5-Chloro-2-hydroxyaniline 2-氨基-4-氯苯酚

CAS 95-85-2 MFCD00007694

化学结构图

95-85-2
SMILES: Nc1cc(Cl)ccc1O

化学属性

Mol. FormulaC6H6ClNO
Mol. Weight143.57
Melting Point137.0 to 141.0 deg-C
Density0.973
TSCAYes
Solubility不溶. <0.1 G/100 ML AT 20 ºC
Flash Point209 °F
Appearance 深褐色油状物。熔点30℃（29.4℃），沸点264.3℃，129.5℃（1.73kPa），115-118℃（0.67kPa），相对密度1.5187（20/4℃），折射率1.5836，闪点98℃。在空气中不稳定，吸潮易生成邻氯苯甲酸，三个氯活性强。能与其他基团缩合。不溶于水，溶于醇、苯、醚和其他有机溶剂。有刺激性气味。
Boiling Point260-264°C
Refractive index1.5836

别名和识别编码

Chemical Name5-Chloro-2-hydroxyaniline
Synonym 2-Amino-4-chlorophenol {} {SA} 5-氯-2-羟基苯胺 {} {} {Chemicalbook} 5-氯-2-羟基 {} {} {} {ALF} 5-Chloro-2-hydroxyaniline {} {} {} {} {Chemicalbook} 5-CHLORO-2-HYDROXYANILINE {} {} {} {} {} {Chemicalbook} 4-氯-2-氨基酚 {} {} {} {} {} {} {ALD} 4-氯-2-氨基苯酚, 对氯邻氨基苯酚 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 4-氯-2-氨基苯酚(4-氯-2-氨基苯酚) {} {} {} {} {} {} {} {} {Chemicalbook} 4-氯-2-氨基苯酚 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 4-Chloro-2-AMINOPHENOL (2-AMINO-4-CHLOROPHENOL) {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 4-CHLORO-2-AMINOPH {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 2-胺-4-氯苯酚 {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 2-羟基-5-氯苯胺 {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 2-氯三氯甲基苯 {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 2-氨基-4-氯酚 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {}
CAS Number95-85-2
PubChem Substance ID87561938
EC Number202-458-9
Beilstein Registry Number13,383
MDL NumberMFCD00007694
Reaxys-RN774859
Chemical Name Translation2-氨基-4-氯苯酚
Wiswesser Line NotationZR BQ EG
LabNetwork Molecule IDLN00225378
InChIInChI=1S/C6H6ClNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2
Canonical SMILESOC1=CC=C(Cl)C=C1N
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分类

  • {SA} Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols
  • Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols

产品应用

  • 氯唑沙宗的中间体。

相关文献及参考

  • Beilstein:13,383

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xn,Xi
RTECSSJ5700000
Precautionary statements
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P350
  • P337+P313
  • P308+P313
  • P302+P352+P332+P313+P362+P364
Signal word Warning
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R36 Irritating to eyes 刺激眼睛
  • R38 Irritating to skin 刺激皮肤
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number UN 3261 8/PG 2 UN 2673 6.1/PG 2 UN2673 2673
Packing GroupII
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1030 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(8),50,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 690 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(8),50,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

Restrict 危险品
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • Alfa Aesar:2-氯苯并三氯,99% 2-Chlorobenzotrichloride, 99%(2136-89-2)
  • 下游产品:邻氯苯甲醛 --> 邻氯三氟甲苯 --> 克霉唑 --> 邻氯苯基二苯基氯甲烷
  • 上游原料:氮苯 --> 4-氯-2-硝基苯酚 --> 氯偶氮苯
  • 毒性分级:中毒
  • {Chemical
  • MSDS 信息:1-Chloro-2-(trichlor
  • TCI Shanghai:2-氯三氯甲苯 2-Chlorobenzotrichloride,>;98.0%(GC)(2136-89-2)
  • 上游原料:五氯化磷 --> 对氯甲苯 --> 2-氯甲苯 --> 四氯化钛
  • 色指数:76525
  • 图谱信息:2-氯三氯甲苯(2136-89-2)质谱(MS) 2-氯三氯甲苯(2136-89-2)红外图谱(IR1) 2-氯三氯甲苯(2136-89-2)核磁图( 13 CNMR) 2-氯三氯甲苯(2136-89-2)Raman光谱 2-氯三氯甲苯(2136-89-2)核磁图( 1 HNMR)
  • 类别:有毒物品
  • 海关编码:29222900
  • 2-氯三氯甲苯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0586 2-氯三氯甲苯 2-Chlorobenzotrichloride 500G 665元 2014/06/02 C0586 2-氯三氯甲苯 2-Chlorobenzotrichloride 25G 224元 2010/05/25 B
  • MOL 文件:95-85-2.mol
  • 图谱信息:4-氯-2-氨基苯酚(95-85-2)质谱(MS) 4-氯-2-氨基苯酚(95-85-2)核磁图( 1 HNMR) 4-氯-2-氨基苯酚(95-85-2)核磁图( 13 CNMR) 4-氯-2-氨基苯酚(95-85-2)红外图谱(IR2) 4-氯-2-氨基苯酚(95-85-2)红外图谱(IR1)
  • Sigma Aldrich:2136-89-2(sigmaaldrich)
  • 可燃性危险特性:明火可燃; 高热放出有毒氯化物和氮氧化物气体
  • 用途二:有机合成原料。用作染料中间体。医药工业用于制造克霉唑等。
  • 方法一:1.邻氯甲苯法以邻氯甲苯为原料，在三氯化磷存在下，通氯气制得。将邻氯甲苯加入反应锅中，再加3%的三氯化磷，于90℃沸腾情况下通入干燥的氯气，并用光照，通氯反应16h，吸氯增重为85-90%，反应升温达210-220℃，反应液相对密度达1.53（20℃）时为反应终点。经排氯、排盐酸气后，减压蒸馏，收集135-137℃（2kPa）馏分，得邻氯三氯甲苯。氯化反应也可以在氯化磷存在下进行。收率为74%。2.甲苯氯化法将甲苯和四氯化钛冷却到10℃左右开始通氯，反应温度控制在15-20℃。通氯至反应液相对密度达1.078-1.082为止，将反应液用水洗至pH为6-7，用无水氯化钙干燥后蒸馏收集156-160℃馏分，得含量约为77%的邻氯甲苯（含对氯甲苯）。再按上述方法，加五氯化磷通氯气氯化，也可制取该品。
  • 用途一:用于制备酸性媒介RH、酸性络合紫5RN及活性染料，也可用于制备原料药氯唑沙宗
  • Sigma Aldrich:95-85-2(sigmaaldrich)
  • 4-氯-2-氨基苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0284 2-氨基-4-氯苯酚 2-Amino-4-chlorophenol 25G 130元 2014/06/02 A0284 2-氨基-4-氯苯酚 2-Amino-4-chlorophenol 500G 928元 2010/06/21 109255000 4-氯-2-氨基苯酚 2-Amino-4-chlorophenol 97% 500 GR 1295元
  • 外观性质:淡棕色结晶。
  • MOL 文件:2136-89-2.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  6. C6 to C8 - Phenols
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Protected Alcohols/Phenols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers

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