Methanesulfonic Anhydride 甲烷磺酸酐

CAS 7143-01-3 MFCD00007556

化学结构图

7143-01-3
SMILES: CS(=O)(=O)OS(C)(=O)=O

化学属性

Mol. FormulaC2H6O5S2
Mol. Weight174.20
Boiling Point125°C at 4 mmHg
Melting Point64-67°C
TSCAYes
Density1.583
Vapor Density3.3 (vs air)
Flash Point128.7±18.7 °C
Appearance 白色棱状结晶。熔点71℃，沸点138℃（1.33kPa），溶于氯仿、苯、热乙醚。
Stability易吸潮

别名和识别编码

Chemical NameMethanesulfonic Anhydride
CAS Number7143-01-3
PubChem Substance ID81560
EC Number230-442-1
Beilstein Registry Number972316
MDL NumberMFCD00007556
Synonym Methanesulfonic anhydride {LY} Methanesulfonic anhydride {} {LY} Methanesulfonic anhydride {} {} {LY} Methanesulfonic anhydride {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methanesulfonic anhydride {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation甲烷磺酸酐
InChIKeyIZDROVVXIHRYMH-UHFFFAOYSA-N
LabNetwork Molecule IDLN00224858
InChIInChI=1S/C2H6O5S2/c1-8(3,4)7-9(2,5)6/h1-2H3
Canonical SMILESCS(OS(C)(=O)=O)(=O)=O
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分类

  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonic/Sulfinic Acid Anhydrides, Sulfur Compounds
  • {SA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonic/Sulfinic Acid Anhydrides, Sulfur Compounds

产品应用

  • May be used to generate mesylates (methanesulfonyl esters).

相关文献及参考

  • Primary and secondary alcohols may be oxidized to carbonyl compounds by sulfonic anhydrides in DMSO: J. Org. Chem., 39, 1977 (1974). For related methods, see Dimethyl­ sulfoxide, A13280.
  • Beilstein: 4,IV,28
  • More powerful sulfonylating reagent than the sulfonyl chloride, also avoiding possible displacement of sulfonate by halide. With a catalytic amount of the acid effects mesylation of deactivated aromatics such as 1,3-dichlorobenzene: Chem. Lett., 395 (1988); mesyl chloride is ineffective.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 8 C
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Signal word Danger
Safety Statements
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
UN Number 3261 UN 3261 8/PG 2
Risk Statements
  • R14 Reacts violently with water 遇水会猛烈反应
  • R34 Causes burns 会导致灼伤
  • R35 Causes severe burns 会导致严重灼伤
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Moisture Sensitive {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage,
Packing GroupII
Hazard Class8

其他信息

  • MOL 文件:7143-01-3.mol
  • 用途一:用于有机合成
  • 下游产品:1-BOC-3-羟甲基哌嗪 --> 4-溴-7-氮杂吲哚 --> 多非利特 --> 甲酚红
  • Alfa Aesar:甲磺酸酐,98% Methanesulfonic anhydride, 98%(7143-01-3)
  • Methanesulfonic anhydride is the acid anhydride of methanesulfonic acid. Like methanesulfonyl chloride, it may be used to generate mesylates (methanesulfonyl esters).
  • F:3-10
  • 敏感性:Moisture Sensitive
  • 甲基磺酸酐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 348761000 甲基磺酸酐 Methanesulfonic anhydride 97% 100 GR 2433元 2010/06/21 348760250 甲基磺酸酐 Methanesulfonic anhydride 97% 25 GR 745元 2010/06/21 348760050 甲基磺酸酐 Methanesulfonic anhydride 97% 5 GR 257元
  • 蒸气密度:3.3 (vs air)
  • Sigma Aldrich:7143-01-3(sigmaaldrich)
  • Acros Organics:甲烷磺酸酐 Methanesulfonic anhydride(7143-01-3)
  • 海关编码:29041000
  • MSDS 信息:Methanesulfonic anhydride (7143-01-3).msds
  • 图谱信息:甲基磺酸酐(7143-01-3)核磁图( 13 CNMR) 甲基磺酸酐(7143-01-3)核磁图( 1 HNMR) 甲基磺酸酐(7143-01-3)红外图谱(IR1) 甲基磺酸酐(7143-01-3)质谱(MS) 甲基磺酸酐(7143-01-3)红外图谱(IR2)
  • 上游原料:甲基磺酸 --> 青石棉,钠闪石
  • 方法一:将300g五氧化二磷与90g硅藻土混合，取其一半，在搅拌下加入305g甲基磺酸和10g石棉的混合物中，当反应趋缓时在80℃加热2.5h，然后将另一半五氧化二磷硅藻土分次加入，再加热3h。反应混合物用二氯甲烷提取，蒸除溶剂，减压蒸馏，收集105-109℃（0.133kPa）馏分，得193g粗品，经乙醚-苯重结晶，得143g甲磺酸酐成品。收率55%。
  • 溶于氯仿、苯、热乙醚。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonic/Sulfinic Acids 磺酸/亚磺酸
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonic/Sulfinic Acid Anhydrides - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonic/Sulfinic Acid Anhydrides - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfones