Tetramethylthiouram Disulfide 福美双/二硫化四甲基秋兰姆

CAS 137-26-8 MFCD00008325

化学结构图

137-26-8
SMILES: CN(C)C(=S)SSC(=S)N(C)C

化学属性

Mol. FormulaC₆H₁₂N₂S₄
Mol. Weight240.43
Melting Point150-152 °C
Density1.43
Flash Point89°(192°F)
TSCAYes
Boiling Point
Autoignition Point316 °F
Solubility16.5 MG/L (20 ºC)

别名和识别编码

Chemical NameTetramethylthiouram Disulfide
CAS Number137-26-8
Synonym Accel TMT Arasan 42-S Arasan 50 red BIS(DIMETHYLTHIOCARBAMOYL) DISULFIDE Bis(dimethylthiocarbamoyl) Disulfide Cun Falitiram Fernacol Fernasan A Fl Hermat TMT Mercuram Methyl Tuads Metiur N,N,N',N'-Tetramethy N,N-Tetramethylthiuram disulphide Nobecutan Nocceler TT PURALIN(R) TERSAN(R) TETRAMETHYLTHIURAM D TMTD Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl- Thiram {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID125308534
EC Number205-286-2
Beilstein Registry Number4,76
MDL NumberMFCD00008325
Merck Number9371
Chemical Name Translation福美双/二硫化四甲基秋兰姆
Reaxys-RN1725821
Wiswesser Line Notation1N1&YUS&SSYUS&N1&1
LabNetwork Molecule IDLN00192941
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分类

  • {SNA} 2000/60/EC, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Dithiocarbamates, Environmental Standards, European Community: ISO, DIN and DL 152, Fungicides, Method and Regulation Specific, Other, Others, Pesticides, Pesticides & Metabolites, Pesticides, Bactericides, Fungicides and Disinfectants, Q-Z, Standards for Personal Care and Cosmetic Products, T,
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiocarbonyl Compounds
  • {SNA} 2000/60/EC, All alpha

产品应用

  • 硫化促进力非常强，但无氧化锌存在时，则完全不硫化。

相关文献及参考

  • Short: II/27B
  • Short: III/5a
  • Merck: 14,9371 Beilstein: 4,IV,242
  • Sahni, M.L. et al.: Ind. Phytopathol., 20, 71 (1967); Vir, D.: Pesticide, 11, 39 (1977); Welch, J.F. et al.: Plant. Dis. Rep., 35, 57 (1952);
  • Merck: 14,9371

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H302+H332
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes
RTECSJO1400000
Precautionary statements
  • P308+P311
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P302+P352+P333+P313+P362+P364
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P308+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P350
  • P337+P313
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
Signal word
Safety Statements
UN Number UN3077 2771/2811 3077
Risk Statements
  • R48/22
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R50/53
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Packing GroupIII
Hazard Class9
Storage condition +4 0-6°C 4
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 46 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-159

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15300 mg/kg/51W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   34,283,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 108 mg/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   RPZHAW Roczniki Panstwowego Zakladu Higieny.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - conditioned vitamin deficiency
   Skin and Appendages - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   34,283,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 6(7),28,1962

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 30 ug/m3/5Y-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Cardiac - other changes
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
REFERENCE :
   VRDEA5 Vrachebnoe Delo.  Medical Practice.  (V/O Mezhdunarodnaya Kniga,
   113095 Moscow, USSR) No.1-    1918-  Vo

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1109 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 15,507,1990

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Si

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4 gm/L
REFERENCE :
   SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu
   1, SF-00290 Helsinki, 29, Finland)  V.1-    1975- Volume(issue)/page/year:
   9(Suppl 2),27,1983

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   45,101,1980

TYPE OF TES

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1000 ppm
REFERENCE :
   MMAPAP Mycopathologia et Mycologia Applicata.  (The Hague, Netherlands)
   V.5-54(4), 1950-74.  For publisher information, see MYCPAH.
   Volume(issue)/page/year: 5

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 ug/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   45,101,1980

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 150 mg/kg/8W (Continuous)
REFERENCE :
   FCTOD7

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5 mg/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   23,373,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   35,83,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For Engli

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1190 mg/kg
SEX/DURATION            : female 16-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   35,83,1976

