2-Methylbenzene-1-Sulfonamide 邻甲苯磺胺

CAS 88-19-7 MFCD00007934

化学结构图

88-19-7
SMILES: Cc1ccccc1S(N)(=O)=O

化学属性

Mol. FormulaC7H9NO2S
Mol. Weight171.21
Melting Point156-158 °C
Flash Point178°(352°F)
TSCAYes
Boiling Point221 °C at 760 mmHg
Density1.271

别名和识别编码

Chemical Name2-Methylbenzene-1-Sulfonamide
CAS Number88-19-7
Synonym 2-Methylbenzenesulfonamide {LY} 2-Methylbenzenesulfonamide {} {LY} 2-Methylbenzenesulfonamide {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methylbenzenesulfonamide {} {} {} {} {} {}
MDL NumberMFCD00007934
PubChem Substance ID87576256
EC Number200-741-1
Beilstein Registry Number11(3)167
Alfabeta NameMETHYLBENZENESULFONAMIDE 21---
Reaxys-RN1102362
Chemical Name Translation邻甲苯磺胺
Wiswesser Line NotationZSWR B1
LabNetwork Molecule IDLN00159723
Canonical SMILESO=S(C1=CC=CC=C1C)(N)=O
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分类

  • Mutagenesis Research Chemicals
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • Impurities
  • Sulfur & Selenium Compounds
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonamides/Sulfinamides, Sulfur Compounds
  • {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards S - T, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards S - T
  • Aromatics
  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards S - T, 分析/色谱

产品应用

  • o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.

相关文献及参考

  • Short: III/20a
  • Short: EINECS
  • Short: III/5a
  • Beilstein:11(3)167
  • Stavric, B. et al.: J. Assoc. Offic. Anal. Chem., 57, 678 (1974); Ashby, J. et al.: Food Cosm. Toxicol., 16, 95 (1978); Eckhardt, K. et al.: Toxicol. Lett., 7, 51 (1980);

安全信息

WGK Germany2
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P405 Store locked up. 上锁保管。
  • P305+P351+P338+P337+P313
  • P308+P313
  • P337+P313
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H303 May be harmfully swallowed 吞食可能有害
RTECSXT4900000
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Hazard Codes Xn
Warnings IRRITANT
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13 gm/kg/96W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - leukemia
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 91,19,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4870 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1073,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 70 umol/plate
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
   Springer-Verlag, 1980  Volume(issue)/page/year: -,170,1980

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 56,163,1977

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
   Springer-Verlag, 1980  Volume(issue)/page/year: -,170,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4300 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   51,455,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 gm/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   PCBRD2 Progress in Clinical and Biological Research.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1975- Volume(issue)/page/year:
   109,339,1982

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 溶于乙醇和碱溶液,微溶于水和乙醚。

系列性分类


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