4-Acetamidobenzene-1-sulfonyl chloride 对乙酰胺基苯磺酰氯
CAS 121-60-8 MFCD00007442
化学结构图
SMILES: CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1
化学属性
| Mol. Formula | C8H8ClNO3S |
|---|---|
| Mol. Weight | 234 |
| Density | 1.422 |
| Melting Point | 142-145 °C (dec.)(lit.) |
| TSCA | Yes |
| Solubility | 略溶于水 |
| Appearance | 对乙酰胺基苯磺酰氯(121-60-8)为浅褐色针状（从苯中）或棱柱状（从苯和氯仿中）结晶。熔点149℃（分解）。溶于苯，乙醚，氯仿和二氯乙烷。在空气中易吸潮分解。有轻微乙酸气味。 |
别名和识别编码
| Chemical Name | 4-Acetamidobenzene-1-sulfonyl chloride |
|---|---|
| CAS Number | 121-60-8 |
| Synonym | NASC 4-(Acetylamino)benzene-2,3,5,6-sulfonyl Chloride 4’-(chlorosulfonyl)acetanilide ASC 4-乙酰胺基苯磺酰氯, 98+% 氯化-N-乙酰基对氨基苯磺酰 N-Acetylsulfanilyl chloride p-(Chlorosulfonyl)acetanilide P-ACETAMINOBENZENESULFONYL CHLORIDE Dagenan chloride p-Acetamidophenylsulfonyl chloride Dagenan Chloride N-ACETYLSULFANILYL CHLORIDE 4-ACETAMIDOBENZENESULFONYL CHLORIDE 4'-(Chlorosulfonyl)acetanilide N-ACETYLSULPHANILYL CHLORIDE 对乙酰氨基苯磺酰氯 NSC 127860 N-Acetylsulfanilyl Chloride 4-Chlorosulfonylacetanilide 4-乙酰氨基苯磺酰氯 N(sup 4)-Acetylsulfanilyl chloride 4-Acetamidophenylsulfonyl chloride 4-Acetamidobenzenesulfonyl chloride; ASC {Chemicalbook |
| EC Number | 204-485-1 |
| Beilstein Registry Number | 14(3)2043 |
| MDL Number | MFCD00007442 |
| Merck Number | 103 |
| PubChem Substance ID | 87561773 |
| Reaxys-RN | 746676 |
| Chemical Name Translation | 对乙酰胺基苯磺酰氯 |
| LabNetwork Molecule ID | LN00221914 |
| InChI | InChI=1S/C8H8ClNO3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11) |
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分类
- Sulfur & Selenium Compounds
- Sulfonyl Chlorides
- Aromatics
- Amines
- {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonyl Halides, Sulfur Compounds
产品应用
- A sulfanilamide derivative of Chitosan
相关文献及参考
- Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008),
- Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009),
安全信息
GHS Symbol
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R37 Irritating to respiratory system 刺激呼吸道
- R34 Causes burns 会导致灼伤
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331+P310
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
- P405 Store locked up. 上锁保管。
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3200 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Behavioral - ataxia REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
其他信息
- 急性毒性:口服-大鼠LD50:>;2300毫克/公斤;口服-小鼠 LD50: 1600 毫克/公斤
- 毒性分级:中毒
- 可燃性危险特性:可燃;加热分解释放极毒氮氧化物, 硫氧化物和氯化物烟雾
- 类别:有毒物品
- 用途二:多种磺胺药物的中间体，如磺胺噻唑，磺胺异噁唑，磺胺甲基异噁唑，磺胺苯吡唑，磺胺二甲异嘧啶等。也是染料的中间体。
- TCI Shanghai:对乙酰氨基苯磺酰氯 4-Acetamidobenzenesulfonyl Chloride,>;97.0%(T)(121-60-8)
- 对乙酰胺基苯磺酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0074 4-乙酰氨基苯磺酰氯 4-Acetamidobenzenesulfonyl Chloride 25G 163元 2014/06/02 A0074 4-乙酰氨基苯磺酰氯 4-Acetamidobenzenesulfonyl Chloride 500G 831元 2010/06/21 150725000 对乙酰胺基苯磺酰氯 N-Acetylsulfanilyl chloride 99% 500 GR 527元
- 下游产品:(1R,2R)-N-BOC-1-氨基-2-苯基环丙羧酸 --> 磺胺 --> 磺胺甲恶唑 --> 荧光增白剂 NR,赫司特鲁克斯 --> 4-(吗啉磺酰)苯胺 --> 对乙酰氨基苯亚磺酸
- 灭火剂:干粉、泡沫、砂土和水
- MOL 文件:121-60-8.mol
- 方法一:乙酰苯胺氯磺化下面是两个工业操作示例。操作示例1 搅拌下将67.5kg乙酰胺基苯加到290kg氯磺酸中，控制加料温度在15℃以下,加毕渐升温至60℃，保温搅拌2h，然后将反应物逐渐加于冰水中稀释，温度保持10℃以下，过滤，用冰水漂洗至刚果红试纸呈中性。得对乙酰氨基苯磺酰氯。操作示例2 在20℃ 以下将乙酰胺基苯均匀加入氯磺酸中，按重量计,乙酰苯胺：氯磺酸＝1:5.26，在50± 2℃反应3h。放置8h后，约20℃以下，加适量水分解过剩的氯磺酸，温度不超过28℃，稍冷，过滤，洗涤滤饼至pH=3-4，得对乙酰氨基磺酰氯。收率为83%。该品不宜久存，作为医药和染料生产的中间产物，含量为30%。
- Acros Organics:4-乙酰氨基苯磺酰氯 N-Acetylsulfanilyl chloride, 99%(121-60-8)
- 储运特性:库房通风低温干燥
- 图谱信息:对乙酰胺基苯磺酰氯(121-60-8)红外图谱(IR1) 对乙酰胺基苯磺酰氯(121-60-8)红外图谱(IR2)
- MSDS 信息:4-Acetamidobenzenesulfonyl chloride(121-60-8).msds
- Alfa Aesar:4-乙酰胺基苯磺酰氯,98+% 4-Acetamidobenzenesulfonyl chloride, 98+%(121-60-8)
- Sigma Aldrich:121-60-8(sigmaaldrich)
- F:9-21
- 用途一:用于制备磺胺间二甲氧嘧啶、磺胺甲基异恶唑等磺胺类药
- 海关编码:29242995
- 敏感性:Moisture Sensitive
- 上游原料:氨基苯 --> 氯磺酸 --> 乙酰胺 --> 刚果红试纸 --> 氨基磺
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