2-Nitroaniline 2-硝基苯胺

CAS 88-74-4 MFCD00007687

化学结构图

88-74-4
SMILES: Nc1ccccc1[N+](=O)[O-]

化学属性

Mol. FormulaC6H6N2O2
Mol. Weight138
Boiling Point165°C/28mmHg(lit.)
Melting Point72.0 to 74.0 deg-C
Density1.442
Flash Point168°(334°F)
TSCAYes
Solubility1.1 G/L (20 ºC)
Stability对光敏感

别名和识别编码

Chemical Name2-Nitroaniline
CAS Number88-74-4
PubChem Substance ID87573506
EC Number201-855-4
Beilstein Registry Number12,687
MDL NumberMFCD00007687
Merck Number6582
Synonym Azoic Diazo Component 6 C.I. 37025 o-Nitrobenzenamine 2-nitro-Benzenamine Fast Orange Base JR ONA 2-Nitro-benzeneamine 2-nitro-aniline Hiltonil Fast Orange GR Base O-NITRANILINE Azogene Fast Orange GR 2-Nitrophenylamine 2-Nitro 2-nitroaniline aniline,o-nitro- 1-Amino-2-nitrobenzene 2-硝基苯胺 Orange Base IRGA II benzenamine, 2-nitro- Fast Orange O Base C.I. Azoic Diazo Component 6 o-Nitraniline {uni_ha 1-Nitro-2-aminobenzene Fast Orange Base GR Orange Salt Irga II ORTHO-NITR Fast Orange Salt JR Azoene Fast Orange GR Base 2-Nitroaniline Orange GRS Salt {u {C aniline, o-nitro- Fast Orange GR Base 2-nitrobenzenamine {uni_hambur Fast Orange Salt GR o-Aminonitrobenzene {Chemicalb o-Nitroanilin (a- Phase) {un Orange Base Irga II {Che {uni_h 2-Nitro-phenylamine 1-amino-2-nitro-benzen 2-Nitrobenzenamine o-Nitroanilin (γ- Phase Azoene Fast Orange GR Salt 2-硝基苯胺; 邻硝基苯胺; 1-氨基-2-硝基苯 O-NITROANILINE o-nitroaniline Azofix Orange GR Salt o-Nitraniline 2-aminonitrobenzene Fast Orange O Salt o-Nitroanilin (ß- Phase) 邻硝基苯胺 Orange Base Ciba II Hiltosal Fast Orange GR Salt LABO o-Nitroanilin (β- Phase) ortho-nitroaniline
Chemical Name Translation2-硝基苯胺
Wiswesser Line NotationZR BNW
LabNetwork Molecule IDLN00227220
Reaxys-RN509275
InChIInChI=1S/C6H6N2O2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H,7H2
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分类

  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 苯并咪唑类杀菌剂
  • {SNA} Amines, Building Blocks, C6, Chemical Synthesis, NLO Chromophores and Intermediates, Nitrogen Compounds, Non-Linear Optical (NLO) Materials, Organic Building Blocks, Organic and Printed Electronics, Photonic and Optical Materials, 材料科学
  • {SNA} Analytical Reagents,
  • Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, Environmental Standards, N, N-O, NA - NI, Volatiles/ Semivolatiles
  • {SNA} Amines,
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • 本品测定微量碘化物，是重要的有机合成中间体。

相关文献及参考

  • Short: II/27B
  • Merck: 14,6583 Beilstein: 12,IV,1563
  • Short: II/27C
  • Merck: 14,6583

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311+H331
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
  • H370 Causes damage to organs 导致器官损伤
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T T,F F,T
RTECSBY6650000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P312+P361+P364
  • P304+P340+P311
  • P305+P351+P338+P337+P313
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
UN Number 1661 UN 1661 6.1/PG 2 UN1661
Risk Statements
  • R52/53
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
  • R11 Highly flammable 非常易燃
Packing GroupII
Storage condition 密封避光保存。 2-8°C
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,91,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2350 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   VKMGA7 Voprosy Kommunal'noi Gigieny.  Problems of Communal Hygiene.  (Kiev,
   USSR)  V.6, 1966. For publisher information, see GNAMAP.
   Volume(issue)/page/year: 6,89,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 9441 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issu

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 170,11,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 320,273,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 44,9,1977

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 15500 ng/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 738 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 320,273,1994

