Thioacetamide 硫代乙酰胺

CAS 62-55-5 MFCD00008070

化学结构图

62-55-5
SMILES: CC(N)=S

化学属性

Mol. FormulaC2H5NS
Mol. Weight75.13
Melting Point112-114°C
Density1.37
SolubilitySoluble in water, ethanol
TSCAYes
Stability对湿度敏感
Appearance 无色或白色结晶。熔点113-114℃,25℃水中的溶解度16.3g/100ml,乙醇26.4g/100ml。极微溶于苯、乙醚。其水溶液在室温或50-60℃时相当稳定,但当有氢离子存在时,很快产生硫代氢而分解。新制品有时有硫醇臭、微吸潮。
Boiling Point111.7°C at 760 mmHg
Flash Point21.4°C

别名和识别编码

Chemical NameThioacetamide
Synonym Thioacetamide {LY} Thioacetamide {} {LY} Thioacetamide {} {} {LY} Thioacetamide {} {} {} {LY} Thioacetamide {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number62-55-5
PubChem Substance ID2723949
EC Number200-541-4
Beilstein Registry Number2,232
MDL NumberMFCD00008070
Reaxys-RN506006
Merck Number9319
Chemical Name Translation硫代乙酰胺
Wiswesser Line NotationZY1&US
LabNetwork Molecule IDLN00193918
InChIInChI=1S/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)
Canonical SMILESCC(N)=S
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分类

  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiocarbonyl Compounds
  • {SNA} Analytical Reagents for General Use, Gravimetric Reagents, Puriss p.a. ACS, T-Z, Puriss p.a. ACS, 分析/色谱, 分析试剂
  • {uni_hamburg} no charge; 1fragment
  • Analytical Reagents, Analytical Reagents for General Use,

产品应用

  • 用于分解氨基酸铜络合物。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。
  • 肝毒素和致癌剂,用于β-酮基酯的异构选择性还原。

相关文献及参考

  • Merck: 14,9319
  • Merck 14 ,9319
  • Short: II/25B
  • Merck: 14,9319 Beilstein:2,232
  • Short: II/27B

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H350 May cause cancer 可能致癌
  • H315 Causes skin irritation 会刺激皮肤
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T
RTECSAC8925000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P308+P313
  • P301+P312+P330
  • P308+P311
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Signal word
Safety Statements
Risk Statements
  • R45 May cause cancer 可能致癌
  • R52/53
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
UN Number
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen RT, stored under nitrogen Store at RT. {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored un
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg/12W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   28,1703,1968

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5140 mg/kg/47W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - prostate tumors
REFERENCE :
   JPBAA7 Journal of Pathology and Bacteriology.  (London, UK)  V.1-96,
   1892-1968.  For publisher information, see JPTLAS. Volume(issue)/page/year:
   72,415,1956

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1008 mg/kg/9W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 175,257,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 gm/kg/39W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   24,498,1970

{ha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 301 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,380,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 12,447,1904

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 500 ug/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   52,1167,1974

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Am

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1512 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 100 ug/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 19,642,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Primate - monkey Kidney
DOSE/DURATION           : 50 mg/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 57,193,1969

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CYTZAM Cytobiologie.  (Stuttgart, Fed. Rep. Ger.)  V.1-18, 1969-79.  For
   publisher information, see EJCBDN.  Volume(issue)/page/year: 11,392,1975

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   FHCYAI Folia Histochemica et Cytochemica.  (Cracow, Poland)  V.1-21,
   1963-83.  Volume(issue)/page/year: 8,11,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1935 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

其他信息

  • 上游原料:五硫化二磷 --> 乙酰胺
  • 用途四:用于分解氨基酸铜络合物。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。肝毒素和致癌剂,用于β-酮基酯的异构选择性还原。
  • Alfa Aesar:硫代乙酰胺,ACS,99% Thioacetamide, ACS, 99%(62-55-5)
  • Acros Organics:硫代乙酰胺 Thioacetamide, 99+%(62-55-5)
  • 用途三:用于生产催化剂、稳定剂、阻聚剂、电镀添加剂、照相药品、农药、染色助剂和选矿剂等。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。
  • Sigma Aldrich:62-55-5(sigmaaldrich)
  • 海关编码:29309070
  • 有轻微的硫醇臭。微吸湿。25℃时水中溶解度:16.3g/100ml,乙醇中溶解度:26.4g/100ml,微溶于乙醚。水溶液在或50~60℃时相当稳定,但当有氢离子存在时,很快分解产生硫化氢。最大吸收波长(水中)210、261、318nm(logε3.66、4.08、1.8)。有毒,最小致死量(大鼠,经口)200mg/kg。经试验表明,对实验动物有潜在致癌作用。有刺激性。
  • MOL 文件:62-55-5.mol
  • 有机试剂:硫代乙酰胺又称乙硫酰胺,是一种有机试剂,无色或白色片状结晶。溶于水、乙醇,极微溶于苯、乙醚,其水溶液在室温或50~60℃时相当稳定,放置2~3周不变,但当有氢离子存在时,很快产生硫化氢而分解,但水解作用随着溶液的酸度或碱度增加以及温度升高而加快。硫代乙酰胺在酸性和碱性溶液中的水解反应方程式为: 酸性溶液中:CH3CSNH2+2H2O----(NH4+)+CH3COO-+H2S 碱性溶液中:CH3CSNH2+2OH-----NH3+CH3COO-+HS- 由于在酸性或碱性溶液中水解生成H2S或HS-,故在分析化学中常被用来代替有毒和臭味的H2S,作为金属阳离子的组试剂或沉淀试剂。所得沉淀性质较好,易于分离。此外,亦可用作铋的测定试剂。制备方法:由乙酰胺与硫化铝加热、乙腈与硫化氢反应,或乙酰胺与K3PS4反应制取。
  • 硫代乙酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30177714 硫代乙酰胺;乙硫酰胺 25g 35元 2011/04/16 T0187 硫代乙酰胺 Thioacetamide 25G 218元 2011/04/16 T0187 硫代乙酰胺 Thioacetamide 500G 1930元
  • 方法一:乙腈与硫化氢反应,或使乙酰胺与五硫化二磷反应可制得硫代乙酰胺。
  • F:10
  • 图谱信息:硫代乙酰胺(62-55-5)红外图谱(IR1) 硫代乙酰胺(62-55-5)红外图谱(IR2) 硫代乙酰胺(62-55-5)质谱(MS)
  • MSDS 信息:Ethanethioamide(62-55-5).msds
  • 下游产品:2-(2,5-二甲基-1,3-噻唑-4-基)乙酸 --> 2,5-二甲基噻唑-4-乙酸甲酯 --> 2,4-二甲基-1,3-噻唑-5-羧酸 --> (2S,5R,6R)-6-[(2R)-2-[(2R)-2-氨基-3-(N-甲基氨基甲酰)-丙酰胺基]-2-(4-羟基苯基)乙酰胺基]-3,3-二甲基-7-氧代-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸三水物 --> 2-甲基-1,3-噻唑-4-羧酸 --> 2-甲基噻唑-4-甲酸乙酯
  • 用途二:用作聚合物的硫化剂及交联剂、橡胶助剂、医药原料等
  • 用途一:用作分析试剂
  • TCI Shanghai:硫代乙酰胺 Thioacetamide,>;98.0%(GC)(T)(62-55-5)

系列性分类


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