Pentachloronitrobenzol 五氯硝苯 Terrazan FOLOSAN 2,3,4,5,6-Pentachloronitrobenzene Avicol 1,2,3,4,5 PKHNB Pentachlornitrobenzol Pentagen Pentachl Terraclor 30G {hazard_c
CAS Number82-68-8
PubChem Substance ID6720
EC Number201-435-0
Beilstein Registry Number1914324
MDL NumberMFCD00007065
Chemical Name Translation五氯硝基苯
Merck Number8080
Wiswesser Line NotationWNR BG CG DG EG FG
LabNetwork Molecule IDLN01291074
InChIInChI=1S/C6Cl5NO2/c7-1-2(8)4(10)6(12(13)14)5(11)3(1)9
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分类

  • {SNA} All alphab
  • {SA} Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Aromatics, Chromatography, EPA, Endocrine Disruptors (Draft), Environmental Standards, Fungicides, Method Specific, Pesticides, Pesticides & Metabolites, Q, Q-Z
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Antibiotics and Antimycotics, Antimycotics, Molecular Biology, Plant Biotechnology, Plant Tissue Culture
  • {SNA} Ad
  • {SNA} Additional Standards, All Fungicides, Analytical Standards, Aromatics, EPA, Endocrine Di

产品应用

  • 应用于抗生素的选择应用，溶解度，溶液稳定性等研究

相关文献及参考

  • Short: III/20a
  • Merck 14 ,8080
  • Merck: 14,8080
  • Merck: 14,8080 Beilstein: 5,247
  • Short: IV/8A
  • Alborch L, Bragulat MR, Cabañes FJ., Comparison of two selective culture media for the detection of Fusarium infection in conventional and transgenic maize kernels. Lett. Appl. Microbiol. 50 , 270-275, (2010) 摘要
  • Falcão VC, Ono MA, et. al., Fusarium verticillioides: evaluation of fumonisin production and effect of fungicides on in vitro inhibition of mycelial growth. Mycopathologia 171 , 77-84, (2011) 摘要

安全信息

GHS Symbol
WGK Germany2
Hazard Codes Xi,N Xi;N Xi,N,T,F,Xn
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSDA6650000
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Warning
Safety Statements
  • S13 Keep away from food, drink and animal foodstuffs 远离食品、饮料和动物饲料保存；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R50/53
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R11 Highly flammable 非常易燃
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number UN 3077 9/PG 3 2588/3077
Storage condition APPROX 4°C 室温、干燥、密封保存。
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 gm/kg/77W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   42,1101,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,96,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,299,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   51,329,1982

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,96,1982

TYPE OF TEST            :

TYPE OF TEST

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/disc
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 21,319,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 5 umol/L
REFERENCE :
   PHYTAJ Phytopathology.  (American Phytopathological Soc., 3340 Pilot Knob
   Rd., St. Paul, MN 55121) V.1-    1911-  Volume(issue)/page/year: 66,217,1976

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 17 umol/L
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of D

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 40 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 147,288,1985

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 11,247,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1935 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   NTIS** National Technica

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5 gm/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   35,239,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1935 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

TYPE OF TEST

其他信息

  • 可燃性危险特性:燃烧产生有毒氮氧化物气体
  • 用途四:优良的土壤杀菌剂，用作拌种剂和土壤处理剂，用于防治棉花立枯病、猝倒病，小麦、高梁腥黑穗病，马铃薯疮痂病，甘兰根肿病，莴苣灰霉病等。喷洒可防治水稻纹枯病。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
  • 用途三:优良的土壤杀菌剂，用作拌种剂和土壤处理剂，用于防治棉花立枯病、猝倒病，小麦、高梁腥黑穗病，马铃薯疮痂病，甘兰根肿病，莴苣灰霉病等。喷洒可防治水稻纹枯病。
  • 中毒症状:无全身中毒报道，皮肤、眼结膜和呼吸道受刺激引起结膜炎和角膜炎，炎症消退较慢。
  • 灭火剂:干粉、泡沫、砂土
  • MSDS 信息:五氯硝基苯(82-68-8).msds
  • 用途一:用作拌种剂和土壤处理剂，用于防治棉花立枯病、炭疽病、小麦腥黑穗病、散黑穗病、蔬菜猝倒病、大蒜白腐病等
  • 急救治疗:对症治疗，误食立即催吐、洗胃。
  • 毒性分级:中毒
  • 注意事项:[1]大量药剂与作物幼芽接触时易产生药害。[2]拌过药的种子不能用作饲料或食用
  • Sigma Aldrich:82-68-8(sigmaaldrich)
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • color:yellow to tan
  • 方法二:以碘为催化剂、氯磺酸为溶剂，将2,4,5-三氯硝基苯与氯气在80-85℃反应。溶剂氯磺酸的用量为三氯硝基苯重量的1-3倍，碘用量为三氯硝基苯重量的0.2-0.3%，通氯至过量1%。然后冷至30℃，滤出五氯硝基苯，用80-90℃热水洗至中性，70℃下干燥，可得含量98-99%的产品，收率94%。而2,4,5-三氯硝基苯是由1,2,4三氯苯硝化得到的。上述方法耗用碘和氯磺酸，设备易腐蚀，另一种生产方法是采用由六六六无毒体得到的三氯苯埋接硝化、氯化，可得到氯硝基苯含量大于70%的原粉。原料消耗定额：三氯苯（98%）880kg/t、液氯930kg/t、硫酸（折100%）1020kg/t、硝酸（98%）350kg/t、氯磺酸（90%以上）1100kg/t。
  • 急性毒性:口服- 大鼠 LD50: 1100 毫克/ 公斤; 口服- 小鼠 LD50: 1400 毫克/ 公斤
  • 职业标准:TLV-TWA 0.5 毫克/ 立方米
  • 几乎不溶于水、冷乙醇，易溶于二硫化碳、苯、氯仿。化学性质稳定，不易挥发，不易水解和氧化，不受日光、温度和酸碱度影响，土壤中残效较长。
  • 上游原料:硝基苯 --> 原粉 --> 2,4,5-三氯硝基苯
  • 图谱信息:五氯硝基苯(82-68-8)红外图谱(IR2) 五氯硝基苯(82-68-8)红外图谱(IR3) 五氯硝基苯(82-68-8)核磁图( 13 CNMR) 五氯硝基苯(82-68-8)质谱(MS) 五氯硝基苯(82-68-8)Raman光谱 五氯硝基苯(82-68-8)红外图谱(IR1)
  • 用途二:保护性杀菌剂，低毒，无内吸作用。用于种子清毒和土壤处理，其杀菌机制是影响菌丝细胞的有丝分裂。防治小麦腥黑穗病、散黑穗病，用40%粉剂500g拌种100kg；防治棉花苗期病害用40%粉剂1000g拌种100kg；防治油菜菌核病，每百平方米用40%粉剂65.6g拌细土1.5～3kg，在发病初期撒于根部附近；防治马铃薯疮痂病，每百平方米用50%可湿性粉剂375～675g，条施于播种沟内。
  • 方法一:1，2，4-三氯苯经硝化，得三氯硝基苯。再以氯磺酸为溶剂，碘为催化剂，于80～85℃通氯，氯化后制得五氯硝基苯。
  • 外观性质:无色或微黄色结晶，有发霉的气味。
  • 毒性:大鼠急性经口 LD 50 >12000mg/kg，原药对大鼠急性经口 LD 50 1700mg/kg，家兔急性经皮 LD 50 >4000mg/kg。动物试验未见致癌、致畸、致突变现象。鲤鱼 LC 50 为10～40mg/L (48h)。
  • MOL 文件:82-68-8.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Nitro Compounds 硝基化合物
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PA - PEN - P
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Alpha sort - Pesticides & Metabolites
  7. Q-Z - Alpha sort
  1. Life Science 生命科学
  2. Plant Biotechnology 植物生物技术
  3. Plant Tissue Culture - Plant Biotechnology
  4. Antibiotics and Antimycotics - Plant Tissue Culture
  5. Antimycotics - Antibiotics and Antimycotics

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