其他信息

  • 方法二:由二甲胺、二硫化碳、氨水进行缩合反应得二甲基二硫代氨基甲酸铵，再经双氧水氧化为成品。
  • 用途一:用作天然胶、合成胶及胶乳的超促进剂
  • 毒性分级:中毒
  • 用途二:用于制造电缆、电线、轮胎等橡胶制品
  • 溶于醇、苯、氯仿和二硫化碳，不溶于水、稀碱和汽油。有特臭、无味。
  • 职业标准:TWA 5 毫克/立方米; STEL 10 毫克/立方米
  • 刺激数据:眼睛-兔子 100 毫克/24小时 中度
  • 促进剂 T价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80125580 二硫化四甲基秋兰姆;二硫化双(硫羰基二甲胺);促进剂T;二硫化双二甲胺甲硫羰基;N,N′-四甲基二硫双硫羰胺 250g 764元 2010/06/21 138
  • Acros Organics:福美双/二硫化四甲基秋兰姆 Tetramethylthiuram disulfide, 97%(137-26-8)
  • 海关编码:29303000
  • 方法一:福美钠的制备 二甲胺盐酸盐和二硫化碳在氢氧化钠存在下生成二甲氨基二硫代甲酸钠（福美钠），反应温度50～55℃，pH值为8～9。 福美双的制备 福美钠（或福美铵）与双氧水在硫酸存在下生成福美双，温度控制在10℃以下，终点pH值3～4。也可用氯气代替双氧水和硫酸，反应在筛板塔中进行，氯气经稀释从塔底部进入，塔顶喷淋5%福美钠溶液，称氯气-空气氧化法。也可采用亚硝酸钠氧化法或电解氧化法。
  • 类别:有毒物品
  • 中毒症状:恶心、呕吐、腹痛、腹泻，重者头痛、头晕，心律、呼吸加快，血压下降，抽搐、循环衰竭，呼吸麻痹而死。
  • 上游原料:氢氧化钠 --> 亚硝酸钠 --> 氢氧化铵 --> 过氧化氢 --> 氯 --> 二硫化碳 --> 二甲胺 --> 二甲基二硫 --> 二甲基二硫代氨基甲酸钠 --> 二硫代氨基甲酸铵 --> 筛板塔 --> 甲基二硫代氨基甲酸
  • MSDS 信息:四甲基二硫代秋兰姆(137-26-8).msds
  • 图谱信息:促进剂 T(137-26-8)红外图谱(IR1) 促进剂 T(137-26-8)红外图
  • 下游产品:氯丁橡胶 --> 种衣剂 --> 一硫化四甲基秋兰姆 --> 二甲氨基硫代甲酰氯 --> 甲基硫菌灵可湿性粉剂 --> 福·甲硫可湿性粉剂 --> 福美双+腈菌唑 --> 双二甲基二硫代氨基甲酸甲胂
  • MOL 文件:137-26-8.mol
  • 促进剂 T价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80125580 二硫化四甲基秋兰姆;二硫化双(硫羰基二甲胺);促进剂T;二硫化双二甲胺甲硫羰基;N,N′-四甲基二硫双硫羰胺 250g 764元 2010/06/21 138485000 促进剂 T Tetramethylthiuram disulfide 97% 500 GR 294元 2010
  • 毒性:大鼠急性经口LD 50 为780～865
  • Sigma Aldrich:137-26-8(sigmaaldrich)
  • 外观性质:白色或灰白色、有特殊气味、结晶粉末。
  • Alfa Aesar:二硫化四甲基秋兰姆,97% Tetramethylthiuram disulfide, 9
  • 用途三:用作天然胶、顺丁胶、丁苯胶、异戊胶的后效性促进剂
  • 急性毒性:口服-大鼠 LD50: 560 毫克/公斤; 口服-小鼠 LD50: 1250 毫克/公斤
  • 灭火剂:砂土、干粉、泡沫
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 用途六:该品作为农药通常称为福美双，主要用于处理种子和土壤，防治禾谷类白粉病、黑穗病及蔬菜病害。该品作为天然胶、合成胶及胶乳的超促进剂，通常称促进剂TMTD，是秋兰姆硫化促进剂的代表，占同类产品总量的85%。作为

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiocarbonyl Compounds - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiol Esters - Sulfur Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Alpha sort - Pesticides & Metabolites
  7. Q-Z - Alpha sort
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TA - TE - T
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfoxides
  1. Materials Science 材料科学
  2. Photopolymerization Initiators
  1. Functional Group 官能团索引
  2. disulfide
  1. Functional Group 官能团索引
  2. thiocarbamic acid

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