alpha-Lobeline hydrochloride 白消安

CAS 55-98-1 MFCD00007562

化学结构图

55-98-1
SMILES: CS(=O)(=O)OCCCCOS(C)(=O)=O

化学属性

Mol. FormulaC6H14O6S2
Mol. Weight246
Melting Point114.0 to 118.0 deg-C
SolubilityDecomposes

别名和识别编码

Chemical Namealpha-Lobeline hydrochloride
Synonym 1,4-Bis(methane-sulponyloxy)butane 1,4-Dimethylsulfonoxybutane 1,4-bis(methanesulfonoxy)butane 1,4-dimesyloxybutane 1,4-dimethanesulfonoxybutane 1,4-dimethanesulphonyloxybutane 1,4-dimethylsulfonyloxybutane 1,4-丁二醇二甲烷磺酸盐 1,4-丁二醇二甲烷磺酸盐 白消安 1,4-丁二醇二甲烷磺酸盐;二甲磺酸-1,4-丁二醇;二甲磺酸丁酯; 1,4-Butanediol dimethyl sulfonate Busulfan Busulfan Wellcome Busulfex Busulphan Glyzophrol Mabli Mielosan Milecitan Miler Myeloleukon Myelosan Mylecytan Myleran Myléran Tetramethylene bis(methanesulfonate) Tetramethylenester kyseliny methansulfonove Wellcome, Busulfan X 149 busulfex n-Butane-1,3-di(methylsulfonate)
Beilstein Registry Number1791786
PubChem Substance ID2478
CAS Number55-98-1
EC Number200-250-2
MDL NumberMFCD00007562
Chemical Name Translation白消安
Reaxys-RN1791786
Merck Number1505
Wiswesser Line NotationWS1&O4OSW1
LabNetwork Molecule IDLN00239479
InChIInChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
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分类

  • {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, B, BI - BZ, Chromatography, Drugs & Metabolites, Environmental Standards, Forensic an
  • {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography,
  • {SNA} Additional Standards, Analytical Standards, Chromatography,

相关文献及参考

  • Merck 14 ,1505
  • Beil. 4 ,IV,19
  • Corp MSDS 1 (1), 596:D / FT-NMR 1 (1), 1441:C / IR-Spectra (3), 541:B / IR-Spectra (2), 478:G / NMR-Reference 2 (2), 801:B / RegBook 1 (1), 1069:C / Sax 6 , 547 / Structure Index 1 , 166:B:4

安全信息

Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P310+P330
  • P301+P316
  • P302+P350
  • P302+P352
  • P302+P352+P312+P361+P364
  • P304+P340
  • P304+P340+P311
  • P305+P351+P338
  • P308+P313
  • P308+P316
  • P309+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P316
  • P318
  • P319
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSEK1750000
GHS Symbol
Signal word
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311+H331
  • H310 Fatal in contact with skin 皮肤接触致命
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H350 May cause cancer 可能致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Hazard Codes T+,T T+
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R45 May cause cancer 可能致癌
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
UN Number UN 2811 6.1/PG 1 2811
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,3069,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg/42D-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - leukemia
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   25,20,1965

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1140 mg/kg/9Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 16720 ug/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   JCROD7 Journal of Cancer Research and Clinical Oncology.  (Springer-Verlag
   New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 46 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   6,160,1952

TYPE OF TEST            : LD50 - Le

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 8 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1463,1984

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - agranulocytosis
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,203,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - ra

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHABA8 Chemical Abstracts.  (Chemical Abstracts Service, Box 3012, Columbus,
   OH  43210) V.1-    1907-  Volume(issue)/page/year: 55,10679a,1961

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Implant
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 600 mg/kg
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 90 umol/L
REFERENCE :
   EVSRBT Environmental Science Research.  (Plenum Pub. Corp., 233 Spring St.,
   New York, NY 10013) V.1-    1972-  Volume(issue)/page/year: 24,175,1981

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 30 ug
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   JOGNAU Journal of Genetics.  (Belghoria, India)  V.1-63, 1910-77.
   Discontinued.  Volume(issue)/page/year: 54,146,1956

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Human - woman
DOSE/DURATION           : 138 mg/kg
REFERENCE :
   GRM

TYPE OF TEST            : Heritable translocation test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 ppb
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 5280 ug/kg
SEX/DURATION            : female 14-26 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 92,580,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 17 mg/kg
SEX/DURATION            : female 4-36 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 25,85,1960

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 30(1),14A,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 40 mg/kg
SEX/DURATION            : mal

其他信息

  • MOL 文件:55-98-1.mol
  • 类别:有毒物质
  • 可燃性危险特性:热分解排出有毒硫氧化物烟雾
  • 上游原料:甲基磺酰氯 --> 1,4-丁二醇
  • 白消安价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B1022 1,4-丁二醇二甲烷磺酸盐 1,4-Butanediol Dimethanesulfonate 25G 630元 2010/06/21 306520250 白消安 Busulfan 98% 25 GR 686元
  • 方法一:由甲基磺酰氯与1,4-丁二醇缩合而得。
  • 毒性分级:高毒
  • Sigma Aldrich:55-98-1(sigmaaldrich)
  • 外观性质:白色结晶。
  • 急性毒性:腹腔-大鼠 LD50: 22 毫克/公斤; 口服-小鼠 LD50: 110 毫克/公斤
  • 灭火剂:水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • MSDS 信息:1,4-双甲基磺氧基丁烷(55-98-1).msds
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放; 不易久储, 以防聚合
  • Acros Organics:白消安 Busulfan, 98%(55-98-1)
  • TCI Shanghai:二甲磺酸-1,4-丁二醇 1,4-Butanediol Dimethanesulfonate,>;97.0%(T)(55-98-1)
  • 用途一:抗肿瘤药。该品为细胞周期非特异性药物,主要用于G1期和M期。该品低剂量抑制骨髓粒细胞的生成,对红细胞和淋巴细胞几乎无影响。大剂量时对红细胞和淋巴细胞几乎无影响。大剂量时对红细胞和淋巴细胞的生成起抑制作用。由于选择性作用,对慢性粒细胞白血病疗效显著。白消安为目前治疗慢性粒细胞白血病的主要药物,其缓解率可达80-90%。但一旦发生急性变时应停药。

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