Restrict 危险品

其他信息

  • 用途一:用作染料中间体和照相防灰剂原料，亦可用于农药多菌灵的生产
  • 方法二:将邻硝基氯苯加入盛有一定浓度氨水的高压釜中，于185-190℃、4-4.5MPa下，进行氨解，生成邻硝基苯胺粗品再经冷却、结晶、过滤，即得成品。原料消耗定额：邻硝基氯苯1156kg/t、液氨648kg/t。
  • MO
  • 毒性分级:中毒
  • 方法一:其制备方法是由邻氯硝基苯经氨解而得，工艺为在14.7 MPa压力和230℃温度下于高压管道反应器内连续进行，当邻氯硝基苯和氨进入反应管道，停留20min，经气动薄膜调节阀一次降压至98kPa压力，然后进入膨胀槽蒸发脱氨，蒸发出来的氨经喷射泵进入吸氨排管进行循环吸收，补加部分液氨后继续供氨解用，脱氨的物料经后处理即得产品。
  • 与无机酸生成水溶性盐。溶于热水、醇和氯仿，微溶于冷水。低毒，半数致死量(大鼠，经口)1600mg/kg。有刺激性。
  • 职业标准:STEL 0.5 毫克/立方米
  • 检测方法:GC,NMR
  • Acros Organics:2-硝基苯胺 2-Nitroaniline, 98%(88-74-4)
  • 类别:有毒物品
  • Alfa Aesar:2-硝基苯胺,98% 2-Nitroaniline, 98%(88-74-4)
  • 用途二:邻硝基苯胺是杀菌剂多菌灵、苯菌灵、甲基硫菌灵、噻菌灵和杀虫剂喹硫磷的中间体。
  • MSDS 信息:邻硝基苯胺(88-74-4).msds
  • 可燃性危险特性:明火可燃; 燃烧产生有毒氮氧化物烟雾
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类、食品添加剂分开存放
  • Sigma Aldrich:88-74-4(sigmaaldrich)
  • 海关编码:29214210
  • 下游产品:1,2-苯二胺 --> 邻氯硝基苯 --> 2-[3-(2H-苯并三唑-2-基)-4-羟基苯基]乙基 2-甲基丙烯酸酯 --> 3,5-二氯苯胺 --> 阿苯达唑 --> 吡咯咪唑 --> 4-丙硫基邻苯二胺 --> 4,7-二苯基-1,10-菲罗啉 --> 奥拉多司 --> 2-巯基苯并咪唑 --> 2-溴苯胺 --> 1,2-二硝基苯 --> 还原红 14 --> 8-硝基喹啉 --> 颜料黄 5 --> 1-溴-2-硝基苯 --> 美喹多司 --> 2-硝基-4-硫氰基苯胺 --> 分散黄119 --> 2-硝基乙酰苯胺
  • 色指数:37025
  • 图谱信息:2-硝基苯胺(88-74-4)核磁图( 1 HNMR) 2-硝基苯胺(88-74-4)核磁图( 13 CNMR) 2-硝基苯胺(88-74-4)质谱(MS) 2-硝基苯胺(88-74-4)红外图谱(IR2) 2-硝基苯胺(88-74-4)红外图谱(IR1)
  • 2-硝基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80089660 2-硝基苯胺（易制爆） 100g 37.5元 2011/08/23 80089670 2-硝基苯胺（易制爆） kg 19.8元 2010/06/21 128351000 2-硝基苯胺 2-Nitroaniline 98% 100 GR 293元
  • 用途三:该品为冰染染料色基（橙色基 GC），以及其他染料中间体，可用于手棉麻织物的染色，还可制得色淀。亦是橡胶防老剂MB、农药多菌灵、光稳定剂UV-P的中间体。
  • 上游原料:氨 --> 邻氯硝基苯
  • TCI Shanghai:2-硝基苯胺 2-Nitroaniline,>;99.0%(GC)(88-74-4)
  • 外观性质:橙黄色针状结晶。
  • F:8
  • 用途四:本品测定微量碘化物，是重要的有机合成中间体，染料中间体，是生产染料、橡胶防老剂和农药多菌灵的原料。
  • 灭火剂:雾状水、泡沫、二氧化碳、砂土
  • 急性毒性:口服

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Titration - Analytical Reagents
  4. Non-aqueous Titration Reagents - Titration
  5. Indicators for non-aqueous titration - Non-aqueous Titration Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Titration - Analytical Reagents
  4. Non-aqueous Titration Reagents - Titration
  5. Indicators for non-aqueous titration - Non-aqueous Titration Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. C6 - Amines
  1. C10 - Amines
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. N - Alphabetic
  5. NA - NI - N
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. N-O - Alpha Sort
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C11 to C38
  1. Materials Science 材料科学
  2. Organic Nonlinear Optical Materials