Tetramethylurea, 99% 1,1,3,3-四甲基脲

CAS 632-22-4 MFCD00008319

化学结构图

632-22-4
SMILES: CN(C)C(=O)N(C)C

化学属性

Mol. FormulaC5H12N2O
Mol. Weight116.16
Density0.968
Refractive index1.4490 to 1.4530
Boiling Point62-63°C at 12 mmHg
Melting Point-1.2 °C
Flash Point75°C(lit.)
SolubilityMiscible with water
TSCAYes
Appearance 无色液体,密度 0.9879 ,熔点 -1°C ,沸点 174-178°C ,折射率 1.4496-1.4516 ,闪点 65°C ,水溶性 miscible

别名和识别编码

Chemical NameTetramethylurea, 99%
Synonym 1,1,3,3-Tetramethylurea {LY} 1,1,3,3-Tetramethylurea {} {LY} 1,1,3,3-Tetramethylurea {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,1,3,3-Tetramethylurea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number632-22-4
Beilstein Registry Number773898
EC Number211-173-9
MDL NumberMFCD00008319
PubChem Substance ID12437
Reaxys-RN773898
Merck Number9230
Chemical Name Translation1,1,3,3-四甲基脲
Wiswesser Line Notation1N1&VN1&1
LabNetwork Molecule IDLN00198582
InChIInChI=1S/C5H12N2O/c1-6(2)5(8)7(3)4/h1-4H3
Canonical SMILESO=C(N(C)C)N(C)C
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分类

  • {uni_hamburg} no charge; urea; 1fragment
  • Bioactive Small Molecules, Building Blocks, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Organic Building Blocks, T, Ureas
  • {SNA} Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks, Ureas
  • {SNA} Bioactive Small Molecules, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks, T, Ureas, 细胞生物学

相关文献及参考

  • Merck: 14,9230 Beilstein:4,74
  • Short: II/25D
  • Merck: 14,9230
  • Reacts with oxalyl chloride to give tetramethyl chloroformamidinium chloride, a useful reagent for the conversion of carboxylic acids and dialkyl phosphates to anhydrides and pyrophosphates respectively: Bull. Chem. Soc. Jpn., 56, 3529 (1983).
  • High-boiling dipolar aprotic solvent. The polar nature, wide liquid range and high solvent power of tetraalkylureas make them suitable solvents for a wide range of reactions; review: Angew. Chem. Int. Ed., 18, 503 (1979).

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T Xn
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H302 Harmful if swallowed 吞食有害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSYU2625000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P330 Rinse mouth. 漱口
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ACIEAY Angewandte Chemie, International Edition in English.  (VCH Pub.,
   Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441)  V.1-    1962-
   Volume(issue)/page/year: 3,260,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 54,188,1935

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 19,1073,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 1600,333,1966

TYPE

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 79,1171,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 999 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 30,585,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rod

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   41,35,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 250 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/ye

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • 用途一:用于合成农药,合成染料,碱金属。
  • Acros Organics:1,1,3,3-四甲基脲 1,1,3,3-Tetramethylurea, 99%(632-22-4)
  • Sigma Aldrich:632-22-4(sigmaaldrich)
  • 毒性分级:中毒
  • 急性毒性:口服- 小鼠 LD50: 2920 毫克/ 公斤
  • 海关编码:29241900
  • 下游产品:四甲基氟代脲六氟磷酸酯
  • TCI Shanghai:四甲基脲 Tetramethylurea,>;98.0%(GC)(632-22-4)
  • MSDS 信息:1,1,3,3-Tetramethylurea(632-22-4).msds
  • 类别:易燃液体
  • 储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂分开存放
  • F:3-10
  • 1,1,3,3-四甲基脲价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T0158 四甲基脲 Tetramethylurea 25G 182元 2014/06/02 T0158 四甲基脲 Tetramethylurea 500G 1460元 2010/06/21 138491000 1,1,3,3-四甲基脲 1,1,3,3-Tetramethylurea 99% 100 ML 661元
  • 图谱信息:1,1,3,3-四甲基脲(632-22-4)核磁图( 13 CNMR) 1,1,3,3-四甲基脲(632-22-4)红外图谱(IR1) 1,1,3,3-四甲基脲(632-22-4)Raman光谱 1,1,3,3-四甲基脲(632-22-4)质谱(MS) 1,1,3,3-四甲基脲(632-22-4)核磁图( 1 HNMR)
  • Alfa Aesar:四甲基尿素,99% Tetramethylurea, 99%(632-22-4)
  • 和水混溶,和所有的常规有机溶剂混溶,包括石油醚。
  • 可燃性危险特性:遇明火、高温、强氧化剂可燃; 燃烧排放有毒氮氧化物烟雾
  • MOL 文件:632-22-4.mol
  • 灭火剂:泡沫、二氧化碳、干粉、1211、砂土

系列性分类