Methylhydrazine (剧毒品，不能销售)甲基肼

CAS 60-34-4 MFCD00007621

化学结构图

60-34-4
SMILES: CNN

化学属性

Mol. FormulaCH6N2
Mol. Weight46.09
Refractive indexn20/D 1.4325(lit.)
Boiling Point88-90 °C(lit.)
Density0.875 g/mL at 20 °C(lit.)
Autoignition Point385 °F
Vapor Density1.6 (vs air)
Vapor Pressure37.5 mmHg ( 20 °C)
Flash Point21 ºC
Melting Point-21 ºC
Solubility可溶

别名和识别编码

Chemical NameMethylhydrazine
Synonym metylohydrazyna(polish) MONOMETHYL HYDRAZINE 甲肼 Rcra waste number P068 Hydrazinomethane 甲基肼 CH3NHNH2 甲基联胺 N-METHYLHYDRAZINE Metylohydrazyna 一甲肼 rcrawastenumberp068 1-methylhydrazine methyl-hydrazine hydrazinomethane Monomethyl hydrazine (MMH) Methylydrazine MethylHydrazine40% 1-Methylhydrazine 1-Methylhydrazine; Hydrazomethane methyl-hydrazin hydrazine, methyl- Methylhydrazine methyl hydrazine 2-Methylhydrazine METHYLHYDRAZINE (controlled chemical) RCRA waste number P068 HydraZine,methyl- methylhydrazine Monomethylhydrazine monomethylhydrazine N-Methylhydrazin MMH Hydrazomethane
CAS Number60-34-4
PubChem Substance ID6061
EC Number200-471-4
Beilstein Registry Number0635645
MDL NumberMFCD00007621
Chemical Name Translation(剧毒品，不能销售)甲基肼
Merck Number13,6109
Wiswesser Line NotationZM1
InChIInChI=1S/CH6N2/c1-3-2/h3H,2H2,1H3
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分类

  • Building Blocks, Chemical Synthesis, Hydrazines, Nitrogen Compounds, Organic Building Blocks
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Hydrazines, Nitrogen Compounds, Organic Building Blocks
  • {Chemicalbook} 农药中间体: 除草剂中间体: 磺酰脲类除草剂

相关文献及参考

  • Merck 14 ,6086
  • Beil. 4 ,IV,3322
  • Fieser 4 ,340
  • Aldrich MSDS 1 , 1259:A / Corp MSDS 1 (2), 2364:C / FT-IR 2 (1), 442:D / FT-IR 1 (1), 279:C / FT-NMR 1 (1), 449:A / IR-Spectra (2), 153:G / IR-Spectra (3), 165:B / NMR-Reference 2 (1), 237:C / RegBook 1 (1), 301:E / Sax 6 , 1858 / Sigma FT-IR 1 (2), 734:A / Structure Index 1 , 41:D:1 / Vapor Phase 3 , 364:A
  • Short: II/19b Title: Molecular Constants: Rotational, Centrifugal Distortion and Related Constants of Diamagnetic Asymmetric Top Molecules Author: Demaison, J.; Hüttner, W.; Vogt, J.; Wlodarczak, G. Editor: Hüttner, W. Source: Landolt-Börnstein, New Series Volume: II/19b Year: 1992 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-54578-6 ISBN: 978-3-540-54578-1 Internet Resource: DOI:10.1007/b44334 RefComment: XI, 488 pages. Abstract: Volume II/19 Molecular Constants mostly from Microwave, Molecular Beam and Sub-Doppler Laser Spectroscopy is a supplement to the earlier volumes II/4, II/6, and II/14. The slight change in the title reflects current trends in the applications of spectroscopic methods. Together, the four volumes collect all the critically evaluated data published up to 1989/90 on constants of free molecules obtained by classical and modern spectroscopy. Volume II/19 is divided into four parts to record the growing number of investigations, especially in the microwave and millimeter wave regions, where modern techniques like Fourier Transform Microwave Spectroscopy have made new objects of interest such as molecular complexes and clusters accessible to study. Subvolume II/19b contains corresponding data on diamagnetic asymmetric top molecules.
  • Short: II/19c Title: Molecular Constants: Dipole Moments, Quadrupole Coupling Constants, Hindered Rotation and Magnetic Constants of Diamagnetic Molecules Author: Demaison,

安全信息

GHS Symbol
WGK Germany3
Hazard Codes F,T+,N F,T+,N,T F;T
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H351 Suspected of causing cancer 怀疑致癌
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H300+H330
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSMV5600000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
  • R51/53
  • R34 Causes burns 会导致灼伤
  • R26 Very toxic by inhalation 吸入极毒
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number 1244 UN 1244 6.1/PG 1
Packing GroupI
Hazard Class6.1(a)
Storage condition Flammables area
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   42,337,1969

{

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 5 ppm/6H/1Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Endocrine - adrenal cortex hyperplasia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 5 ppm/6H/1Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Endocrine - adrenal cortex hyperplasia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A154-659

TYPE OF TEST            :

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 ppm/6H/1Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse f

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 131,226,1969

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 96 ppm/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   31,667,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A125-539

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   30,429,1974

TYPE O

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 116 pmol
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A092-249

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 umol/L
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A075-605

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1075 mg/kg/5D (Intermittent)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: A

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Lung
DOSE/DURATION           : 1 umol/L
REFERENCE :
   NTIS** National Technic

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 581 umol/L
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,243,1981

TYPE OF T

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 uL/plate
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A041-973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 24 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   FACOEB Food Additives and Contaminants.  (Taylor & Francis Inc., 242 Cherry
   St., Philadelphia, PA 19106)  V.1-    1984-  Volume(issue)/page/year:
   10,391,1993

TYPE OF TEST            : TDLo - Lowest published toxic

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 33600 ug/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   FACOEB Food Additives and Contaminants.  (Taylor & Francis Inc., 242 Cherry
   St., Philadelphia, PA 19106)  V.1-    1984-  Volume(issue)/page/year:
   10,391,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   APTOD9 Abstracts of Papers, Society of Toxicology.  Annual Meetings.
   (Academic Press, Inc., 1 E. First

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        :

其他信息

  • 方法二:以水合肼、苯甲醛为原料，经缩合、甲基化反应而得。将39%的水合肼加入反应锅内，于20-30℃搅拌滴加苯甲醛，约7h加完，继续搅拌2h，放置过夜。次日过滤，用水洗涤至近中性，烘干得粒状固体苄叉连氮，熔点90-93℃，收率约95%以上。将苯、苄叉连氮、硫酸二甲酯加入反应锅内，密闭搅拌回流5h。冷却，析出固体，加水，固体即溶解，分层，进行水蒸气蒸馏，至蒸不出苯甲醛为止。加入无水乙醇，析出固体，冷却，过滤，得硫酸甲肼。收率为60%-70%。
  • 毒性分级:剧毒
  • {Che
  • 方法一:其制备方法是用甲胺与氯胺(NH 2 Cl)反应而得到产品。 CH 3 NH 2 +NH 2 Cl→CH 3 NHNH 2
  • {Chemic
  • 图谱信息:甲基肼(60-34-4)质谱(MS) 甲基肼(60-34-4)红外图谱(IR1) 甲基肼(60-34-4)核磁图( 1 HNMR) 甲基肼(60-34-4)核磁图( 13 CNMR)
  • MSDS 信息:甲基肼(60-34-4).msds
  • 刺激数据:有腐蚀性
  • 甲基肼价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 126955000 甲基肼 Methylhydrazine 98% 500 ML 3741元 2010/06/21 126951000 甲基肼 Methylhydrazine 98% 100 ML 1122元 2010/06/21 126950100 甲基肼 Methylhydrazine 98% 10 ML 459
  • 上游原料:氢氧化钠 --> 氨 --> 氯 --> 硫酸二甲酯 --> 一甲胺 --> 氯胺 T --> 甲基肼硫酸盐 --> 苄连氮 --> 苯苄
  • 用途一:甲基肼是除草剂吡嘧磺隆，杀螨剂唑螨酯、吡螨胺的中间体。
  • 下游产品:1-甲基-5-三氟甲基-1H-吡唑-4-胺 --> 1-甲基-3-三氟甲基-1H-吡唑 --> 4-氯-1,3-二甲基-1H-吡唑3,4-吡啶-5-羧酸 --> 1-甲基-3-苯基-1H-吡唑-5-甲醛 --> 1-甲基-3-正丙基-吡唑-5-甲酸乙酯 --> 1-甲基-3-三氟甲基-4-溴-1H-吡唑 --> 盐酸甲基苄肼 --> 1-甲基-5-三氟甲基-1H-吡唑-4-醛 --> 1,5-二甲基-1H-吡唑-3-羰酰氯 --> 安替比林 --> 4-溴-1,3,5-三甲基吡唑 --> 1-甲基-5-三氟甲基-1H-吡唑-4-羧酸 --> 1,3,5-三甲基吡唑 --> 1-甲基-4-硝基-3-丙基-1H-吡唑-5-羧酸 --> 1-甲基-5-三氟甲基-1H-吡唑-4-腈 --> (1-甲基-5-三氟甲基-1H-吡唑-4-基)甲胺 --> 1-甲基-5-三氟甲基-1H-吡唑-4-酰氯 --> 1,5-二甲基-1H-吡唑-3-甲酸 --> 1-甲基-5-丙基-1H-吡唑-3-酰胺 --> 1-甲基-3-丙基-1H-吡唑-5-酰胺 --> 1-甲基-3-丙基-1H-吡唑-5-酰肼 --> 1-甲基-5-三氟甲基-1H-吡唑 --> (1-甲基-5-三氟甲基-1H-吡唑-4-基)甲醇 --> 1-甲基-5-三氟甲基-1H-吡唑-4-酰胺 --> 四唑嘧磺隆 --> 1,3-二甲基-1H-噻吩基[2,3-c!吡唑-5-羧酸 --> 3-乙基-1-甲基-1H-吡唑-5-甲酸乙酯 --> 1,4,6-三甲基-3-氨基吡唑并[3,4-B]吡啶 --> 5-氯-1,3-二甲基-1H-吡唑-4-甲醛 --> 2,2,2-三氟-1-(1-甲基-3-三氟甲基-1H-吡唑-4-基)乙酮 --> 3-羟基-1-甲基-5-三氟甲基-1H-吡唑 --> 1,3-二甲基-5-羟基吡唑 --> 1-甲基-3-氨基-吡唑并[3,4-B]吡啶 --> 1-甲基-5-氨基吡唑-4-羧酸乙酯
  • {Chemica
  • Acros Organics:甲基肼 Methylhydrazine, 98%(60-34-4)
  • 灭火剂:雾状水、砂土
  • 职业标准:TWA 0.35 毫克/立方米
  • 方法一:其制备方法是用甲胺与氯胺(NH 2 Cl)反应而得到产品。 CH 3 NH 2 +NH 2 Cl→CH 3 NHNH 2 +HCl

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Hydrazines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines

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